Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary

Kurt, Ali; İsaoğlu, Ünal; Yılmaz, Mehmet Emin; Çalık, Muhammet; Polat, Beyzagül; Hakan, Hamit; İngeç, Metin; Süleyman, Halis

doi:10.1016/j.jpedsurg.2011.04.092

Cited by 20 publications

(15 citation statements)

References 30 publications

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“…In addition, H 2 receptor antagonists have also been shown to be hydroxyl radical inhibitors produced in the Fe 2+ -H 2 O 2 reaction (van Zyl et al, 1993). It has been shown that H2 receptor antagonists alter the oxidant/antioxidant balance in favour of antioxidants in ovarian tissue (Kurt et al, 2011). In our study, tGSH, GPO and SOD levels in ovarian and heart tissues were preserved at normal levels in the nizatidine group and were not significantly changed.…”

Section: Resultssupporting

confidence: 45%

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The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

Delibaş

Karaca

Yapça

et al. 2018

IJAR

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An ischaemia/reperfusion (I/R) injury in an organ can also cause damage to other organs. In this study, the effects of nizatidine were investigated on ovarian I/R injury and subsequent heart damage in rats. Rats were divided into groups; ovarian I/R (IRG), nizatidine 25 mg/kg+ ovarian I/R (NIR), and control (CG) groups. The NIR and IRG groups were given 2 hours of ischaemia followed by 2 hours of reperfusion by applying, and subsequently releasing, a vascular clip to the right ovarian artery. While oxidant levels in the IRG group were higher than NIR and CG groups, antioxidant levels were lower. Necrosis, congested blood vessels, haemorrhage, leukocyte infiltration and oedema were observed in the ovarian and heart tissues of the IRG group. These findings were reduced in the NIR group. Nizatidine suppressed oxidative stress in ovarian and heart tissues and may be useful in prevention of I/R-induced ovarian and cardiac injury.

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Section: Resultssupporting

confidence: 45%

“…This was followed by two hours of reperfusion in which the vascular clip was released. (Kurt et al, 2011). At the end of this period, all animals were killed by a high dose of anaesthesia.…”

Section: Materials and Methods Animalsmentioning

confidence: 99%

The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

Delibaş

Karaca

Yapça

et al. 2018

IJAR

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“…Kurt et al [26] histopathologically showed that damage occurs in the ovary tissue of rats when oxidant levels are high. Isaoglu et al [27] reported a significant increase in the levels of oxidants-compared with the levels in the healthy group-in ovary tissue in which only ischemia occurred.…”

mentioning

confidence: 99%

Tissue Damage and Oxidant/Antioxidant Balance

Kısaoğlu

Borekci

Yapça

et al. 2013

EAJM

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The oxidant/antioxidant balance in healthy tissues is maintained with a predominance of antioxidants. Various factors that can lead to tissue damage disrupt the oxidant/antioxidant balance in favor of oxidants. In this study, disruptions of the oxidant/antioxidant balance in favor of oxidants were found to be a consequence of the over-consumption of antioxidants. For this reason, antioxidants are considered to be of importance in the prevention and treatment of various types of tissue damage that are aggravated by stress. Key Words: Antioxidant, Ischemia, Oxidant ÖzetSağlıklı dokularda oksidan/antioksidan denge antioksidanların üs-tünlüğüyle sürdürülür. Doku hasarına yol açabilecek çeşitli agresif faktörler oksidan/antioksidan dengenin oksidanların leyhine bozulmasını sağlar. Bu derleme çalışmasında, oksidan/antioksidan dengenin oksidanlar leyhine bozulmasının, antioksidan sistemlerin aşırı harcanmasına bağlı olarak geliştiği rapor edilmiştir. Bu nedenle oksidatif strese bağlı çeşitli doku hasarının önlenmesinde ve tedavisinde antioksidanların önemli olduğu anlaşılmaktadır.

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“…14 FMT has antioxidant activity since it was shown to act as an acceptor of ROS. 15,16 From these previous observations, RF-sensitized photooxidation may be partly involved in the photodegradation pathways of FMT/RF. However, the detailed mechanisms of the photodegradation of FMT/RF have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 81%

Photochemical Mechanism of Riboflavin-Induced Degradation of Famotidine and a Suggested Pharmaceutical Strategy for Improving Photostability

Uchida

Onoue

Ohtake

et al. 2016

Journal of Pharmaceutical Sciences

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The present study aimed to clarify the mechanism of photodegradation of famotidine with riboflavin (FMT/RF), and to develop a photochemically stabilized formulation of FMT/RF. Photochemical properties of RF were characterized by UV-VIS spectral analysis, reactive oxygen species (ROS) assay, and photostability testing. Pharmacokinetic study was conducted in rats after intravenous administration of FMT (1 mg/kg) formulation containing RF (0.01 mg/kg). The UV-VIS spectral pattern of RF partly overlapped with the sunlight spectrum, and ROS generation from photoirradiated RF was remarkable; thus, RF had high photoreactive potential. In the photostability testing, after irradiation (250 W/m(2)), degradation rate for FMT in FMT/RF was ca. 11-fold higher than that in FMT alone. The addition of radical scavengers to FMT/RF led to attenuated photodegradation of FMT/RF; in particular, the addition of L-ascorbic acid (vitamin C; VC) to FMT/RF showed ca. 86% inhibition of the photodegradation of FMT/RF. The pharmacokinetic study on FMT indicated that the addition of VC (1 mg/kg) to FMT/RF had no significant impact on the pharmacokinetic behavior of FMT. These findings suggest that ROS-mediated photochemical reaction would be involved in the photodegradation pathway of FMT/RF, and the complementary use of VC might be an attractive approach to improve the photostability of FMT/RF.

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Biochemical and histological investigation of famotidine effect on postischemic reperfusion injury in the rat ovary

Cited by 20 publications

References 30 publications

The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats

Tissue Damage and Oxidant/Antioxidant Balance

Photochemical Mechanism of Riboflavin-Induced Degradation of Famotidine and a Suggested Pharmaceutical Strategy for Improving Photostability

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