Biochemical and histopathological effects of green tea nanoparticles in ironized mouse model

Abstract

Transfusion in the treatment of thalassemia gives rise to iron deposits in many organs. Since there are many obstacles in the use of deferoxamin (DFO) as an iron chelating agent, it is important to find another alternative therapy that can act as iron chelation. The study aims to compare the histopathological pictures of the heart and spleen in iron-induced rats after administration of DFO and nanoparticles of green tea extract. The research used experimental research design with a post-test only control group. Experimental nano green teas were divided into four treatment groups; no diet, DFO supplementation, nano green tea supplementation, and a combination of both DFO and green tea. Ferritin and glutathione peroxides were used as biochemical parameters, and histopathological pictures of the heart and spleen were recorded. The study showed that there was significant improvement in the rats receiving DFO and nanoparticles of green tea compared with the rats in the no diet group. The study also reported that nano green tea has an effect comparable to DFO.

Chemical profile and in vivo toxicity evaluation of unripe Citrus aurantifolia essential oil

“…The decreased levels of hemoglobin might have resulted from the inability to utilize iron to make hemoglobin, as a result there was a decreased level of MCV due to small average RBCs size which might be a deficiency of iron, and this phenomenon is supported by mild to moderate hemosiderin deposit within the spleen of these groups. This has been reported in previous studies [48].…”

“…5B) and sub-chronic (Fig. 5E) stages of the study suggests the destruction of defective or damaged red blood cells, as previously reported by other studies [47,48]. This could also be attributed to the cytotoxic effect of the major constituent of the LEO germacrene D [37].…”

Phytofabrication of Iron Nanoparticles for Hexavalent Chromium Remediation

“…Optimal nanoparticle properties for pollution remediation include particles that are small, monodisperse, possess no particle–particle attraction, and do not passivate readily under aerobic and aqueous conditions . Our findings, along with other studies that utilize antioxidant rich green tea extracts to generate iron nanoparticles, have shown that high antioxidant concentrations lead to particles that agglomerate and form chainlike structures, − thereby reducing the nanoparticle surface area available for remediative interactions.…”

Potential of Jamu in Nanotechnology Perspective as an Alternative Treatment for Covid-19

“…Sulistyo and colleagues (2017) observed that green tea nanoparticles have better effects in ironized mouse model thalassemia as compared to the green tea as a free compound. The green tea extract prepared into nanoparticles using chitosan as a carrier crosslinked with sodium tripolyphosphate (Sulistyo et al, 2017).…”