Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries

Yıldırım, Ali Erdem; Dalgıç, Ali; Divanlıoğlu, Denizhan; Akdağ, Rıfat; Çetinalp, Nuri Eralp; Alagöz, Fatíh; Helvacıoğlu, Fatma; Take, Gülnur; Güvenç, Yahya; Koksal, Ismet; Belen, Ahmet Deniz

doi:10.5137/1019-5149.jtn.12852-14.2

Cited by 11 publications

(20 citation statements)

References 34 publications

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“…According to the results, the molecular mechanism underlying the therapeutic impact of Cin on sciatic nerve damage may include the control of inflammatory and oxidant factors [Chao et al, 2008;Ho et al, 2013;Roghani et al, 2017]. Antioxidants such as Cin are promising to counteract the tissue-injuring influence of the inflammatory response [Yildirim et al, 2015]. This study also showed that Cin 30 is optimal therapeutically, and the other doses (Cin 10 and 90) could not have sufficient clinical impacts on sciatic nerve repair.…”

Section: Discussionmentioning

confidence: 80%

“…After a crush injury, endoneurial edema in the peripheral nerve affects the microenvironment by raising the pressure, lowering the blood flow, or altering the electrolyte concentration in the endoneurium. In the case of delayed restoration of adequate blood flow, ischemia causes wallerian axonal degeneration [Yildirim et al, 2015;Alvites et al, 2018], which takes place at the point of damage to the distal end of the nerve. It describes the axon demolition and its surrounding myelin, and limited degeneration exists just proximal to the injury [Atik et al, 2011].…”

Section: Discussionmentioning

confidence: 99%

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Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Jahromi

Mohammadghasemi²,

Kasmaie

et al. 2020

Cells Tissues Organs

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Peripheral nerve injury is a common clinical issue induced by trauma, tumor, and damage caused by treatment. Such factors create chemical and inflammatory alterations at the injury site, which increase nerve deterioration. Thus, minimizing these modifications can lead to nerve protection after injury. The present study sought to evaluate the possible improvement in nerve regeneration and enhancement of functional outcomes by cinnamaldehyde (Cin) administration following sciatic nerve crush in a rat model. Rats (n = 48) were distributed into 6 groups, including sham, injury, DMSO (vehicle group), and Cin groups (10, 30, and 90 mg/kg/day). Using small hemostatic forceps, crush injury was induced in the left sciatic nerve. Thereafter, Cin was administered for 28 successive days. Weekly records were taken for sciatic functional index (SFI) measurements. Further assessments including electrophysiological and histomorphometric evaluations, gastrocnemius muscle wet weight measurements, and estimation of the serum total oxidant status were performed. According to the results, Cin could accelerate sciatic nerve recovery after crush injury, and the dose of 30 mg/kg/day of Cin had better impacts on SFI recovery, muscle mass ratio, and myelin content. The current research demonstrated that Cin positively affects peripheral nerve restoration. Therefore, Cin therapy could be considered as a potential treatment method for peripheral nerve regeneration and its functional recovery. However, more investigations are required to further validate the study results and evaluate the optimal dose of Cin.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Jahromi

Mohammadghasemi²,

Kasmaie

et al. 2020

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Four weeks later, all rats were deeply anesthesized (Ketamine hydrochloride 150 mg/kg) and specimens of the damaged sciatic nerves, including 0.5 cm proximal and distal nerve segments, were collected from the prior incision sites. At the end of the study, the rats were sacrificed (40).…”

Section: Anesthesia and Surgical Proceduresmentioning

confidence: 99%

Effect of creatine on rat sciatic nerve injury: a comparative ultrastructural study

Helvacıoğlu

Kandemir²,

Karabacak³

et al. 2016

Turkish Neurosurgery

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“…Abnormal signals come not only from damaged axon but also from intact nociceptors that share the innervation of damaged nerves [3]. Peripheral nerve damage is common and important cause of long-term morbidity [4]. Upon exposure to nerve compression, the range of functional loss may oc-X.Z.…”

Section: Introductionmentioning

confidence: 99%

Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats

Xiao

Chu

et al. 2019

Pharmacology

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To explore the analgesic effect of dizocine combined with ropivacaine on recurrent neuropathic pain in rat model of peripheral nerve compression. Rats were randomly divided into 5 groups: sham control group (S), peripheral nerve compression model group (M), dizocine group (D), ropivacaine group (R), and combined drug group (DR). Rat peripheral nerve compression model was constructed to observe the symptoms of the rats before and after surgery. Mechanical withdrawal threshold was measured on the 21st day after surgery. The electrophysiological changes of rat peripheral nerve were measured by biopotential recording system, including proximal latency, distal latency, and compound muscle action potential. The incubation period and nerve conduction velocity were further obtained. Histological changes were observed by HE staining and toluidine blue staining. Axon number and myelin damage grade were performed, and the ultrastructure was observed by transmission electron microscopy (TEM). The mechanical withdrawal threshold, nerve conduction velocity, and compound muscle action potential were effectively increased in combination group. However, the proximal latency, distal latency, and incubation period were significantly reduced. Furthermore, dizocine combined with ropivacaine can effectively reduce the degree of myelination. TEM shown that the DR group had the best therapeutic effect, and the histological appearance of the cross section was quite similar to that of the S group. Dizocine combined with ropivacaine has a significant analgesic effect in rat model of peripheral nerve compression.

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Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries

Abstract: This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury.

Cited by 11 publications

References 34 publications

Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Cinnamaldehyde Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Effect of creatine on rat sciatic nerve injury: a comparative ultrastructural study

Analgesic Effect of Dizocine Combined with Ropivacaine on Recurrent Neuropathic Pain in Peripheral Nerve Compression Rats

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