Biochemical and Molecular Studies on the Role of Rosemary (Rosmarinus officinalis) Extract in Reducing Liver and Kidney Toxicity Due to Etoposide in Male Rats

Almakhatreh, Majd; Hafez, Ezar; Tousson, Ehab; Masoud, Ahmed

doi:10.9734/ajrimps/2019/v7i430126

Cited by 13 publications

(9 citation statements)

References 29 publications

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“…In our experiments, we found that the ALT, AST, and LDH were significantly lower in Group 3 compared with Group 2. This results is in agreement with the findings of Karataş et al [25], and Almakhatreh et al [26]. R. Officinalis extract greatly lowered the blood-brain barrier permeability disruption and injuries, moreover, it lessens the effect of the myocardial infarction and neurological deficit scores after focal Ischemia-Reperfusion.…”

Section: Resultssupporting

confidence: 93%

The Beneficial influence of Rosemary Aqueous Extract on the treatment of oxidative stress-induced myocardial Ischemia in Rats. Z. H. AL-Qaisi1, S. M. Abbood1, M. T. Mohammed 1, S. M. Kadhim2 1Department of Chemistry, College of Science, Mustansiriya University, Iraq 2Ministry of Education, Rusafa-1, Iraq Corresponding author: dr.mustafa@uomustansiriyah.edu.iq

et al. 2021

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Ischemia "stroke" may occur in various combinations of clinical illnesses. The effects of such an Ischemic represent a serious problem. Oxidative stress has been shown to act as one of the main causes of Myocardial Ischemia-Reperfusion Injury (IR). Reperfusion injury is defined as the action of returning the flow of blood to an organ or tissue after a period of stroke or myocardial infarction (MI). R. Officinalis (Rosemary) has a diverse therapeutic against many illnesses. Further, recent evidence also gives R. Officinalis a major role in protecting diverse organs from harmful oxidative stress. So, R.Officinalis seems like a good protect to the myocardial against the IR Injury. The study included the components of essential oils of the rosemary leaves in the watery extract and determine whether rosemary protects form Ischemia-Reperfusion induced myocardial ischemia. We divided forty-five Wister rats into three groups Group 1 as the control group, Group 2 underwent surgery without extract therapy, and Group 3 with extract therapy. Wister rats in Group 2, and Group 3 underwent myocardial ischemia for 45 min followed by 90 min period of Reperfusion. Animals in group 3 received rosemary (1 mL/g) for 14 days also, before Ischemia, and before Reperfusion. We found that the extract comprises from many essential oils. The levels of cardiac markers (AST, ALT, and LDH) and Oxidative stress markers (NO, and LPO) in group 3 a significantly decreased compared to group 2. Based on the results, the R.Officinalis treatment lessens the effect of Ischemia-Reperfusion on the rat's heart, including the induce myocardial infarction.

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Section: Resultssupporting

confidence: 93%

The Beneficial influence of Rosemary Aqueous Extract on the treatment of oxidative stress-induced myocardial Ischemia in Rats. Z. H. AL-Qaisi1, S. M. Abbood1, M. T. Mohammed 1, S. M. Kadhim2 1Department of Chemistry, College of Science, Mustansiriya University, Iraq 2Ministry of Education, Rusafa-1, Iraq Corresponding author: dr.mustafa@uomustansiriyah.edu.iq

et al. 2021

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“…According to numerous studies, plant ingredients and their extracts were used in anticancer, anti‐inflammation, reducing renal and hepatotoxicity, and treat many diseases . Vitamin B17 (VB17), amygdalin and formerly called laetrile is one of many nitrilosides which are natural cyanide containing substances, which is abundant in the seeds of Prunasins family, such as apricots, apples, almonds, peaches, and other rosaceous plants .…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14][15][16] According to numerous studies, plant ingredients and their extracts were used in anticancer, anti-inflammation, reducing renal and hepatotoxicity, and treat many diseases. [17][18][19][20][21] Vitamin B17 (VB17), amygdalin and formerly called laetrile is one of many nitrilosides which are natural cyanide containing substances, which is abundant in the seeds of Prunasins family, such as apricots, apples, almonds, peaches, and other rosaceous plants. 22,23 VB17 consists of two molecules of glucose, one of them is benzaldehyde which induces an analgesic action, the second is hydrocyanic acid which is an antineoplastic compound and used to treat the tumor and relieve pain.…”

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confidence: 99%

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Mutar

Tousson

Hafez

et al. 2019

Environmental Toxicology

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Cancer is the major cause of death and many factors that lead to its occurrences, such as environmental pollution and pesticides and other factors. Ehrlich carcinoma development depends on many things associated with the environment, nutrition, personal habits, and family history. The present study aimed to evaluate the potential protective effects of vitamin B17 (VB17) against Ehrlich ascites carcinoma (EAC) that induced kidney toxicity in female mice. The mice were divided into five groups (first group, control group; second group, VB17 group; third group, EAC group; fourth group, pretreated EAC with VB17; fifth group, cotreated EAC with VB17). Results showed the VB17 in pretreated (G4) and cotreated (G5) groups lead to an improvement in DNA damage and cytological examination, in addition significantly (P < .05) increase in Na+, red blood cell, hemoglobin, hematocrit value, mean corpuscular hemoglobin (MCH), and MCH concentration, whereas significantly (P < .05) decrease in urea, creatinine, K+, platelets, and white blood cells while insignificant (P < .05) changes in mean corpuscular volume when compared to the EAC group. Many histopathological changes were observed in kidney sections in EAC as marked damage and degenerated, glomerular atrophy, the Malpighian corpuscles that lost their characteristic configuration. On the other hand, a moderate improvement and arrangement in the kidney histological structure in pretreated VB17 + EAC, while a mild enhancement and arrangement of the kidney structure in cotreated EAC + VB17. In addition, depletion in renal P53 and PCNA protein expression compared with the EAC group. It could be concluded that VB17 has a potential renal protective effect against EAC cells induced kidney injury.

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“…Chemotherapeutic treatment of rhabdomyosarcoma includes the use of agents such as doxorubicin, vinblastine, and etoposide. Combination of these drugs with rosemary extracts allowed to diminish the concentration of the chemical agent, thus reducing its toxic effects [ 45 , 54 ]. Regarding the cytotoxic activity of R. officinalis on rhabdomyosarcoma cell lines, there is lack of literature data.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

et al. 2022

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Rosmarinus officinalis is a well-studied plant, known for its therapeutic properties. However, its biological activity against several diseases is not known in detail. The aim of this study is to present new data regarding the cytotoxic activity of a hydroethanolic extract of Rosmarinus officinalis on glioblastoma (A172) and rhabdomyosarcoma (TE671) cancer cell lines. The chemical composition of the extract is evaluated using liquid chromatography combined with time-of-flight mass spectrometry, alongside its total phenolic content and antioxidant activity. The extract showed a promising time- and dose-dependent cytotoxic activity against both cell lines. The lowest IC50 values for both cell lines were calculated at 72 h after treatment and correspond to 0.249 ± 1.09 mg/mL for TE671 cell line and 0.577 ± 0.98 mg/mL for A172 cell line. The extract presented high phenolic content, equal to 35.65 ± 0.03 mg GAE/g of dry material as well as a strong antioxidant activity. The IC50 values for the antioxidant assays were estimated at 12.8 ± 2.7 μg/mL (DPPH assay) and 6.98 ± 1.9 μg/mL (ABTS assay). The compound detected in abundance was carnosol, a phenolic diterpene, followed by the polyphenol rosmarinic acid, while the presence of phenolic compounds such as rhamnetin glucoside, hesperidin, cirsimaritin was notable. These preliminary results suggest that R. officinalis is a potential, alternative source of bioactive compounds to further examine for abilities against glioblastoma and rhabdomyosarcoma.

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Biochemical and Molecular Studies on the Role of Rosemary (Rosmarinus officinalis) Extract in Reducing Liver and Kidney Toxicity Due to Etoposide in Male Rats

Cited by 13 publications

References 29 publications

Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

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