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We described herein the synthesis of bis-1,3,4-oxadiazole containing glycine moiety. N-{5-[5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-yl-sulfanyl]-1,3,4-oxadiazole-2-yl-methyl}-4-methoxybenzamide was fully characterized by elemental analysis, FT-IR and 1 H NMR spectroscopy. Also this study was designed to show the effects of bis-oxadiazole compound on the activities of some transferase enzymes such as: GOT, GPT and c-GT in sera. This compound demonstrated activation on GOT and GPT activities, inhibitory effects on the c-GT activity. These effects increased with increasing the concentration of the compound. The causes of the increases and decreases in the enzymes activities are discussed.

This study was designed to show the effects of caffeine on the activities of aspartate aminotransferase (AST), alanine amino transferase (ALT), gama glutamate transferase (γ-GT) enzymes in the sera. Caffeine demonstrated activation on (AST) and (ALT) activities, inhibitory effects on the (γ-GT) activity, and these effects increased with increasing the concentration of the compound. Kinetic properties of (AST) and (ALT) activities revealed (by caffeine) non-competitive type of activation, and of (γ-GT) activity competitive inhibitors

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Glucose-6-phosphatase (G6Pase), an enzyme found mostly in the kidneys and the liver, acting significant role of supplying glucose through starvation. This study includes (84) subjects, their age ranged from (40 to 54) years. (20) subjects were healthy chosen as control group and (64) patients with type 2 diabetes mellitus were divided into three groups according to their type of anti diabetic therapy : (23) newly diagnosed group without therapy (Group1), (20) with metformin therapy (Group2) and (21) with metformin plus glibenclamide therapies( Group3). The study found that G-6-Pase activity is increased, thereby leading to an increase in endogenous glucose production (EGP) in patients with type 2 diabetes and, therefore FPG will increase. The result found that increasing G-6-Pase activity will increase the concentration of glucose in the blood and that will increase the long-term glycemic control (HbA1c%).