1973
DOI: 10.1007/bf01219786
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Biochemical and morphological investigations of 30 human insulinomas

Abstract: Thirty human insulinomas have been investigated histologically and their immunoreaetive insulin (IRI) content estimated. In most eases immunohistological and ultrastruetural studies were also performed and the percentage of proinsulin-like components (PLC) in the tumour determined. Except for 1 ease the II~I concentration in the tumours was lower (0.01-89.0 U/g) than in the islet tissue. Histologically, immunohistologically and ultrastrueturally a variable number of tumour cells contained few and often no beta… Show more

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Cited by 189 publications
(47 citation statements)
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“…This tumor contained only 10 to 15% of the insulin content expected in a similar mass of isolated islet tissue. This is consistent with the high secretory rate indicated by this patient's abnormally high fasting plasma insulin level, and with reported insulin levels in 29 of 30 insulinomas studied by Creutzfeldt et al [28]. That secretory stimuli failed to increase insulin release either in the patient or in culture, in spite of an abnormally high insulin store, indicates a defective release mechanism; that neither the tumor nor cultured cells contained aldehyde fuchsin granules strengthens this hypothesis, and suggests that the defect might involve granule formation.…”
Section: Discussionsupporting
confidence: 77%
“…This tumor contained only 10 to 15% of the insulin content expected in a similar mass of isolated islet tissue. This is consistent with the high secretory rate indicated by this patient's abnormally high fasting plasma insulin level, and with reported insulin levels in 29 of 30 insulinomas studied by Creutzfeldt et al [28]. That secretory stimuli failed to increase insulin release either in the patient or in culture, in spite of an abnormally high insulin store, indicates a defective release mechanism; that neither the tumor nor cultured cells contained aldehyde fuchsin granules strengthens this hypothesis, and suggests that the defect might involve granule formation.…”
Section: Discussionsupporting
confidence: 77%
“…Our description of distinguishable insulin secretion patterns may represent the phenotypical expression of reported differences at the ultrastructural level [28,29]. Three decades ago, Creutzfeldt et al [28] published obvious ultrastructural characteristics with respect to the presence or absence of typical and atypical secretory granula in tumor cells of 30 insulinomas.…”
Section: Discussionmentioning
confidence: 99%
“…These are more likely to be malignant, but our results confirm that malignancy of insulinomas is not directly correlated with the degree of differentiation [7,9]. We have expressed the proinsulin proportion in terms of the sum of individual C-peptide and proinsulin assays.…”
Section: Discussionmentioning
confidence: 44%
“…Some insulinomas are histologically undifferentiated and secrete proinsulin rather than C-peptide and insulin [7,[13][14][15]. Assay of plasma C-peptide alone did not then adequately reflect beta cell secretion, and was not always abnormal in patients with insulinomas.…”
Section: Discussionmentioning
confidence: 99%
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