Biochemical challenge: difficult management of recurrent hypoglycaemia in the setting of a massive solitary fibrous tumour of the liver

Sawka, Alice; Toh, Dylan

doi:10.1111/imj.13819

Cited by 2 publications

(1 citation statement)

References 5 publications

(9 reference statements)

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“…15 Furthermore, selective arterial embolization of the tumor was previously reported in other cases, as a therapeutic alternative in unresectable tumors or a palliative measure for paraneoplastic hypoglycemia. [16][17][18] In the present case report, both strategies were combined to ensure glycemic control. Resolution of hypoglycemia was achieved without chemotherapy or other systemic treatments, which usually have low response rates.…”

Section: Discussionmentioning

confidence: 89%

Doege-Potter syndrome associated to metastatic solitary fibrous tumor

Andrade¹,

Sousa²,

Amaral³

et al. 2022

Autops Case Rep

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Solitary fibrous tumor (SFT) is a rare fibroblastic mesenchymal neoplasm with an estimated annual incidence of 0.35 per 100,000 individuals. Doege-Potter syndrome is a paraneoplastic syndrome related to solitary fibrous tumor clinically characterized by hypoglycemia, occurring in less than 5% of cases. Herein, we report a case of metastatic SFT associated with recurrent severe hypoglycemia. A 43-year-old male with a noncontributory medical history presented with a painless and progressive growing mass in the right thigh. The histological evaluation rendered the diagnosis of SFT, and tumor resection was performed. One year after the operation, on the oncological follow-up, he was admitted to the emergency unit, manifesting an early-morning seizure associated with a severe hypoglycemia. The laboratory findings of non-islet cell tumor hypoglycemia (NICTH) in the background of a relapsed metastatic solitary fibrous tumor were consistent with the diagnosis of Doege-Potter syndrome. Hepatic embolization associated with oral glucocorticoid was an efficient palliative treatment to control the hypoglycemic crisis and allow hospital discharge.

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