Intracranial solitary fibrous tumor/hemangiopericytomas: a clinical analysis of a series of 17 patients

Zhao, Cheng; He, Guoyuan; Wu, Zeyu; Rong, Jun; Ma, Fengchun; Wang, Zhichun; Fang, Jincheng; Gao, Wanwan; Song, Hong; Zhang, Fan; Di, Guangfu; Jiang, Xiaochun

doi:10.1080/02688697.2021.1944980

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…Solitary fibrous tumors (SFT) and hemangiopericytomas (HPC) are rare extra-axial tumors that have been classified as a single disease entity, that is, SFT/HPC, in the 2016 World Health Organization (WHO) guidelines. SFT/HPCs occasionally mimic meningioma but tend to lead to a worse overall prognosis and lower survival rate due to local recurrence and distant, extracranial metastasis [ 2 , 3 ]. The presence of bone erosion, absence of hyperostosis, sunburst flow void, and intratumoral calcification, and differing values of apparent diffusion coefficient have been proposed as radiological findings differentiating between meningiomas and SFT/HPCs [4] , [5] , [6] , [7] , [8] , [9] , [10] .…”

Section: Introductionmentioning

confidence: 99%

Are bone erosion and peripheral feeding vessels hallmarks of intracranial solitary fibrous tumor/hemangiopericytoma?

Sugiyama

Tsutsumi

Hashizume

et al. 2022

Radiology Case Reports

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Section: Introductionmentioning

confidence: 99%

Are bone erosion and peripheral feeding vessels hallmarks of intracranial solitary fibrous tumor/hemangiopericytoma?

Sugiyama

Tsutsumi

Hashizume

et al. 2022

Radiology Case Reports

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“…Zhao et al. also pointed out that two of five patients with recurrence had pathological malignant transformation in their study ( 24 ).…”

Section: Discussionmentioning

confidence: 90%

A pregnant woman with a giant bilateral parietal hemangiopericytoma underwent multiple surgeries and radiotherapy: a case report and literature review

Wu¹,

Xue²,

Wang³

et al. 2023

Front. Oncol.

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Intracranial hemangiopericytoma is a rare invasive tumor originating from mesenchymal fibroblasts and is prone to local recurrence and distant metastasis. This study reports a case of a 27-year-old woman who presented with severe headache, nausea and vomiting for two weeks at thirty-three weeks of gestation. Cranial magnetic resonance imaging (MRI) demonstrated a giant lesion in the bilateral parietal lobe with a size of 5.12x9.19x6.03 cm and severe edema in the surrounding brain tissue. The patient underwent four operations and 3 gamma knife radiosurgery procedures and is recovering well now. The histopathology findings showed hemangiopericytoma and STAT6 and CD34 positivity after the first and second surgeries. Because of tumor progression, the patient received gamma knife radiosurgery at 1, 3, and 4 years after the first operation. Total tumor resection was achieved in the fourth surgery. Nevertheless, the patient showed malignant transformation to from low-grade to high-grade hemangiopericytoma.

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“…STAT6 may be associated with the fusion of the NAB2-STAT6 gene caused by 12q chromosome rearrangement (25). Thus, detection of STAT6 or the NAB2-STAT6 fusion gene is recommended for the diagnosis of intracranial SFT (54)(55)(56). NAB2 and STAT6 are neighbour genes localized on the long arm of chromosome 12 and transcribed in opposite directions (57).…”

Section: Discussionmentioning

confidence: 99%

“…In SFT, an intrachromosomal inversion places the genes in the same orientation, which results in an in-frame fusion transcribed from the NAB2 promoter, leading to STAT6 nuclear expression that may be detected by IHC (14,57). The expression of STAT6 in intracranial SFT tissue was detected using IHC staining, and the NAB2-STAT6 fusion gene was accurately detected with both high specificity and sensitivity (54)(55)(56). STAT6 IHC is both a highly specific and sensitive surrogate for NAB2-STAT6 gene fusions, and the specificity and sensitivity of nuclear STAT6 for SFT/HPCs were 100 and 96.6%, respectively (20).…”

Section: Discussionmentioning

confidence: 99%

Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report

2023

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Solitary fibrous tumor (SFT) of the central nervous system is a rare spindle cell tumor of mesenchymal origin. The present study reports the case of a 44-year-old male patient with SFT. Magnetic resonance imaging demonstrated that the majority of the intracranial tumors exhibited uneven low signals on T1-weighted imaging (T1WI) and low mixed signals on T2WI, and there was an enhancement on enhanced scanning. Furthermore, the distal part of the left occipital lobe exhibited hypersignals on T1WI and T2WI, and this was significantly enhanced following enhanced scanning. The lower part of the scalp exhibited low signals on T1WI and high signals on T2WI, and there was no notable enhancement following enhanced scanning. Magnetic resonance spectroscopy demonstrated an elevated choline/creatine peak in the solid part of the tumor. Under the microscope, the tumor exhibited characteristic 'staghorn-shaped' blood vessels. As SFT is difficult to differentially diagnose via imaging, immunohistochemical analysis of CD34, vimentin and signal transducer and activator of transcription 6 was performed for the definitive diagnosis of SFT. Of note, surgical resection was the preferred treatment for SFT; however, due to the rarity of the tumor, subsequent adjuvant therapy and prognosis require further investigation.

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Intracranial solitary fibrous tumor/hemangiopericytomas: a clinical analysis of a series of 17 patients

Cited by 8 publications

References 32 publications

Are bone erosion and peripheral feeding vessels hallmarks of intracranial solitary fibrous tumor/hemangiopericytoma?

Are bone erosion and peripheral feeding vessels hallmarks of intracranial solitary fibrous tumor/hemangiopericytoma?

A pregnant woman with a giant bilateral parietal hemangiopericytoma underwent multiple surgeries and radiotherapy: a case report and literature review

Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report

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