Biochemical effects of dithiazanine on the canine whipworm, trichuris vulpis

Treatment of Trichuriasis with Dithiazanine

“…The anthelmintic effects of the cyanine dyes, and of dithiazanine in particular, have been investigated by Peters et al (1949) andby Swartzwelder et al (1957). It seems that the action of the cyanines is due to their interference with oxygen uptake and carbohydrate metabolism, and the fact that certain parasitic worms make use of enzyme systems different from those required by mammalian tissues.…”

“…It seems that the action of the cyanines is due to their interference with oxygen uptake and carbohydrate metabolism, and the fact that certain parasitic worms make use of enzyme systems different from those required by mammalian tissues. Bueding and Swartzwelder (1957) have shown that the "Lamidiniumr" ion system is responsible for inhibiting oxygen uptake in the filarial worm of the cotton-rat and that cyanine dyes cause an irreversible inhibition of anaerobic carbohydrate metabolism in Trichuris vulpis, the whipworm of dogs. In human trichuriasis the cyanines probably affect metabolism in the worm by inhibiting oxidative processes and also anaerobic reactions.…”

Biochemical Effects of the Anthelmintic Drug Mebendazole

“…ATP was determined in aliquots of the supernatants as proposed by Bueding et al ( 8 ) . After an incubation period of 24 hours the worms were homogenized in ice-cold 8 % perchloric acid, 1 worm per 20 ml of homogenizing medium.…”

Comparativee Biochemistry of Carbohydrates in Nematodes and Cestodes

“…For example, adult Schistosoma mansoni lives in the blood stream where an ample supply of oxygen is present. However, reports by Bueding et al (4 ) and Van den Bossche et al (5 ) indicate, that the dog whipworm, Trichuris vulpis and the small rat pinworm, Syphacia muris, respectively, may both possess predominantly anaerobic energy metabolisms. That is, all of the glucose dissimilated even aerobically can be accounted for as lactate, the only product formed.…”