Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Sanna, Andrea

doi:10.17957/ijab/15.1787

Cited by 3 publications

References 27 publications

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Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?

Erhunmwunse

Pajiah

Victory

et al. 2022

Preprint

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Imidacloprid is among the most widely used insecticides and may contaminate surface waters, yet there is limited information available on their effects on fish. In the present study, juvenile catfish (Clarias gariepinus) were exposed to 100, 130, 160, and 190 mg/L of imidacloprid for 96 hours, and the effects on mortality, behavior, hepatic and endocrine functions, oxidative stress, and tumor and inflammatory responses were investigated. The 96 hours LC50 was 166.60 (143.38-193.59 95% confidence intervals) mg/L with mortality recorded at concentrations ≥ 130 mg/L. Exposure to imidacloprid induced behavioral alterations and clinical symptoms including gulping, hypoactivity, abnormal surface distribution, loss of buoyancy, and excessive mucus secretion. Furthermore, amylase, lipase, conjugate bilirubin, carbohydrate antigen 19 − 9 (CA 19 − 9), thyroid stimulating hormone (TSH), and glutathione peroxidase (GPx) activity were significantly increased, while significant reductions were observed in triiodothyronine (T3) and superoxide dismutase (SOD) activity. Non-significant changes were observed in aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, 17β- estradiol (E2), thyroxine (T4), C-reactive protein (CRP), glutathione S-transferases (GST), total antioxidant capacity (TAC) and catalase (CAT) activity. Our results demonstrate that imidacloprid causes behavioral, hepatic, and endocrine toxicity in catfish as well as oxidative stress and tumor marker elevation. Our findings show that short-term exposure to imidacloprid triggers biochemical and physiological responses in juvenile catfish.

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Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?

Erhunmwunse

Pajiah

Victory

et al. 2022

Preprint

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Short-term imidacloprid exposure in juvenile fish triggers physiological and biochemical responses

Osazee,

Pajiah,

Ogodo

2024

Preprint

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The extensive use of systemic neonicotinoid insecticides in agriculture is a significant factor contributing to pollution in aquatic systems. Currently, there is no comprehensive data available on the effects of imidacloprid and other neonicotinoids on fish (Clarias gariepinus) biochemical and behavioral parameters. Several biomarkers, as well as mortality, behavioral alterations, and biochemical changes, were assessed to determine the impact of imidacloprid on Clarias gariepinus. The results demonstrated a substantial difference in fish mortality after exposure to imidacloprid (96-h LC50 = 166.60 mg/L) and the fish behavior varied with concentration and time of exposure. A significant difference (p = 0.0140) in mortality was observed in fish exposed to imidacloprid compared to the control. All exposed fish showed noticeable distress symptoms, represented by under-reactivity to stimulus, hypoventilation, gulping, abnormal surface distribution, and poor swimming movement. The GPx activity of control and exposed fish differed noticeably (p<0.05) at 130 mg/L. The alteration of several hepatic biomarkers of fish exposed to imidacloprid observed in this study indicates potential damage to the liver, which is a vital organ responsible for the detoxification and metabolism of xenobiotics. The results from this study could be used as a baseline for future research investigating the long-term effects of imidacloprid exposure on fish and other aquatic organisms

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Evaluation of Hemotoxic, Hepatotoxic and Nephrotoxic Potential of Profenofos-based Insecticide in Freshwater Labeo rohita Fish at Low Concentrations

Mahmood,

Ahmad,

Akmal

et al. 2023

PBMJ

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Profenofos, an organophosphate, is a major pollutant that pollutes freshwater bodies, causing significant impacts on fish health. Objective: Present study was performed to assess the toxicological impacts of pesticide profenofos on hematological, biochemical and histological alterations in different organs of Labeo rohita. Methods: Fish were divided in three groups. Group one was treated as control while second and third groups were exposed to 0.6 mg/L and 1.2 mg/L profenofos respectively for 28 days. Results: Results revealed that MCV, MCHC, MCH, RDW-SD, PCT, PDW, HGB, RBC and HCT levels were significantly reduced. WBC, RDW, PLT, MPV, neutrophils, lymphocytes, monocytes and eosinophils were increased as compared to pesticide free group. Biochemical results showed significant increase in cholesterol, triglycerides, AST, albumin, A/G ratio, HDL T3, T4, blood glucose, creatinine and urea levels were documented while levels of LDL, VLDL, ALT, total proteins, globulin, TSH and blood urea nitrogen (BUN) decreased significantly in exposed fish. Furthermore, histological changes in kidney, gills and liver of fish showed degenerative effects after exposure to profenofos in both concentrations. Conclusions: The present study concluded that profenofos resulted in widespread toxic effects on aquatic organisms specially fish.

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Biochemical, Endocrine and Genetic Impairments in Response to Agrochemicals Intoxication in Common Carp (Cyprinus carpio)

Cited by 3 publications

References 27 publications

Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?

Does short-term exposure to a Neonicotinoid insecticide trigger Biochemical and Physiological responses in Juvenile catfish?

Short-term imidacloprid exposure in juvenile fish triggers physiological and biochemical responses

Evaluation of Hemotoxic, Hepatotoxic and Nephrotoxic Potential of Profenofos-based Insecticide in Freshwater Labeo rohita Fish at Low Concentrations

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