Biochemical markers of hepatic fibrosis

Plebani, Mario; Burlina, Angelo

doi:10.1016/0009-9120(91)80013-s

Cited by 88 publications

(40 citation statements)

References 174 publications

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“…The results of this study indicated that the concentration of the circulating HA in dogs with liver cirrhosis is higher than that of dogs with non-cirrhotic liver disease. This result is in part consistent with the reports obtained with respect to humans [6,7,10,11,13], and suggests that the concentration of HA in canine blood may be a clinically important diagnostic test for dogs and may function as markers of cirrhosis in those with hepatic disease. HA concentration of group 1 was significantly higher than dogs with extrahepatic disease (group 3), although neither did we observe that HA concentration of group 1 was higher than that of the control group (Fig.…”

supporting

confidence: 91%

“…1) nor signified the correlation between the histological extent of hepatic fibrosis and blood HA level in group 1 (data not shown). In contrast, it has been reported that most of the human patients with hepatitis have higher HA concentration than the healthy controls and the degree of HA concentration is correlated to that of histological fibrosis [6,7,10,11,13]. In this study various types of hepatitis were included.…”

mentioning

confidence: 91%

“…Among them, hyaluronic acid (HA) or hyaluronan in blood is one of the reliable markers for liver fibrosis in human medicine [6,7,10,11,13] and its clinical usefulness has been reported. HA is a component of glycosaminoglycan, a major fraction of the extracellular matrix.…”

mentioning

confidence: 99%

“…HA is a component of glycosaminoglycan, a major fraction of the extracellular matrix. The concentration of HA in blood increases as fibrosis develops in patients with liver disease, especially in patients with liver cirrhosis [7,10,11,13,14]. Although the mechanism underlying this elevation in HA concentration is not fully understood, the synthesis of HA in activated hepatic stellate cells, the main fibrogenic cells in the diseased liver, and the reduced uptake of HA by the hepatic sinusoidal endothelial cells may play an important role [5,8,14,15].…”

mentioning

confidence: 99%

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Blood Hyaluronic Acid as a Marker for Canine Cirrhosis

Kanemoto

Ohno

Sakai

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Blood hyaluronic acid (HA) concentration was measured in dogs with various liver diseases to determine its relationship with histological fibrosis of the liver. The blood HA concentration significantly increased in dogs with chronic liver diseases compared with extrahepatic diseases and control. Furthermore, the median blood HA concentration in dogs with liver cirrhosis (500 g/l; range, 151-1970 g/l) was significantly higher than dogs with non-cirrhotic liver diseases (153 g/l; range, 15-477 g/l). In histochemical analysis, HA was distributed primarily in the fibrotic area in dogs with chronic liver diseases. As a conclusion, the blood HA concentration was significantly increased in dogs with chronic liver diseases, especially those with cirrhosis. Measurement of the blood HA levels of dogs with suspected liver disease can be a useful diagnostic aid for canine cirrhosis.KEY WORDS: canine liver, fibrosis, hyaluronic acid.

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confidence: 91%

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confidence: 91%

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confidence: 99%

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confidence: 99%

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Blood Hyaluronic Acid as a Marker for Canine Cirrhosis

Kanemoto

Ohno

Sakai

et al. 2009

The Journal of Veterinary Medical Science

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“…The amino peptide of type III Procollagen (PCP) is widely used as an index of hepatic necrosis and active fibrogenesis [12]. Previous investigators have demonstrated elevated levels of PCP in alcoholic cirrhosis patients [7].…”

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confidence: 99%

Carbohydrate Deficient Transferrin and Interleukin-6 as Predictors of Fibrosis in Alcohol Cirrhosis

et al. 2015

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The severity of alcoholic cirrhosis depends on the presence of liver inflammation and fibrogenesis. Previous studies have hypothesized that carbohydrate deficient transferrin can be used as marker of liver impairment in alcoholic liver disease patients. The present study was designed to assess whether carbohydrate deficient transferrin is associated with procollagen III peptide and predict fibrosis in alcohol cirrhosis patients. We enrolled 48 patients with alcoholic cirrhosis and 38 healthy controls. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 levels were estimated in both groups. Serum carbohydrate deficient transferrin, procollagen III peptide and interleukin-6 were significantly increased in alcoholic cirrhosis patients compared to controls. Stepwise regression analysis showed that carbohydrate deficient transferrin (adjusted R 2 = 0.313, b = 0.362, p = 0.003) and interleukin-6 (adjusted R 2 = 0.194, b = 0.459, p = 0.001) were positively associated with procollagen III peptide when age, duration and amount of alcohol consumption were considered as covariates. We conclude that elevated carbohydrate deficient transferrin and interleukin-6 act as predictors of fibrosis in alcoholic cirrhosis.

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