Biochemical Maturation of the Non-Innervated Chick Optic Lobe

Bondy, S. C.; Bonnet, K. C.; Harrington, Marilyn E.; Neurath, C. Z.; Nidess, Rael; Vernadakis, Antonia; Vulliet, Philip R; York, Curtis

doi:10.1159/000112552

Dev Neurosci

1978

DOI: 10.1159/000112552

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Biochemical Maturation of the Non-Innervated Chick Optic Lobe

S. C. Bondy¹,

K. C. Bonnet²,

Marilyn E. Harrington³

et al.

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1978

1989

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Cited by 3 publications

(2 citation statements)

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“…Hypoplasia then becomes increasingly obvious so that at the time of hatch, the non-innervated lobe is much smaller than the partner lobe which appears to develop normally (14). The experimental lobe has a reduced weight, DNA, RNA, and protein content (1,2). However, a considerable amount of biochemical differentiation can occur in the concentrations of choline acetyltransferase, tyrosine hydroxylase and nerve specific protein (NSP) in the developing non-innervated optic lobe.…”

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confidence: 99%

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Effects of prevention of afferentation of the development of the chick optic lobe

Bondy

Harrington

Anderson

1978

Brain Research Bulletin

Self Cite

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[411][412][413] 19711.-The effects of unilateral extirpation of the right optic cup of the three-day incubated chick embryo upon the rate of synthesis and the stability of DNA in the non-innervated optic lobe, have been studied. This surgical procedure prevents innervation of the optic lobe contralateral to the removed eye, while the other optic lobe is normally innervated by retinal ganglion cells of the remaining eye. At the 20th day of incubation, the DNA content of the non-innervated lobe was below that of the paired lobe receiving normal innervation. This deficiency of cell number was caused by two events; death of an excess number of neurons formed early in embryogenesis and a reduced rate of glial proliferation in the later stages of incubation. Non-innervationEnucleation Chick embryo

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mentioning

confidence: 99%

“…In addition, the blood-brain barrier of the non-innervated optic lobe appears to develop normally [2]. A partial maturation of high affinity neurotransmitter uptake mechanisms in the experimental lobe also occurs (1,2).…”

mentioning

confidence: 99%

Effects of prevention of afferentation of the development of the chick optic lobe

Bondy

Harrington

Anderson

1978

Brain Research Bulletin

Self Cite

View full text Add to dashboard Cite

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Reorganization of visual pathways following posthatching removal of one retina in pigeons

Bagnoli

Casini

Fontanesi

et al. 1989

J of Comparative Neurology

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Organization of visual pathways was studied in 2-month-old pigeons that underwent unilateral retinal removal on either the day of hatching (ERA, i.e., early retinal ablated) or the 9th day after hatching (LRA, i.e., late retinal ablated). A general size reduction of visual areas contralateral to the removed retina was found in ERA pigeons, which additionally showed an altered differentiation of thalamic visual targets as well as a different cytoarchitectonic arrangement of the superficial layers of the optic tectum. No comparable modifications were found in LRA pigeons. The retinal projections of the remaining eye were studied following intraocular injections of 3H-proline. Both in ERA and LRA pigeons, the distribution of retinofugal afferents to primary visual regions contralateral to the injected eye was similar to that of control pigeons. Anomalous ipsilateral projections from the remaining retina to primary retinorecipient regions were found in ERA pigeons only. Effects of early ablation of one retina on second-order visual connections were also studied. Following injections of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) into the visual Wulst contralateral to the operated eye, a smaller number of ipsilateral projecting thalamo-Wulst neurons was found as compared with control pigeons. In contrast, the contralateral thalamo-Wulst projections were increased. No changes in thalamo-Wulst projections were found following tracer injections into the opposite Wulst, i.e., ipsilateral to the operated eye. The present study demonstrates a substantial anatomical reorganization of both primary and secondary visual pathways following unilateral retinal removal immediately after hatching, when maturation of the visual system is not yet completed.

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The nuclear localization of a putative neurotransmitter receptor

1982

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Biochemical Maturation of the Non-Innervated Chick Optic Lobe

Cited by 3 publications

References 30 publications

Effects of prevention of afferentation of the development of the chick optic lobe

Effects of prevention of afferentation of the development of the chick optic lobe

Reorganization of visual pathways following posthatching removal of one retina in pigeons

The nuclear localization of a putative neurotransmitter receptor

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