Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port, Gabriela Z.; Oliveira, Kalinca da Silva; Soldera, Jonathan; Tovo, Cristiane Valle

doi:10.1590/s0004-28032014000100003

Cited by 12 publications

(15 citation statements)

References 34 publications

(49 reference statements)

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“…The reduction of plasma folate in HCC patients may have resulted from various factors. For example, the most common factors are under-nutrition and severe catabolic status which cancer patients suffer from, compromising the plasma folate status [ 14 ]. Moreover, a low folate status was reported to lead to liver damage through oxidative stress and pro-fibrogenic effect [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma

Cui

Quan

Piao

et al. 2016

IJMS

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Folate and vitamin B12 involved in the one-carbon metabolism may play a key role in carcinogenesis and progression of hepatocellular carcinoma (HCC) through influencing DNA integrity. The purpose of this study is to evaluate the association of plasma folate and vitamin B12 levels with HCC in a case-control study on 312 HCC patients and 325 cancer-free controls. Plasma concentrations of folate and vitamin B12 in all the subjects were measured by electrochemiluminescence immunoassay. Meanwhile, the information of HCC patients’ clinical characteristics including tumor-node-metastasis (TNM) stage, tumor size and tumor markers were collected. The patients of HCC had significantly lower folate levels than those of controls; there was no significant difference in the mean of plasma vitamin B12 levels. We also observed an inverse association between the levels of plasma folate and HCC: the adjusted odds ratios (OR) (95% confidence intervals (CI)) of HCC from the highest to lowest quartile of folate were 0.30 (0.15–0.60), 0.33 (0.17–0.65), and 0.19 (0.09–0.38). Compared to the subjects in the lowest quartile of plasma vitamin B12, only the subjects in the highest quartile of vitamin B12 exhibited a significant positive relationship with HCC, the adjusted OR was 2.01 (95% CI, 1.02–3.98). HCC patients with Stage III and IV or bigger tumor size had lower folate and higher vitamin B12 levels. There was no significant difference in the mean plasma folate levels of the HCC cases in tumor markers status (AFP, CEA and CA19-9 levels), whereas patients with higher CEA or CA19-9 levels retained significantly more plasma vitamin B12 than those with normal-CEA or CA19-9 level. In conclusion, plasma folate and vitamin B12 levels could be associated with HCC, and might be used as predictors of clinical characteristics of HCC patients. However, further prospective studies are essential to confirm the observed results.

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Section: Discussionmentioning

confidence: 99%

Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma

Cui

Quan

Piao

et al. 2016

IJMS

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“…Previous studies have shown a close association between UA production and non-alcoholic fatty liver disease (Li et al, 2009;Sirota et al, 2013), liver cancer (Port et al, 2014), and other liver diseases. Hepatocytes are the primary sites of UA generation.…”

Section: Introductionmentioning

confidence: 90%

Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes

et al. 2016

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ABSTRACT. Here, we investigated the effect of uric acid (UA) on hepatocyte mitochondria. Hepatocytes cultured in vitro were treated with varying concentrations of UA. The change in apoptotic activity was detected by flow cytometry. The DNA damage index 8-hydroxy-deoxyguanosine (8-OHdG) and mitochondrial function indices succinate dehydrogenase (SDH), cytochrome C oxidase (CCO), and adenosine triphosphate (ATP) were detected by enzyme assays. Reactive oxygen species (ROS) accumulation was confirmed by a dichloro-dihydrofluorescein diacetate assay. We observed an increase in apoptotic activity, ROS accumulation, and 8-OHdG activity in hepatocytes treated with UA for extended periods, indicating DNA damage; specifically, we observed a significant increase in these activities 48, 72, and 96 h after UA addition, compared to those observed at 24 h (P < 0.05). Cells treated with 30 mg/dL UA for 96 h showed a peak in apoptotic activity. We also observed a significant decrease in ATP, SDH, and CCO activities with the increase in uric acid concentration over time. Cells treated with 30 mg/dL UA for 96 h showed the highest ATP levels, while SDH and CCO activities at 48, 72, and 96 h post-UA treatment were significantly lower than those at 24 h (P < 0.01). Moreover, cells treated with 30 mg/dL UA showed a 0.02 ± 0.02 and 0.15 ± 0.01 mmol/ mg/min decrease in SDH and CCO levels after 72 h. Therefore, we concluded that high concentrations of UA may induce oxidative stress in hepatocyte mitochondria, increasing ROS production and ultimately resulting in mitochondrial damage.

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“…Factors such as anorexia and early satiety, triggered by changes in endogenous leptin, mineral deficiencies and reduction in gastric expandability favor a negative energetic balance, with an imbalance between ingestion and energy intake and expenditure, and PCM may develop as a result[ 14 ]. The zinc and magnesium deficiencies that may be often seen in the population of patients with cirrhosis contribute to the development of dysgeusia, which aggravates the intake capacity[ 15 , 16 ].…”

Section: Malnutrition In Cirrhosismentioning

confidence: 99%

Nutritional evaluation in cirrhosis: Emphasis on the phase angle

Fernandes¹,

Mattos²,

Tovo³

et al. 2016

WJH

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Protein-calorie malnutrition (PCM) is a common condition in cirrhotic patients, leading to a worse prognosis, complications, poor quality of life and lower survival rates. Among ways of assessing nutritional status, there are anthropometric methods such as the evaluation of the triceps skinfold, the arm circumference, the arm muscle circumference and the body mass index, and non-anthropometric methods such as the subjective global assessment, the handgrip strength of non-dominant hand, and the bioelectrical impedance analysis (BIA). PCM is frequently under-diagnosed in clinical settings in patients with cirrhosis due to the limitations of nutritional evaluation methods in this population. BIA is a useful method, but cannot be indicated in patients with abnormal body composition. In these situations, the phase angle (PA) has been used, and can become an important tool in assessing nutritional status in any situation. The PA is superior to anthropometric methods and might be considered as a nutritional indicator in cirrhosis. The early characterization of the nutritional status in patients with cirrhosis means an early nutritional intervention, with a positive impact on patients’ overall prognosis. Among the usually accepted methods for nutritional diagnosis, the PA provides information in a quick and objective manner.

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Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Cited by 12 publications

References 34 publications

Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma

Plasma Folate and Vitamin B12 Levels in Patients with Hepatocellular Carcinoma

Effect of uric acid on mitochondrial function and oxidative stress in hepatocytes

Nutritional evaluation in cirrhosis: Emphasis on the phase angle

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