Biochemical Predictors of Acute Kidney Injury in Critically Ill COVID-19 Patients

Samra, Tanvir; Ramachandran, Raja; Kumar, Vinod; Ray, Ananya; Mahajan, Varun; Ganesan, Rajarajan; B, Naveen Naik; Puri, Goverdhan Dutt; Bhalla, Ashish; Bhagat, Hemant

doi:10.1089/omi.2022.0144

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…The incidence of these two parameters was not as high as in the previously mentioned studies; however, it can predict adverse renal outcomes in long-term follow-up since Omicron infections may cause new kidney involvement [45]. for GLU [7,8,11]; for LEU (a) severe and critical COVID-19 [7,8,42], (b) COVID-19 AKI [25]; for KET [16]; for SG [4,5,10,16]; for BLOOD (a) severe and critical COVID-19 [7,8,10,11,29], (b) COVID-19 AKI [16,22,44], (c) COVID-19 mortality [14,16].…”

Section: Urine Biochemical Parameters For the Diagnosis And Predictio...mentioning

confidence: 89%

“…Especially in those patients requiring ICU support, AKI is associated with poor prognosis and increased risk of mortality. As a result of the studies mentioned above, we have observed that many laboratory parameters are useful as potential biomarkers to predict renal damage associated with COVID-19 [ 15 , 17 , 21 , 22 , 23 , 24 , 27 , 30 , 48 , 49 , 50 ].…”

Section: Methods: Identification and Characteristics Of Included Studiesmentioning

confidence: 99%

“…In addition, the simultaneous increase in combined PRO and haematuria correlated with mortality in COVID-19 patients [12]. for GLU [7,8,11]; for LEU (a) severe and critical COVID-19 [7,8,42], (b) COVID-19 AKI [25]; for KET [16]; for SG [4,5,10,16]; for BLOOD (a) severe and critical COVID-19 [7,8,10,11,29], (b) COVID-19 AKI [16,22,44], (c) COVID-19 mortality [14,16].…”

Section: Early Biomarkers Of Covid-19-related Akimentioning

confidence: 98%

“…Abbreviations: BLOOD, urine occult blood; PRO, proteinuria; GLU, glucose; LEU, leukocyturia; KET, ketones; SG, specific gravity; PH, potential of hydrogen. References: for PH [ 7 , 8 , 26 , 42 ]; for PRO (a) severe and critical COVID-19 [ 2 , 7 , 8 , 11 , 29 ], (b) COVID-19 AKI [ 25 ], (c) COVID-19 mortality [ 9 , 25 ]; for GLU [ 7 , 8 , 11 ]; for LEU (a) severe and critical COVID-19 [ 7 , 8 , 42 ], (b) COVID-19 AKI [ 25 ]; for KET [ 16 ]; for SG [ 4 , 5 , 10 , 16 ]; for BLOOD (a) severe and critical COVID-19 [ 7 , 8 , 10 , 11 , 29 ], (b) COVID-19 AKI [ 16 , 22 , 44 ], (c) COVID-19 mortality [ 14 , 16 ].…”

Section: Figurementioning

confidence: 99%

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Urine Parameters in Patients with COVID-19 Infection

Morello,

Amoroso,

Losacco

et al. 2023

Life

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A urine test permits the measure of several urinary markers. This is a non-invasive method for early monitoring of potential kidney damage. In COVID-19 patients, alterations of urinary markers were observed. This review aims to evaluate the utility of urinalysis in predicting the severity of COVID-19. A total of 68 articles obtained from PubMed studies reported that (i) the severity of disease was related to haematuria and proteinuria and that (ii) typical alterations of the urinary sediment were noticed in COVID-19-associated AKI patients. This review emphasizes that urinalysis and microscopic examination support clinicians in diagnosing and predicting COVID-19 severity.

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Section: Urine Biochemical Parameters For the Diagnosis And Predictio...mentioning

confidence: 89%

Section: Methods: Identification and Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Early Biomarkers Of Covid-19-related Akimentioning

confidence: 98%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Urine Parameters in Patients with COVID-19 Infection

Morello,

Amoroso,

Losacco

et al. 2023

Life

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Utility of Urinary Biomarkers for Diagnosis of Acute Kidney Injury (AKI) in COVID-19

Samra,

Kumar,

Ramachandran

et al. 2024

Ind J Clin Biochem

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Neutrophil-platelet ratio as a predictor of acute kidney injury in severe COVID-19

Sayan,

Altinisik,

Sayan

2024

Medicine

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Acute kidney injury (AKI) is one of the most seen complications of coronavirus-2019 (COVID-19) infection. Patients with AKI caused by COVID-19 likely have higher neutrophil counts and lower platelet and lymphocyte levels. Therefore, the predictive value of many inflammation indexes calculated from the total blood count has been investigated to predict the AKI in COVID-19. According to our clinical experience, we thought that neutrophilia and thrombocytopenia may be more common in the development of AKI. For this reason, this study aimed to evaluate the predictive value of the neutrophil-to-platelet ratio (NPR) for AKI in severe COVID-19 patients. This retrospective study included 334 severe COVID-19 patients followed up in the intensive care unit (ICU). Predictive factors for AKI were analyzed. ROC curve analysis was performed to determine the inflammation indexes’ cutoff values for the AKI prediction. Multivariate analyses were performed to determine correlations between the inflammation indexes and AKI. In this study, AKI was determined at the rate of 43% (n:145). Independent risk factors affecting AKI were determined to be age (HR = 1.047, 95% confidence interval [CI]: 1.021–1.072, P < .001), the need for invasive mechanical ventilation (HR = 3.003, 95% CI: 1.645–5.481, P = .001) and the need for vasopressor (HR = 8.111, 95% CI: 3.786–17.375, P < .001). The optimal cutoff values predicting AKI were determined to be 3.9 for the NPR (AUC = 0.679, 95% CI: 0.622–0.737, P < .001) with 71.7% sensitivity and 61.9% specificity, 16.1 for the neutrophil-to-lymphocyte ratio (NLR) (AUC = 0.634, 95% CI: 0.575–0.694, P < .001) with 65.5% sensitivity and 56.1% specificity, and 3872.5 × 109L for the systemic inflammatory index (SII) (AUC = 0.566, 95% CI: 0.504–0.629, P = .038) with 60% sensitivity and 55.6% specificity. In the regression model, only NPR values above the cutoff were related to AKI (HR = 3.817, 95% CI: 1.782–8.177, P = .001). The NPR has more predictive value than the NLPR, NLR, and SII in developing AKI in severe COVID-19 patients in the ICU. NPR is a new helpful index that can help clinicians predict early AKI in critical COVID-19.

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Biochemical Predictors of Acute Kidney Injury in Critically Ill COVID-19 Patients

Cited by 3 publications

References 25 publications

Urine Parameters in Patients with COVID-19 Infection

Urine Parameters in Patients with COVID-19 Infection

Utility of Urinary Biomarkers for Diagnosis of Acute Kidney Injury (AKI) in COVID-19

Neutrophil-platelet ratio as a predictor of acute kidney injury in severe COVID-19

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