Biochemical screening and mental retardation

Rao, B.S. Shankaranarayana; Jayasimha, N; Subhash, M. N.

doi:10.1007/bf02834424

Indian J Pediatr

1982

DOI: 10.1007/bf02834424

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Biochemical screening and mental retardation

B.S. Shankaranarayana Rao

N Jayasimha

M. N. Subhash

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1995

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Cited by 2 publications

References 9 publications

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Chromosomal and biochemical screening on mentally retarded school children in Taiwan

Wuu¹,

Chiu

et al. 1991

Jap J Human Genet

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SummaryGovernmental officials as well as medical scientists in Taiwan have worked hard in recent years to develop and to implement various measures, such as prenatal diagnosis and neonatal screening, to lower the incidence of hereditary diseases and mental retardation in the population. An inquiry into the possibility of devising a chromosomal and biochemical screening program and to apply it routinely to all the mentally retarded school children island-wide was the major aim of the present study. A collection of 1,614 blood samples was screened for phenylketonuria (PKU), galactosemia, homocystinuria, biotinidase deficiency, and congenital hypothyroidism. The IQ of these children ranged from 50-75 (1,397 children, moderate group) to less than 50 (217 children, severe group). Six cases of PKU (one tetrahydrobiopterin deficient and five classical) and three cases of thyroid dysfunction were found. The overall incidence of these two diseases was 0.56~. Of the 1,614 blood samples, 1,323 were cultured and karyotyped successfully. One hundred and twenty-five of them had chromosome abnormalities. The majority (64 out of 125) were trisomy 21. A remarkable difference in the percentage of mentally retarded children with chromosome abnormalities was observed between the moderate (7.87~) and severe (17.51~) retardates.

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Chromosomal and biochemical screening on mentally retarded school children in Taiwan

Wuu¹,

Chiu

et al. 1991

Jap J Human Genet

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Screening Procedures in Pediatrics

Raman

Gupta

1995

Medical Journal Armed Forces India

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Pediatric health screening procedures, both prenatal and postnatal, have a tremendous potential in improving the health status of children and in turn reducing the resource burden on the parents and the State. The existing recommendations, inherent problems and different screening procedures are discussed. The need for suitable mass screening pediatric procedures in the Indian context is stressed.

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Biochemical screening and mental retardation

Cited by 2 publications

References 9 publications

Chromosomal and biochemical screening on mentally retarded school children in Taiwan

Chromosomal and biochemical screening on mentally retarded school children in Taiwan

Screening Procedures in Pediatrics

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