Biochemical Studies in Myocardial Hypertrophy and Metabolic Support of the Acutely Stressed Myocardium

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

“…Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19]. The pharmacological effect of orotic acid is thought to rely on the activation of anaerobic metabolism through maintenance of glycogen stores, significant increase in protein synthesis, and nucleotide metabolism [20,21].…”