Biochemistry and Role of Sialic Acids

Schauer, Roland; Kelm, Sørge; Reuter, Gerd; Roggentin, Peter; Shaw, Lee

doi:10.1007/978-1-4757-9504-2_2

Cited by 188 publications

(218 citation statements)

References 283 publications

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“…The structure, occurrence and general functions of sialic acids have been extensively reviewed (20)(21)(22)(23)(24)(25). Some important functions attributed to sialic acids are : (1) sialic acids contribute significantly to the overall negative charge of cell surface and glycoproteins.…”

Section: What Sialic Acid Ismentioning

confidence: 99%

Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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Sialic acid, the acylated derivatives of 9-carbon sugar neuraminic acid, present as terminal component of oligosaccharide chains of many glycoproteins and glycolipids, has been recognized to be involved in the regulation of a great variety of biological phenomena. Studies have shown that serum sialic acid predicts both coronary heart disease and stroke mortality and reflects the existence or activity of an atherosclerotic process. Most of the studies have shown an elevation in serum sialic acid concentration in coronary heart disease and a positive correlation between the raised serum sialic acid and the severity of the coronary lesions is observed. However, a few contradictory reports are also available. Racial differences in serum sialic acid have also been reported and correlated with international differences in the prevalence of atherosclerosis. Reduced sialic acid content of platelets, erythrocytes and lipoproteins may play important role in the pathogenesis of atherosclerosis. Elucidation of the mechanism of alternation in sialic acid concentration may throw more light on its potential clinical utility. Hence more studies are needed to designate sialic acid as a cardiovascular risk factor / marker.

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Section: What Sialic Acid Ismentioning

confidence: 99%

Sialic acid in cardiovascular diseases

Nigam

Narain

Kumar

2006

Indian J Clin Biochem

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“…In eukaryotic organisms N-acetylneuraminic acid is a terminal component of glycan structures bound to proteins and gangliosides [1,2]. It is considered a molecular determinant of specific biological functions [3] such as cellular adhesion [4][5][6], formation or masking of recognition determinants [7][8][9][10] and stabilisation of glycoprotein structures [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Fax: (49) (30) 8 38 21 41. 1 The novel nucleic acid sequence data reported here have been submitted to the EMBL DataBase, European Bioinformatics Institute, accession number AJ238764. 2 These authors contributed equally to the results of this work.…”

Section: Introductionmentioning

confidence: 99%

Primary structure and expression analysis of humanUDP‐N‐acetyl‐glucosamine‐2‐epimerase/N‐acetylmannosamine kinase,the bifunctional enzyme in neuraminic acid biosynthesis¹

1999

FEBS Letters

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N-Acetylneuraminic acid is a main constituent of glycoproteins and gangliosides. In many membrane-bound receptors it is the target for external stimuli. The key enzyme for its biosynthesis is the bifunctional enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase, catalysing the first two steps of the biosynthesis in the cytosol. The rat enzyme was previously isolated and characterised. In this report we present the corresponding human cDNA sequence, compare it with the primary structure of the rodent enzyme, and report the analysis of its expression in different human tissues and cell lines.

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“…Sialic acids on the oligosaccharide chains of cell surface glycoconjugates in animals are involved in a number of intercellular recognition and adhesion processes [1,2]. This group of acidic sugars arises mainly from enzymatic derivatisation reactions on N-acetylneuraminic acid (Neu5Ac) [2].…”

Section: Introductionmentioning

confidence: 99%

CMP‐N‐acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron‐sulphur protein to be described in Eukarya

et al. 1996

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Electron paramagnetic resonance (EPR) spectroscopy and analysis of the primary structure of the CMP-Nacetylneuraminic acid hydroxylase revealed that this enzyme is the first iron-sulphur protein of the Rieske type to be found in the cytosol of Eukarya. The dithionite-reduced hydroxylase exhibited an EPR signal known to be characteristic for a Rieske ironsulphur centre (2Fe-2S), the g-values being 1.78, 1.91 and 2.01, respectively. An analysis of the primary structure of the hydroxylase led to the identification of an amino acid sequence, known to be characteristic for Rieske proteins. Furthermore, possible binding sites for cytochrome bs, the substrate CMPNeu5Ac and a mononuclear iron centre were also identified.

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Biochemistry and Role of Sialic Acids

Cited by 188 publications

References 283 publications

Sialic acid in cardiovascular diseases

Sialic acid in cardiovascular diseases

Primary structure and expression analysis of humanUDP‐N‐acetyl‐glucosamine‐2‐epimerase/N‐acetylmannosamine kinase,the bifunctional enzyme in neuraminic acid biosynthesis¹

CMP‐N‐acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron‐sulphur protein to be described in Eukarya

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Biochemistry and Role of Sialic Acids

Cited by 188 publications

References 283 publications

Sialic acid in cardiovascular diseases

Sialic acid in cardiovascular diseases

Primary structure and expression analysis of humanUDP‐N‐acetyl‐glucosamine‐2‐epimerase/N‐acetylmannosamine kinase,the bifunctional enzyme in neuraminic acid biosynthesis1

CMP‐N‐acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron‐sulphur protein to be described in Eukarya

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Primary structure and expression analysis of humanUDP‐N‐acetyl‐glucosamine‐2‐epimerase/N‐acetylmannosamine kinase,the bifunctional enzyme in neuraminic acid biosynthesis¹