Biochemistry of Brain Tumors

Wollemann, M

doi:10.1007/978-1-4615-7172-8_20

Cited by 13 publications

(7 citation statements)

References 91 publications

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“…OEF in the tumor was reported to be constantly lower than that in normal brain (30). This might be attributable to the dysfunction of certain redox enzymes in the tumor (50). Consequently, the true OGI in the tumor could be even lower than that estimated from this equation.…”

mentioning

confidence: 54%

Regional glucose utilization and blood flow in experimental brain tumors studied by double tracer autoradiography

et al. 1985

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Coupling of regional glucose utilization (GLU) and blood flow (CBF) was examined in rats with implanted brain tumors (AA ascites tumor) by quantitative double tracer autoradiography using 18F-2-fluorodeoxyglucose and 14C-iodoantipyrine. Four to 13 days after implantation, the animals were injected with the two tracers to obtain autoradiograms from the same brain section before and after the decay of 18F. The autoradiograms were then analyzed by an image processor to obtain a metabolic coupling index (MCI = GLU/CBF). In the tumor, high GLU and low CBF were uncoupled to give a high MCI which implied anerobic glycolysis. In large tumors, the CBF was even lower. In the peri-tumoral region, GLU was reduced (especially in gray matter) and reduction was lowest around the larger tumors. CBF in the peri-tumoral region was also reduced, but this reduction became less as the distance from the tumor margin increased. These changes in the peri-tumoral region may be secondary to edema. The GLU and CBF of white matter was little influenced by the presence of tumors except for some reduction in these values in relation to the larger tumors. On a narrow margin of tumor and brain, corresponding to a zone of increased vascularity, CBF was moderately high. The MCI in the tumor was higher than in the cortex of the same as well as the opposite hemisphere. These findings indicate that the metabolism and blood flow of the tumor and surrounding brain are variable and directly related to tumor size.

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mentioning

confidence: 54%

Regional glucose utilization and blood flow in experimental brain tumors studied by double tracer autoradiography

et al. 1985

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“…They suggest low amine levels in gliomas, meningiomas and neurinomas (Joyce 1963, Wolleman 1974. Since all these turnouts originate from elements other than nerve cells and there are no data demonstrating the presence of specific enzymes which synthesise eateeholamines or indoleamines, one may hypothesize that the low amine levels found in brain tumours originate outside the turnouts.…”

Section: Discussionmentioning

confidence: 96%

“…Cateeholamine metabolism has been extensively studied in patients with peripheral sympathetic tumonrs (Williams and Greet 1962, Studnitz et al 1963, Greet et al 1965, Bohuon and Guerinot 1966, Wolleman 1974. It is possible now to differentiate between the various tumours of the sympathetic nervous system, namely neuroblastomas, ganglioneuromas and phaeoehromoeytomas on the basis of the urinary excreted eateeholamine metabolites (Wolleman 1974).…”

Section: Discussionmentioning

confidence: 98%

Monoamine acid metabolites in ventricular CSF of patients with brain tumours

et al. 1976

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Homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) in ventricular CSF were determined in 19 patients (12 female 7 male) with brain tumours. No relationship was found between ventricular fluid pressure (VFP) and levels of HVA and 5-HIAA. A relationship was observed between ventricular CSF, HVA concentrations and tumour induced alterations in CSF dynamics. HVA concentrations were very high in patients whose tumours involved the third ventricle, the aqueduct, or the fourth ventricle, producing marked alterations in CSF flow. HVA concentrations significantly lower than in controls were observed in cases where tumours involved the lateral ventricles. Concentrations of acid metabolites in patients with little or no alteration in CSF dynamics corresponded with those in patients with other neurosurgical disorders.

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“…In summary, three 'high energy' drugs have been reviewed as support that a novel approach to the treatment of CNS malignancies could be through the inefficient energy system of brain tumors [11,12]. Anticancer agents that have the appropriate structure, can penetrate the CNS, not be recycled out and inhibit cancer growth.…”

Section: Resultsmentioning

confidence: 99%

“…A suggested platform for new novel agents -that might be effective therapies for brain tumors comes from the earlier 20 th century literature that focused on -'the energy of cancer cells vs. normal cells' [11][12][13].…”

Section: Landscape Analysis Of Drugs Available For Brain Tumorsmentioning

confidence: 99%

A Rational for Novel Anti-NeuroOncology Drugs

Morgan¹

2013

Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications

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Biochemistry of Brain Tumors

Cited by 13 publications

References 91 publications

Regional glucose utilization and blood flow in experimental brain tumors studied by double tracer autoradiography

Regional glucose utilization and blood flow in experimental brain tumors studied by double tracer autoradiography

Monoamine acid metabolites in ventricular CSF of patients with brain tumours

A Rational for Novel Anti-NeuroOncology Drugs

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