Bioclinical Test to Predict Nephropathia Epidemica Severity at Hospital Admission

Hentzien, Maxime; Mestrallet, S.; Halin, Pascale; Pannet, Laure-Anne; Lebrun, Delphine; Dramé, Moustapha; Bani‐Sadr, Firouzé; Galempoix, J.M.; Strady, C.; Reynes, Jean-Marc; Penalba, C; Servettaz, Amélie

doi:10.3201/eid2406.172160

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…In severe cases, kidney failure can develop [10]. NE presents in three forms: mild, moderate, and severe [11,12]. Each form of the disease progression includes febrile, oliguric, and polyuric periods, followed by convalescence.…”

Section: Introductionmentioning

confidence: 99%

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Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Shakirova

Khaertynova

Markelova

et al. 2022

BioMed Research International

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Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oliguric, and polyuric stages of the disease are also recognized. The patient’s cytokine responses have been suggested to play a central role in disease pathogenesis; however, little is known about the different patterns of cytokine expression in NE in cohorts of different ages and sexes. Serum samples and clinical records were collected from 139 patients and 57 controls (healthy donors) and were used to analyze 48 analytes with the Bio-Plex multiplex magnetic bead-based antibody detection kits. Principal component analysis of 137 patient and 55 controls (for which there was full data) identified two components that individually accounted for >15% of the total variance in results and together for 38% of the total variance. PC1 represented a proinflammatory TH17/TH2 cell antiviral cytokine profile and PC2 a more antiviral cytokine profile with patients tending to display one or the other of these. Severity of disease and stage of illness did not show any correlation with PC1 profiles; however, significant differences were seen in patients with high PC1 profiles vs. lower for a number of individual clinical parameters: High PC1 patients showed a reduced number of febrile days, but higher maximum urine output, higher creatinine levels, and lower platelet levels. Overall, the results of this study point towards a stronger proinflammatory profile occurring in younger NE patients, this being associated with markers of acute kidney injury and low levels of high-density cholesterol. This is consistent with previous work indicating that the pathology of NE is immune driven, with an inflammatory immune response being associated with disease and that this immune response is more extreme in younger patients.

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Section: Introductionmentioning

confidence: 99%

“…The severe form of NE is characterized by headache, vomiting, high fever (over 39.5 °C), and acute kidney injury. The most prominent clinical features of this form of NE are hemorrhagic symptoms including petechial, nasal, and internal bleeding [11][12][13]. The moderate form of the disease has similar symptoms but is more subtle.…”

Section: Introductionmentioning

confidence: 99%

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Shakirova

Khaertynova

Markelova

et al. 2022

BioMed Research International

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“…Particularly urinary IL-6 and urinary NGAL [12, 16] have been found to associate with the severity of AKI. The association of widely used C-reactive protein (CRP) with severe AKI in PUUV infection is less clear [17] [12]. We have previously found that the amount of proteinuria and hematuria in dipstick sample at the acute phase is associated with the severity of AKI in NE patients [18, 19].…”

Section: Introductionmentioning

confidence: 99%

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

et al. 2018

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BackgroundPuumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity.MethodsThis study included 79 patients hospitalized due to acute PUUV infection. Plasma resistin, leptin, adiponectin, as well as IL-6 and CRP, were measured at the acute phase, recovery phase and one year after hospitalization.ResultsPlasma resistin levels were significantly higher in the acute phase compared to the recovery phase and one year after (median resistin 28 pg/mL (11–107) vs. 17 pg/mL (7–36) vs. 14 pg/mL (7–31), p<0.001). Maximum resistin concentration correlated with maximum plasma creatinine levels (r = 0.63; p<0.001). The higher the amount of albuminuria in the urine dipstick test (0–1+, 2+ or 3+) at admission, the higher the median of maximum resistin (24.7 pg/mL, 25.4 pg/mL and 39.6 pg/mL, respectively, p = 0.002). High resistin was also an independent risk factor for severe AKI (creatinine ≥353.6μmol/L) (OR 1.08, 95% CI 1.02–1.14). Neither plasma leptin nor adiponectin level had any correlation with creatinine concentration or the amount of albuminuria.ConclusionsPlasma resistin independently associates with the severity of AKI in acute PUUV infection. The association of resistin with the amount of albuminuria suggests that the level of plasma resistin is not only influenced by renal clearance but could have some role in the pathogenesis of AKI during PUUV infection.

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Description of an outbreak of hemorrhagic fever with renal syndrome in the southern Jura Mountains, France, in 2021

Brun¹,

Greusard

Reynes

et al. 2023

Infectious Diseases Now

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Bioclinical Test to Predict Nephropathia Epidemica Severity at Hospital Admission

Abstract: This test identifies patients at low, intermediate, and high risk for severe disease.

Cited by 6 publications

References 40 publications

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

Description of an outbreak of hemorrhagic fever with renal syndrome in the southern Jura Mountains, France, in 2021

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