Biocompatibility and Anti-Microbiological Activity Characterization of Novel Coatings for Dental Implants: A Primer for Non-Biologists

Monsees, Thomas K.

doi:10.3389/fmats.2016.00040

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Biocompatibility refers to the question how these materials interact with the host. In general, it is assessed regarding biodegradation of materials, cytotoxicity toward eukaryotic and microbial cells, interaction with natural materials (e.g., teeth, bones) as well as inflammatory potentials, immunotoxicity, or mutagenicity [ 156 , 157 ]. Especially in the oral environment, devices should often last for decades with high durability and low level of biodegradation.…”

Section: Approaches For Biofilm Management In Dental Researchmentioning

confidence: 99%

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

et al. 2020

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Background All soft and solid surface structures in the oral cavity are covered by the acquired pellicle followed by bacterial colonization. This applies for natural structures as well as for restorative or prosthetic materials; the adherent bacterial biofilm is associated among others with the development of caries, periodontal diseases, peri-implantitis, or denture-associated stomatitis. Accordingly, there is a considerable demand for novel materials and coatings that limit and modulate bacterial attachment and/or propagation of microorganisms. Objectives and findings The present paper depicts the current knowledge on the impact of different physicochemical surface characteristics on bioadsorption in the oral cavity. Furthermore, it was carved out which strategies were developed in dental research and general surface science to inhibit bacterial colonization and to delay biofilm formation by low-fouling or “easy-to-clean” surfaces. These include the modulation of physicochemical properties such as periodic topographies, roughness, surface free energy, or hardness. In recent years, a large emphasis was laid on micro- and nanostructured surfaces and on liquid repellent superhydrophic as well as superhydrophilic interfaces. Materials incorporating mobile or bound nanoparticles promoting bacteriostatic or bacteriotoxic properties were also used. Recently, chemically textured interfaces gained increasing interest and could represent promising solutions for innovative antibioadhesion interfaces. Due to the unique conditions in the oral cavity, mainly in vivo or in situ studies were considered in the review. Conclusion Despite many promising approaches for modulation of biofilm formation in the oral cavity, the ubiquitous phenomenon of bioadsorption and adhesion pellicle formation in the challenging oral milieu masks surface properties and therewith hampers low-fouling strategies. Clinical relevance Improved dental materials and surface coatings with easy-to-clean properties have the potential to improve oral health, but extensive and systematic research is required in this field to develop biocompatible and effective substances.

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Section: Approaches For Biofilm Management In Dental Researchmentioning

confidence: 99%

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

et al. 2020

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“…There is no specific procedure for characterizing the biocompatibility of dental materials. Several researchers recommend using standardized testing procedures for the evaluation of the biocompatibility of medical devices [163,164]. Those documents include ANSI/ADA standard No.…”

Section: Biocompatibility Of Dental Dimethacrylate Polymer Networkmentioning

confidence: 99%

A Guide through the Dental Dimethacrylate Polymer Network Structural Characterization and Interpretation of Physico-Mechanical Properties

Barszczewska-Rybarek

2019

Materials

112

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Material characterization by the determination of relationships between structure and properties at different scales is essential for contemporary material engineering. This review article provides a summary of such studies on dimethacrylate polymer networks. These polymers serve as photocuring organic matrices in the composite dental restorative materials. The polymer network structure was discussed from the perspective of the following three aspects: the chemical structure, molecular structure (characterized by the degree of conversion and crosslink density (chemical as well as physical)), and supramolecular structure (characterized by the microgel agglomerate dimensions). Instrumental techniques and methodologies currently used for the determination of particular structural parameters were summarized. The influence of those parameters as well as the role of hydrogen bonding on basic mechanical properties of dimethacrylate polymer networks were finally demonstrated. Mechanical strength, modulus of elasticity, hardness, and impact resistance were discussed. The issue of the relationship between chemical structure and water sorption was also addressed.

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“…The function of a biomedical implant inside the human body is determined by its physical performance as well as the biological interaction. It is well-known that chemical, physical, and mechanical properties of the implant for a large part dictate the interaction with the human body in terms of biocompatibility and bioactivity. − However, in addition to the interaction with tissue cells, also interaction with other cells such as bacteria is often encountered giving rise to a biomaterial (implant) associated infection. , Therefore, the next generation of metallic implants not only needs to fulfill the biocompatibility and bioactivity but also needs to prevent infection. − Our earlier work on the improvement of titanium (Ti) implants has shown that synthesizing a smooth layer of calcium phosphate coating on Ti surface via electrochemical deposition, influences the cell adhesion and viability, and subsequently implant biocompatibility . However, calcium phosphate coatings are susceptible to bacterial infections caused by the adhesion and colonization of bacteria on the implant surface.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Electrodeposited Silver-Containing Calcium Phosphate Coatings

Mokabber

Cao

Norouzi

et al. 2020

ACS Appl. Mater. Interfaces

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Biocompatible antimicrobial coatings may enhance the function of many orthopedic implants by combating infection. Hydroxyapatite is a choice mineral for such a coating as it is native to bone and silver would be a possible antimicrobial agent as it is also commonly used in biomedical applications. The aim of the research is to develop a silver-containing calcium phosphate (Ag/Ca-P) coating via electrochemical deposition on titanium substrates as this allows for controlled coating buildup on complex shapes and porous surfaces. Two different deposition approaches are explored: one-step Ag/Ca-P(1) deposition coatings, containing silver ions as microsized silver phosphate particles embedded in the Ca-P matrix; and via a two-step method (Ag/Ca-P(2)) where silver is deposited as metallic silver nanoparticle on the Ca-P coating. The Ag/Ca-P(1) coating displays a bacterial reduction of 76.1 ± 8.3% via Ag-ion leaching. The Ag/Ca-P(2) coating displays a bacterial reduction of 83.7 ± 4.5% via contact killing. Interestingly, by preincubation in phosphate-buffered saline solution, bacterial reduction improves to 97.6 ± 2.7 and 99.7 ± 0.4% for Ag/Ca-P(1) and Ag/Ca-P(2) coatings, respectively, due to leaching of formed AgCl x (x–1)– species. The biocompatibility evaluation indicates that the Ag/Ca-P(1) coating is cytotoxic towards osteoblasts while the Ag/Ca-P(2) coating shows excellent compatibility. The electrochemical deposition of highly bactericidal coatings with excellent biocompatibility will enable us to coat future bone implants even with complex or porous structures.

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Biocompatibility and Anti-Microbiological Activity Characterization of Novel Coatings for Dental Implants: A Primer for Non-Biologists

Cited by 6 publications

References 41 publications

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

A Guide through the Dental Dimethacrylate Polymer Network Structural Characterization and Interpretation of Physico-Mechanical Properties

Antimicrobial Electrodeposited Silver-Containing Calcium Phosphate Coatings

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