Biocompatibility and bioactivity of PDLLA/TiO2 and PDLLA/TiO2/Bioglass® nanocomposites

Wei, J.Y.T.; Chen, Qizhi Z.; Stevens, Molly M.; Roether, Judith A.; Boccaccını, Aldo R.

doi:10.1016/j.msec.2007.01.004

Cited by 42 publications

(18 citation statements)

References 24 publications

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“…The bond energy of C-O, C-C and C-H in the molecular chain of PLA is about 326 kJ/mol, 332 kJ/mol and 414 kJ/mol respectively, while the energies of outdoor ultraviolet (UV) at 200 nm and 300 nm are 598 kJ/mol and 397 kJ/mol. PLA can be easily damaged by UV when it is used outdoor, limiting the application of PLA [16][17][18][19][20]. To prevent from the possible degradation, UV response additives, such as ZnO and TiO 2 , can be incorporated into PLA matrix resin.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Preparation and UV-protective property of PVAc/ZnO and PVAc/TiO2 microcapsules/poly(lactic acid) nanocomposites

Zhang

Han

2016

Fibers Polym

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The poly(vinyl acetate) (PVAc)/zinc oxide (ZnO) microcapsule and PVAc/titanium dioxide (TiO 2 ) microcapsule were synthesized via in-situ emulsion polymerization method. The PVAc/ZnO microcapsule and PVAc/TiO 2 microcapsule were characterized by fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis(TG), transmission electron microscopy (TEM), and UV-visible spectroscopy (UV-vis). Effect of PVAc/ZnO microcapsule and PVAc/TiO 2 microcapsule on properties of poly(lactic acid) (PLA) was evaluated by UV-vis, SEM and mechanical properties test. The results showed that the addition of PVAc/ZnO and PVAc/TiO 2 microcapsules as a UV-blocking additive could significantly enhance UVblocking property of PLA/PVAc/ZnO microcapsule composites and PLA/PVAc/TiO 2 microcapsule composites compared with pure PLA, PLA/ZnO composites and PLA/TiO 2 composites. The mechanical properties of PLA/PVAc/ZnO microcapsule composites were better than those of PLA/ZnO composites due to good dispersability and compatibility of PVAc/ZnO microcapsule in PLA matrix. Also, the mechanical properties of PLA/PVAc/TiO 2 microcapsule composites were better than those of pure PLA and PLA/TiO 2 composites. This study demonstrates the great potentials of the intrinsically UV shield additive PVAc/ZnO and PVAc/TiO 2 microcapsules in the application of high performance matrix resin and composite material.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Preparation and UV-protective property of PVAc/ZnO and PVAc/TiO2 microcapsules/poly(lactic acid) nanocomposites

Zhang

Han

2016

Fibers Polym

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“…18 It is reported that poly (D, L lactic acid) film containing 20 wt% TiO 2 could improve the formation of hydroxyapatite (HA) after 21 days' exposure to simulated body fluid and increase the relative metabolic activity of MG-63 cells after seven days of incubation. 19 All the aforementioned studies suggest that the excellent biocompatibility and bioactivity of n-TiO 2 composites is due mainly to the favorable bioactivity of TiO 2 nanoparticles in composites and the surface morphology of the TiO 2 layer. The aim of this study was to utilize n-TiO 2 to improve the bioactivity of PEEK and to investigate the bioactivity of n-TiO 2 /PEEK composites both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Liu²,

Wei³

et al. 2012

IJN

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Background: Compared with titanium (Ti) and other metal implant materials, poly(ether-ether ketone) (PEEK) shows outstanding biomechanical properties. A number of studies have also reported attractive bioactivity for nano-TiO 2 (n-TiO 2 ). Methods: In this study, n-TiO 2 /PEEK nanocomposites were prepared, taking advantage of the unique properties of both PEEK polymer and n-TiO 2 . The in vitro and in vivo bioactivity of these nanocomposites was assessed against a PEEK polymer control. The effect of surface morphology or roughness on the bioactivity of the n-TiO 2 /PEEK nanocomposites was also studied. n-TiO 2 /PEEK was successfully fabricated and cut into disks for physical and chemical characterization and in vitro studies, and prepared as cylindrical implants for in vivo studies. Their presence on the surface and dispersion in the composites was observed and analyzed by scanning and transmission electron microscopy and X-ray photoelectron spectroscopy. Results: Bioactivity evaluation of the nanocomposites revealed that pseudopods of osteoblasts preferred to anchor at areas where n-TiO 2 was present on the surface. In a cell attachment test, smooth PEEK showed the lowest optical density value (0.56 ± 0.07) while rough n-TiO 2 /PEEK exhibited the highest optical density value (1.21 ± 0.34, P , 0.05). In in vivo studies, the percent bone volume value of n-TiO 2 /PEEK was approximately twice as large as that of PEEK (P , 0.05). Vivid three-dimensional and histologic images of the newly generated bone on the implants further supported our test results. Conclusion: Our study demonstrates that n-TiO 2 significantly improves the bioactivity of PEEK, especially if it has a rough composite surface. A n-TiO 2 /PEEK composite with a rough surface could be a novel alternative implant material for orthopedic and dental applications.

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“…In the same year, several studies regarding bone tissue engineering were published (Erisken et al, 2008-b;Guan et al, 2008;Nejati et al, 2008;Schneider et al, 2008;Duan et al, 2008;Wei et al, 2008). An interesting PHB-based scaffold containing nanosized hydroxyapatite was developed by Guan and co-workers by gas-jet/electrospinning.…”

Section: Current Applications In Tissue Engineering and Regenerative mentioning

confidence: 99%

Nano-Doped Matrices for Tissue Regeneration

Ricotti¹,

Ciofani²,

Mattoli³

et al. 2011

Advances in Regenerative Medicine

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Biocompatibility and bioactivity of PDLLA/TiO2 and PDLLA/TiO2/Bioglass® nanocomposites

Cited by 42 publications

References 24 publications

RETRACTED ARTICLE: Preparation and UV-protective property of PVAc/ZnO and PVAc/TiO2 microcapsules/poly(lactic acid) nanocomposites

RETRACTED ARTICLE: Preparation and UV-protective property of PVAc/ZnO and PVAc/TiO2 microcapsules/poly(lactic acid) nanocomposites

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Nano-Doped Matrices for Tissue Regeneration

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