Biocompatibility and biomechanical analysis of elastic TPU threads as new suture material

Abstract

High suture tension is one of the causes for many wound-healing problems. Constriction of tissue within the suture loops of nonelastic sutures can lead to cutting of the suture through tissues and necrosis of the tissue within these loops. The use of elastic materials in new suture types could give the material the ability to adapt tension to the tissue requirements and subsequently lead to more vital tissue within its loops. We evaluated the foreign body host response, as indicator of biocompatibility, to a new thermoplastic poly(carbonate) urethane (TPU) synthetic suture material in a rat model compared with standard nonelastic polypropylene (PP) sutures. Tissue samples were collected at 7 and 21 days, and host response was evaluated. Subsequently, suture tension curves of the new elastic sutures for the first 30 min after knotting were recorded in a pig model. The new TPU sutures showed an improved foreign body response when compared with that of PP, with a reduction in the amount of macrophages surrounding the material. Tension experiments showed a superior tension curve for TPU sutures, with a major reduction in peak suture tension when compared with that of standard PP sutures, while still retaining adequate tension after 30 min. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 99-106, 2017.

Improved biocompatibility of profiled sutures through lower macrophages adhesion

“…The degree of FBG, which represents the host response with inflammation and fibrotic remodeling, directly correlates with mesh‐associated complications as pain and infection . The FBG was formed according to Klink et al as an inner granuloma, which mainly consists of macrophages, and an outer granuloma (fibrotic capsule) with comet‐tails called elongations on two opposing sides. In order to induce FBG originating mainly from the host reaction of the material itself and to minimize trauma‐caused inflammatory reactions, the material was implanted in the subcutaneous tissue in tension free conditions .…”

Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering

“…Statistical analysis was performed using one‐way analysis of variance (ANOVA) with post hoc Fisher test for DNA content, CellTiter‐Blue®, and real‐time qPCR, unless stated otherwise. One‐way ANOVA with post hoc Fisher's test has been widely used in literature when comparing a large range of variable sizes (Bédouin, Gordin, Pellen‐Mussi, et al, ; Nayak & Brenner, ; Vogels et al, ; Woods & Gratzer, ).…”

Mesh Sutured Repairs of Abdominal Wall Defects

“…Experimental evidence shows that the foreign body response recedes when the foreign body disappears, 20 , 21 and this may explain why abdominal wall scars after laparotomy and closure with absorbable sutures are only 70% as strong as unscarred linea alba. 22 Foreign body-induced scar from implanted polypropylene 23 is localized to the site of abdominal wall closure and magnified by the high surface area. Our hernia recurrence rate of <4% at the early mean follow-up time of 234 days is encouraging and is much less than expected, when compared to a cohort of similarly complex sutured repairs performed by the senior author.…”