Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow

Bueno, Carlos Roberto Emerenciano; Vasques, Ana Maria Veiga; Cury, Marina Tolomei Sandoval; Sivieri-Araújo, Gustavo; Jacinto, Rogério de Castilho; Gomes‐Filho, João Eduardo; Cintra, Luciano Tavares Ângelo; Dezan, Elói

doi:10.1007/s00784-018-2423-0

Cited by 51 publications

(78 citation statements)

References 36 publications

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“…Although the particle size was not the target of this study, Bio‐C Pulpo shows consistency similar to a modelling mass, not sandy, similar to the characteristics observed by Bueno et al . () when mixing MTA Flow™. On the other hand, MTA has larger particles that make the handling of the material more challenging.…”

Section: Discussionmentioning

confidence: 99%

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Biocompatibility and immunohistochemical evaluation of a new calcium silicate‐based cement, Bio‐C Pulpo

Cosme‐Silva¹,

Gomes‐Filho²,

Benetti³

et al. 2019

Int Endodontic J

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Aim To evaluate the inflammatory response and ability to induce mineral deposition through histological and immunohistochemical analysis for osteocalcin (OCN), osteopontin (OPN) and bone sialoprotein (BSP) of a new calcium silicate‐based cement, Bio‐C Pulpo (Angelus), compared to white mineral trioxide aggregate (White MTA‐Ang) (Angelus). Methodology Polyethylene tubes containing Bio‐C Pulpo and White MTA‐Ang as well as empty tubes were implanted into the dorsal connective tissue of 30 Wistar rats, which were arranged in five groups according to the period of analysis: 7, 15, 30, 60 and 90 days. After each experimental period, the tubes with surrounding tissue were removed and histologically processed to be analysed using haematoxylin–eosin and immunohistochemistry for the detection of OCN, OPN and BSP. The data were statistically analysed (Friedman's test) at a 5% significance level. Results The inflammatory response observed with Bio‐C Pulpo and White MTA‐Ang was greater after 7 and 15 days and decreased from 30 days onwards. No significant difference was found between the control, Bio‐C Pulpo and White MTA‐Ang at the different periods of analysis (P > 0.05). The immunolabelling for OCN, OPN and BSP was more intense for Bio‐C Pulpo and White MTA‐Ang after 60 and 90 days, but there was no difference between Bio‐C Pulpo and White MTA‐Ang at the different periods of analysis (P > 0.05). Conclusion Bio‐C Pulpo is biocompatible and induces immunolabelling of osteogenic markers such as OCN, OPN and BSP similar to White MTA‐Ang.

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Section: Discussionmentioning

confidence: 99%

“…) and MTA Flow™ (Ultradent Products Inc., South Jordan, UT, USA; Bueno et al . ) have been indicated for pulpotomy. However, MTA is considered the gold standard for pulpotomies and other clinical applications due to its biocompatibility and ability to stimulate mineral deposition (Gomes‐Filho et al .…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and immunohistochemical evaluation of a new calcium silicate‐based cement, Bio‐C Pulpo

Cosme‐Silva¹,

Gomes‐Filho²,

Benetti³

et al. 2019

Int Endodontic J

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“…Tricalcium silicate‐based sealers have recently become popular for root canal obturation owing to their biocompatibility, biomineralization capacity, and increased sealing ability compared to the conventional root canal sealers (Asawaworarit, Yachor, Kijsamanmith, & Vongsavan, ; Bueno et al, ; Gomes‐Filho, Watanabe, Bernabé, & de Moraes Costa, ). MTA Fillapex (Angelus, Londrina, Brazil), is the first generation tricalcium silicate‐based sealer containing MTA, salicylate resin, natural resin, bismuth trioxide, and silica.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of different irrigation protocols in removing tricalcium silicate‐based sealers from simulated root canal irregularities

et al. 2019

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Objective The aim of this study was to evaluate the efficacy of different irrigation protocols in removing two tricalcium silicate‐based sealers from simulated root canal irregularities and root canal walls. Material and methods Root canals of 140 single‐rooted teeth were instrumented. In one‐half of each root, an apical groove was created. The samples were divided into two main groups (n = 70) based on the sealer used. In group 1, the grooves were filled with MTA Fillapex; in group 2, BioRoot RCS. The reassembled root halves were divided into six experimental and one control groups: 2.5% NaOCl‐17% EDTA (Passive ultrasonic irrigation [PUI]), 5% NaOCl/9% DualRinse HEDP (PUI), 2.5% NaOCl‐7% Maleic acid (PUI), 2.5% NaOCl‐17% EDTA (Er:YAG laser activated irrigation [LAI]), 2.5% NaOCl/9% DualRinse HEDP (LAI), 2.5% NaOCl‐7% Maleic acid (LAI), Distilled water (Control). Specimens were scored using SEM. The data were analysed using Kruskal‐Wallis and Mann Whitney U tests. Results Maleic acid and DualRinse HEDP removed higher amounts of MTA Fillapex from the grooves compared to EDTA, when used with both activation methods (p < .001). Conclusions Ultrasonically activated maleic acid or DualRinse HEDP can be an effective irrigation regimen in removing tricalcium silicate‐based sealers.

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“…, Bueno et al . ). Thick MTA Flow had a less irritation on the adjacent tissue, and, consequently, faster repair when compared with fluid MTA and Biodentine.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, it was reported that MTA Flow was biocompatible and induced biomineralization (Bueno et al . ). However, the authors did not evaluate MTA Flow in different powder/gel ratios.…”

Section: Introductionmentioning

confidence: 97%

Biocompatibility of mineral trioxide aggregate flow and biodentine

et al. 2018

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Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow

Abstract: The final consistence obtained in MTA Flow may facilitate several procedures, indicating that the MTA Flow has a promising application in endodontics.

Cited by 51 publications

References 36 publications

Biocompatibility and immunohistochemical evaluation of a new calcium silicate‐based cement, Bio‐C Pulpo

Biocompatibility and immunohistochemical evaluation of a new calcium silicate‐based cement, Bio‐C Pulpo

The efficacy of different irrigation protocols in removing tricalcium silicate‐based sealers from simulated root canal irregularities

Biocompatibility of mineral trioxide aggregate flow and biodentine

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