Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes

Kim, E V; Petronyuk, Yu. S.; Guseynov, N. A.; Tereshchuk, S V; Попов, А. А.; Volkov, A. V.; Gorshenev, V. N.; Olkhov, A. A.; Levin, V. M.; Дымников, А. Б.; Rodionov, V. E.; Tumanyan, G A; Ивашкевич, С. Г.; Бонарцев, А. П.; Borozdkin, L. L.

doi:10.1007/s10517-021-05066-x

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…Regarding the biodegradability of membranes in rats, Lumina-Coat confirmed the stability time of 4 to 6 weeks 11,31 , falling short of the Lumina-Coat Double Time, stable up to 8 weeks 50,56 . Surgitime PTFE did not show resorption during the experiment, as expected for the synthetic polymer PTFE 11,12,24,32,53 . Despite GenDerm being well organized, with high tensile strength and less deformation compared to Lumina-Coat and Surgidry Dental F, internal cracks explain structural fragility and greater subcutaneous degradation, predicted for up to 45 days 11,33 .…”

Section: Discussionsupporting

confidence: 73%

“…Natural composite membranes with collagen and apatite also exhibit fibrogenesis similar to collagen biopolymers 17,50,52 . On the other hand, synthetic polymers present connective tissue formation dependent on the degradability pattern, in a lower fibrogenesis scale in non-resorbable biomaterials (e.g., PTFE) 11,12,24,47,53 and higher in resorbable ones (e.g., PLGA) 13,24,45,47,54,55 . None of the experimental groups had a foreign body granuloma (nonimmunogenic) with a fibrous capsule, which is considered an unwanted implant rejection response 17,18,47 .…”

Section: Discussionmentioning

confidence: 99%

“…Polymeric GBR membranes are the most used in the biomedical area 7,9,10 . Synthetic membranes include polytetrafluoroethylene (PTFE), resistant to degradation, bioinert, chemically stable, porous and flexible, and poly(lactic acid-co-glycolic acid) (PLGA), which has controlled degradation [11][12][13] . Natural membranes are usually of collagen, a biomimetic composition to favor the bone repair process [14][15][16][17] , with excellent biocompatibility, variable biodegradability 7,18 and extraction sources, such as tendon, cortical bone or bovine pericardium 11,19,20 or porcine submucosa 21,22 .…”

Section: Introductionmentioning

confidence: 99%

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Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects

et al. 2023

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To evaluate the in vivo efficiency of commercial polymeric membranes for guided bone regeneration. Methods: Rat calvarial critical size defects was treated with LuminaCoat (LC), Surgitime PTFE (SP), GenDerm (GD), Pratix (PR), Techgraft (TG) or control (C-) and histomorphometric analysis determined the percentage of new bone, connective tissue and biomaterial at 1 or 3 months. Statistical analysis used ANOVA with Tukey's post-test for means at same experimental time and the paired Student's t test between the two periods, considering p < 0.05. Results: New bone at 1 month was higher for SP, TG and C-, at 3 months there were no differences, and between 1 and 3 months PR had greater increase growthing. Connective tissue at 1 month was higher for C-, at 3 months for PR, TG and C-, and between 1 and 3 months C-had sharp decline. Biomaterial at 1 month was higher for LC, in 3 months for SP and TG, and between 1 and 3 months, LC, GD and TG had more decreasing mean. Conclusion: SP had greater osteopromotive capacity and limitation of connective ingrowth, but did not exhibit degradation. PR and TG had favorable osteopromotion, LC less connective tissue and GD more accelerated biodegradation.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects

et al. 2023

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“…3D-prototyping of bone implant Currently, it is possible to produce a biocompatible bone implant (scaffold) of any geometric shape, including an individual one for each particular patient using 3D-printing , Kim et al, 2021.…”

Section: Discussionmentioning

confidence: 99%

Tissue-Engineered Bone Implants for the Replacement of Jawbone Defects. Literature Review

Kobets

Kazaryan

Bopkhoev

2022

IJIM

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The purpose of the study: to trace the development of methods of bone implants for the replacement of jawbone defects: from ceramic and polymeric scaffolds to complex tissue-engineered structures with stem cells, growth factors and vascular anastomoses based on literature data.Materials and methods: searching, systematization and analysis of scientiﬁc data on various types of 3D-printed bone implants and their effectiveness in replacing bone defects.Conclusions: Modern technologies of 3D-printing, cell and tissue engineering, microvascular surgical techniques closely approach scientists and clinicians to creation of an artiﬁcial bone implant which in the body must become a living structure capable of integrating with the patient’s bone. Only complex approach which includes reconstruction of the implant of individual shape and sufﬁcient mechanical strength, giving of osteoinductive and osteogenic properties, providing of internal axial and external angiogenesis is the basis for such tissue-engineered construction.

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“…ROG(KIM et al, 2021;TAYEBI et al, 2018).O acesso comercial às membranas regenerativas na atualidade é amplo, mesmo em domínios eletrônicos de revenda não prioritários do mercado odontológico. Entretanto, a oferta de tais produtos no Brasil ainda é bem limitada diante da exuberância de evidências científicas, com maior prevalência de membranas reabsorvíveis sobre as não reabsorvíveis.…”

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Odontologia: pesquisa e práticas contemporâneas - Volume 1

Fadel¹,

Martins²,

Pinheiro³

2021

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Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes

Cited by 12 publications

References 7 publications

Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects

Efficiency analysis of commercial polymeric membranes for bone regeneration in rat cranial defects

Tissue-Engineered Bone Implants for the Replacement of Jawbone Defects. Literature Review

Odontologia: pesquisa e práticas contemporâneas - Volume 1

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