Biocompatibility and biosafety of butterfly wings for the clinical use of tissue-engineered nerve grafts

Peripheral nerve injury (PNI) is a severe clinical disease leading to the loss of sensory and motor function and even lifelong disability of patients. Nerve scaffolds with conductive materials are beneficial to PNI repair and regeneration through the recovery of electrical signals transmission and regulation of nerve cell membrane function. In this study, composite poly(lactide‐co‐glycolide) (PLGA)/Ti3C2Tx (MXene) membranes with different content of MXene were fabricated by electrospinning, and these fibrous membranes showed favorable mechanical property for supporting nerve regeneration. With loaded MXene, the electrospun membranes exhibited good antibacterial property that the antimicrobial rate was as high as 80%, which is conducive to the prevention of wound inflammation after stent implantation. The loaded MXene also improved the hydrophilicity and conductivity of the electrospun composite membranes, which provided good biocompatibility for cell growth. Interestingly, treating in 75% ethanol solution made fabricated PLGA/MXene membranes rapidly crimp into stable nerve conduits for implanted application. These fabricated PLGA/MXene membranes showed good potential for nerve repair and have a good prospect for nerve conduit application.

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Conductive and antibacterial scaffold with rapid crimping property for application prospect in repair of peripheral nerve injury

Zhang

Lan

et al. 2022

J of Applied Polymer Sci

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Engineering a conduction‐consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell‐derived cardiomyocytes

Tan

Chen

et al. 2023

Bioengineering & Transla Med

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Engineering a conduction‐consistent cardiac patch has direct implications to biomedical research. However, there is difficulty in obtaining and maintaining a system that allows researchers to study physiologically relevant cardiac development, maturation, and drug screening due to the issues around inconsistent contractions of cardiomyocytes. Butterfly wings have special nanostructures arranged in parallel, which could help generate the alignment of cardiomyocytes to better mimic the natural heart tissue structure. Here, we construct a conduction‐consistent human cardiac muscle patch by assembling human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) on graphene oxide (GO) modified butterfly wings. We also show this system functions as a versatile model to study human cardiomyogenesis by assembling human induced pluripotent stem cell‐derived cardiac progenitor cells (hiPSC‐CPCs) on the GO modified butterfly wings. The GO modified butterfly wing platform facilitated the parallel orientation of hiPSC‐CMs, enhanced relative maturation as well as improved conduction consistency of the cardiomyocytes. In addition, GO modified butterfly wings enhanced the proliferation and maturation characteristics of the hiPSC‐CPCs. In accordance with data obtained from RNA‐sequencing and gene signatures, assembling hiPSC‐CPCs on GO modified butterfly wings stimulated the differentiation of the progenitors into relatively mature hiPSC‐CMs. These characteristics and capabilities of GO modified butterfly wings make them an ideal platform for heart research and drug screening.

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A comprehensive bench-to-bed look into the application of gamma-sterilized 3D-printed polycaprolactone/hydroxyapatite implants for craniomaxillofacial defects, an in vitro, in vivo, and clinical study

Babaei,

Ebrahim-Najafabadi,

Mirzadeh

et al. 2024

Biomaterials Advances

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Biocompatibility and biosafety of butterfly wings for the clinical use of tissue-engineered nerve grafts

Cited by 7 publications

References 41 publications

Conductive and antibacterial scaffold with rapid crimping property for application prospect in repair of peripheral nerve injury

Conductive and antibacterial scaffold with rapid crimping property for application prospect in repair of peripheral nerve injury

Engineering a conduction‐consistent cardiac patch with graphene oxide modified butterfly wings and human pluripotent stem cell‐derived cardiomyocytes

A comprehensive bench-to-bed look into the application of gamma-sterilized 3D-printed polycaprolactone/hydroxyapatite implants for craniomaxillofacial defects, an in vitro, in vivo, and clinical study

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