Biocompatibility and Osteogenic Potential of New Generation Endodontic Materials Established by Using Primary Osteoblasts

Effects of an Experimental Calcium Aluminosilicate Cement on the Viability of Murine Odontoblast-like Cells

“…Another related calcium aluminosilicate cement (Capasio; Primus Consulting, Bradenton, FL) has been previously evaluated for its physical properties (23) and in vitro bone nodule formation by rat calvarial osteoblasts (24). Capasio is composed primarily of bismuth oxide, dental glass, and calcium aluminosilicate with a waterbased gel.…”

“…The material is slightly less basic (pH = 10.9) than white MTA (pH = 11.6) upon the final setting, has a setting time of 9 minutes, penetrates dentinal tubules, and shows improved acid resistance and washout resistance versus MTA. Recently, Capasio powder has been refined and renamed as Quick-Set (Primus Consulting), and the cationic surfactant was removed from the liquid gel component, which was thought to interfere with cell cytocompatibility (24). The quick setting, fine particles, high radiopacity, and slightly elevated pH properties of Capasio were preserved in Quick-Set.…”

Material Modifications and Related Materials

“…However, Generex A is mixed with unique gels instead of water and, together with a powder consistency, results in improved material handling and shorter setting time. Generex A powders contain hydroxyapatite to nucleate the production of hydroxyapatite in vivo which might be responsible for acceleration of osteoblastic activity in rats [ 170 ]. In addition, in an in vitro study, its compressive strength, washout resistance, and setting time were found to be better than MTA [ 139 ].…”

Products and Distinctions

“…In 2005-2010, experimental products from Dentsply were described in the literature: ProRoot MTA Advanced [79,97] and ProRoot MTA sealer (AKA Generex A and B, respectively). The former had the usual periapical and pulpal contact indications; the latter was indicated only for root canal sealing.…”

“…The Quick-Set system includes a fine calcium aluminosilicate powder and a water-based gel. This material is quick-setting, washout resistant, and acid resistant [97]. QuickSet is chemically distinct from MTA because it does not contain tri-or dicalcium silicate.…”