Biocompatibility evaluation of pH and glutathione-responsive nanohydrogels after intravenous administration

Pérez, Elena; Olmo, Rosa; Teijón, César; Muñiz, E; Montero, Nuria; Teijón, José M.; Blanco, Marcos

doi:10.1016/j.colsurfb.2015.09.017

Cited by 16 publications

(7 citation statements)

References 43 publications

(73 reference statements)

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“…MBAm functioned as an ideal candidate due to its affordablility, commercial availability, and biocompatibility. [44] MBAm commonly finds application as a cross‐linker in acrylamide‐based hydrogels. [45] Previous success with MBAm‐containing poly(β‐thioester) segmented block copolymers further recommended MBAm as an ideal comonomer.…”

Section: Resultsmentioning

confidence: 99%

Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold

Moon

Mazzini

Pekkanen

et al. 2018

Macro Chemistry & Physics

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The monomer isosorbide diacrylate (iSDA) and commercially available dithiols allowed access to a range of biosourced, degradable polymers. Altering the dithiol identity significantly affected the glass transition Tgs of the polymer products; however, polymers did not exhibit Tgs above room temperature. Incorporating the comonomer N,N′‐methylene bisacrylamide provided mechanical reinforcement through hydrogen bonding, resulting in soft, pliable materials. Differential scannin calorimetry (DSC) and variable‐temperature fourier‐transform infrared (FTIR) spectroscopy indicated that increases in mechanical integrity resulted from hydrogen bonding. Dynamic mechanical analysis (DMA) revealed materials that exhibited suitable moduli and service windows at body temperature. Biological evaluation demonstrated favorable cytotoxicity and cell attachment, rendering these materials potential candidates as novel scaffold materials for tissue growth.

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Section: Resultsmentioning

confidence: 99%

Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold

Moon

Mazzini

Pekkanen

et al. 2018

Macro Chemistry & Physics

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“…Biochemical stimuli-responsive nanohydrogels hold great promise in creating targeted and responsive drug delivery systems, enabling precise control over drug release at specific sites in the body. [24] Additionally, they have potential applications in tissue engineering, diagnostics, and other biomedical fields where controlled responses to biochemical cues are essential. Some common examples of such stimuli responsive nanohydrogels based on biochemical stimuli:…”

Section: Biochemical Stimuli Responsementioning

confidence: 99%

“…Nanohydrogel response to surrounding environment. [23][24][25][26] Figure 3. Binding process of Hybrid nanohydrogel.…”

Section: Challenges To Practical Applications and Commercialization O...mentioning

confidence: 99%

Exploring Nanohydrogels: Crafting Innovations for Biomedical Advancements

Sharma,

Ghosh,

Sengupta

et al. 2024

ChemistrySelect

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Here in, we discuss different types of nanohydrogels in the field of biomedicine, highlighting their unique properties such as size, biocompatibility, and tuneable drug release capabilities. Nanohydrogels are considered versatile tools for applications in tissue engineering, drug delivery, and diagnostics, with the ability to target specific sites and release therapeutic agents in a controlled manner. The controlled‐release characteristics of nanohydrogels are particularly emphasized for targeted drug delivery, potentially transforming therapies for conditions like cancer by maximizing treatment efficacy while minimizing damage to healthy tissues. Several research articles published on nanohydrogels has been steadily increasing over the years, indicating growing interest and research activity in this field. This review provides an overview of contemporary methodologies employed in nanohydrogel design, their utilization in biomedical contexts, and their pivotal role in shaping advanced therapeutics. Recent investigations on nanohydrogels are scrutinized for their extensive utility in devising strategies conducive to finely tuned biological applications. Challenges and obstacles associated with the nanohydrogel technology in biomedicine also has been discussed. Cautious handling of the interaction of nanohydrogels with complex biological systems is also emphasized for the successful integration of this technology into medical applications.

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“…Reduction-sensitive systems can also be adopted in nanocarriers, such as cationic polyamidoamine dendrimers, dendrimer-encapsulated gold nanoparticles, 36 disulfide crosslink nanogels, 37 liposomes, 38 capped mesoporous nanoparticles, 39 etc. For liposome-based systems, they usually have two forms of disulfide-conjugated lipids on their surface.…”

Section: Reduction-responsive Systemsmentioning

confidence: 99%

Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

2016

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Huachao Chen received her M.Sc. degree in chemistry from Shandong Normal University in 2011. After receiving her Ph.D. degree from the Nanjing University in 2015, she is now a lecturer at the China Pharmaceutical University. Her research interests include the multifunctional "stimulus-responsive" drug delivery system, antitumor plant cyclopeptides, and fluorescent imaging of bioactive substance.Danyang Liu received her B.S. degree in chemistry from Nanjing University in 2015. Then she joined Prof. Guo's group at Nanjing University to pursue her M.Sc. degree in bioinorganic chemistry. Her recent research focus on nanoparticle-based antitumor drug delivery. CL-151176Received AbstractDrug release in a spatially and temporally controlled manner is highly desired in the field of drug delivery. Endogenous stimuliresponsive nanocarriers provide significant advantages in maximizing the therapeutic efficacy and minimizing the side effects of loaded drugs. Biomarker-triggered release and site-specific delivery are the most commonly adopted strategies. In this review, the most recent advances in the field of endogenous stimuli-responsive drug delivery nanocarriers and their potential application in the treatment of various diseases are highlighted and discussed.

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Biocompatibility evaluation of pH and glutathione-responsive nanohydrogels after intravenous administration

Cited by 16 publications

References 43 publications

Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold

Sugar‐Derived Poly(β‐thioester)s as a Biomedical Scaffold

Exploring Nanohydrogels: Crafting Innovations for Biomedical Advancements

Endogenous Stimuli-responsive Nanocarriers for Drug Delivery

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