Biocompatibility of a new pulp capping cement

Abstract

SummaryAim. The aim of the present study was to evaluate the biocompatibility of a new pulp capping material (Biodentine, Septodont) compared with reference pulp capping materials: Dycal (Dentsply), ProRoot MTA (Dentsply) and MTA-Angelus (Angelus) by using murine odontoblast cell line and Alamar blue and MTT cytotoxicity tests. Methods. The citocompatibility of murine odontoblasts cells (MDPC-23) were evaluated at different times using a 24 Transwell culture plate by Alamar blue test and MTT assay. Results. The results were significantly different among the pulp capping materials tested. Biocompatibility was significant different among materials with different composition. Conclusions. Biodentine and MTA-based products show lower cytotoxicity varying from calcium hydroxide-based material which present higher citotoxicity.

Expression of Mineralization Markers during Pulp Response to Biodentine and Mineral Trioxide Aggregate

“…Studies comparing the cell viability of Biodentine and MTA have shown the similarity between the 2 materials (23)(24)(25)(26)(27). Those results are in agreement with the findings of this study, which showed that Biodentine and MTA had a similar effect on cell viability.…”

Antimicrobial and antibiofilm activities of MTA supplemented with bismuth lipophilic nanoparticles

“…This result is consistent with the early report of Poggio et al who described lack of cytotoxicity in MTA and biodentine 37) . Interestingly, MTA-BisBAL NPs seems to attract to HGF in comparison with MTA alone may be due to lipophilicity of BisBAL nanoparticles.…”

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

“…Once internalized, nanomaterials may cause a broad range of biological effects such as inflammatory responses, oxidative stress, DNA damage and apoptosis (Huang et al, 2013;Kodali et al, 2013;Sahu et al, 2013;Song et al, 2009;Stebounova et al, 2011;Steuer et al, 2014;Stoccoro et al, 2013;Ucciferri et al, 2014). Silica nanoparticles, for instance, have been shown to induce reactive oxygen species autophagy in human hepatocytes (Mohammadi et al, 2014;Poggio et al, 2014), neurotoxicity and Alzheimer-like pathology in human and mouse neuronal cells (Yang et al, 2014), spermatogenesis damage (Xu et al, 2014) and impairment of vascular homeostasis (Nemmar et al, 2014).…”