Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Tedesco, Erik; Mičetić, Ivan; Ciappellano, Silvia Gabriella; Micheletti, Christian; Venturini, M.; Benetti, Federico

doi:10.1016/j.tiv.2015.07.002

Cited by 11 publications

(5 citation statements)

References 55 publications

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“…While the ZnO and SiO 2 nanoparticles exhibited statistically significant high-toxicity towards the A549 human lung cells, no statistically significant cytotoxic effect was observed for the coated SiO 2 (–methyl, –octyl) and TiO 2 nanoparticles, even up to their highest tested concentration of 250 μg L −1 (Figure 3). These results agreed favorably with the literature [21].…”

Section: Resultssupporting

confidence: 93%

Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

et al. 2019

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Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. In this study, we compare the toxicological effects of pristine TiO2, ZnO, SiO2, and coated SiO2 nanoparticles, and evaluate their suitability as additives to consolidants of weathered construction materials. First, water soluble tetrazolium 1 (WST-1) and lactate dehydrogenase (LDH) assays were used to determine the viability of human alveolar A549 cells at various nanoparticle concentrations (0–250 μg mL−1). While the pristine TiO2 and coated SiO2 nanoparticles did not exhibit any cytotoxic effects up to the highest tested concentration, the pristine SiO2 and ZnO nanoparticles significantly reduced cell viability. Second, as all developed nanoparticle-modified consolidants increased the mechanical strength of weathered sandstone, the decisive criterion for the selection of the most suitable nanoparticle additive was as low toxicity as possible. We believe that this approach would be of high importance in the industry, to identify materials representing top functional properties and low toxicity, at an early stage of the product development.

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Section: Resultssupporting

confidence: 93%

Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

et al. 2019

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“…nanoparticles, up to their highest tested concentration of 250 μg L −1 (Figure 3). These results are in good agreement with the literature [21].…”

Section: Evaluation Of the Nanoparticles Cytotoxicitysupporting

confidence: 93%

Toxicity of TiO<sub>2</sub>, ZnO and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-By-Design Development of Construction Materials

Remzova¹,

Žouželka²,

Brzicova³

et al. 2019

Preprint

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Rapid progress in the development of highly efficient nanoparticle-based construction technologies has not always been accompanied by a corresponding understanding of their effects on human health and ecosystems. Here, we compare toxicological effects of pristine TiO2, ZnO and SiO2, and coated SiO2 nanoparticles and evaluate their suitability as additives to consolidants of weathered construction materials. First, WST-1 and LDH assays were used to determine the viability of human alveolar A549 cells at various nanoparticle concentrations (0–250 μg mL−1). While the pristine TiO2 and coated SiO2 nanoparticles did not exhibit any cytotoxic effect up to the highest tested concentration, the pristine SiO2 and ZnO nanoparticles significantly reduced cell viability. Second, as all the developed nanoparticle-modified consolidants increased the mechanical strength of weathered sandstone, the decisive criterion for the selection of the most suitable nanoparticle additive was as low toxicity as possible. We believe that this approach will be of high importance for industry to identify materials representing top functional properties and low toxicity at an early stage of the product development.

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“…For example, commercial products for restauration of minerals are based on dispersions of calcium hydroxide particles of several hundreds of nm in size in ethanol. [43,44] It is easy to see that these conventional mineralization solutions based on (solid) particles are limited in their infiltration efficiency as soon as the dimensions of the template reach the dimensions of the particles, while a liquid, or liquid-like, precursor can easily "flow" into fine cracks. If we think of this "molding" of crystalline structures, the possible resolution and details should be much higher using a liquid-like precursor compared to (solid) particle-based approaches, which also will only produce an agglomeration of particles instead of an extended solid mineral structure.…”

Section: Materials Synthesis From Sculpt Liquid-like Mineral Precursormentioning

confidence: 99%

Bottling Liquid‐Like Minerals for Advanced Materials Synthesis

et al. 2023

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Materials synthesis via liquid-like mineral precursors has been studied since their discovery almost 25 years ago, because their properties offer several advantages, for example, the ability to infiltrate small pores, the production of non-equilibrium crystal morphologies or mimicking textures from biominerals, resulting in a vast range of possible applications. However, the potential of liquid-like precursors has never been fully tapped, and they have received limited attention in the materials chemistry community, largely due to the lack of efficient and scalable synthesis protocols. Herein, the "scalable controlled synthesis and utilization of liquid-like precursors for technological applications" (SCULPT) method is presented, allowing the isolation of the precursor phase on a gram scale, and its advantage in the synthesis of crystalline calcium carbonate materials and respective applications is demonstrated. The effects of different organic and inorganic additives, such as magnesium ions and concrete superplasticizers, on the stability of the precursor are investigated and allow optimizing the process for specific demands. The presented method is easily scalable and therefore allows synthesizing and utilizing the precursor on large scales. Thus, it can be employed for mineral formation during restoration and conservation applications but can also open up pathways toward calcium carbonate-based, CO 2 -neutral cements.

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Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Cited by 11 publications

References 55 publications

Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

Toxicity of TiO<sub>2</sub>, ZnO and SiO<sub>2</sub> Nanoparticles in Human Lung Cells: Safe-By-Design Development of Construction Materials

Bottling Liquid‐Like Minerals for Advanced Materials Synthesis

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