Biocompatibility of a quad-shank neural probe

Tyson, Joel; Tran, Minhquan; Slaughter, Gymama

doi:10.1016/j.sse.2017.06.019

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Although polymeric modified biosensors detect NTs, CPs are somewhat limited due to their low sensitivity and reliability because of the poor electron transfer between the target molecule and the current collector [16]. Carbon based materials, such as graphene, carbon nanotubes (CNTs), and carbon black activated carbon are widely used in the fabrication of electrochemical transducers due to their good physical and chemical properties, high conductivity, relative inertness, wide voltage range, and fast heterogeneous electron transfer [17,18]. For example, carbon microelectrodes have been used to directly detect and monitor the fast changes in monoamine neurotransmitters, such as dopamine.…”

Section: Biosensing Of Neurotransmittersmentioning

confidence: 99%

“…They both possess a unique combination of properties including electrical, magnetic, optical, mechanical, and chemical properties, all of which offer great promise for a wide range of applications. In addition, they provide a large active surface area and an electrocatalytic activity that are advantageous in the development of electrochemical transducers [17,21,22]. Several CNTs and graphene-based NT sensors have been reported [23][24][25] with enhanced catalytic activity, wherein metallic nanoparticles (NPs) are anchored to both graphene and CNT substrate to provide excellent electron mediation for electron transfer between nanoparticles and substrate.…”

Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

“…To enhance the sensitivity, selectivity, and stability of the CV technique for sensing NTs, CNTs have been explored as sensing materials for electrochemical biosensors [17]. CNTs have been demonstrated to promote electron transfer, electrocatalysis and electroanalysis processes because of their considerable mechanical strength, high electrical conductivity, high surface area, good chemical stability, and relative chemical inertness in most electrolyte solutions.…”

Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

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Electrochemical Detection of Neurotransmitters

et al. 2020

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Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the complex intercommunication of neurotransmitters. Therefore, it is crucial to develop clinical assessment techniques that are sensitive and reliable to monitor and modulate these chemical messengers and screen diseases. This review focuses on summarizing the current electrochemical measurement techniques that are capable of sensing neurotransmitters with high temporal resolution in real time. Advanced neurotransmitter sensing platforms that integrate nanomaterials and biorecognition elements are explored.

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Section: Biosensing Of Neurotransmittersmentioning

confidence: 99%

Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

Section: Neurosensing Via Cyclic Voltammetrymentioning

confidence: 99%

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Electrochemical Detection of Neurotransmitters

et al. 2020

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“…Polymers such as polyimide and polyethylene terephthalate are commonly used in biosensor and implantable devices due to their high flexibility, electrical resistivity, thermal and chemical stability, and biocompatibility. 31,[36][37][38][39][40] We selected platinum (Pt) for the temperature sensor due to its high linear correlation between electrical resistance and temperature (Fig. 3a).…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Periodontal Probes and Their Handheld Electronic System for Simultaneous Temperature, pH, and Depth Measurements

Ritzert¹,

Rani²,

Ko³

et al. 2022

J. Electrochem. Soc.

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Microscale temperature and pH sensors, contained within an area of 125 × 750 μm, were fabricated on disposable 3D printed periodontal probe tips (0.5 mm diam) with Marquis color-coded calibration marks using microfabrication and electrochemical methods. The probe tips were inserted in a reusable, wireless handheld electronic system that records the temperature and pH of specific oral sites such as a gingival sulcus. The linear response and precision of each sensor were tested in solutions of varying temperature and pH representing the physiological range of the oral cavity. The temperature and pH sensors showed linear response from 25 to 60°C (±0.1°C) and pH 4.0 to pH 8.0 (±0.1), respectively. A calibration function performed by the system software increased precision between probes tenfold for temperature sensors (deviation range: 0.69 to –0.07°C) and twofold for pH sensors (deviation range: 0.07 to 0.04). Wireless communication along with compatible software provides portability and facilitates chairside use. Simultaneous measurement of temperature and pH along with gingival sulcus depth may detect early signs of inflammation that current methods, such as probing and radiography, may not identify, thus minimizing potential tissue damage caused by periodontal disease.

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“…Many types of commercially available polyimides have been widely used for biosensor encapsulation and as substrates for implantable devices due to their high flexibility, electrical resistivity, thermal and chemical stability, and biocompatibility [24][25][26]. In addition to these benefits, photo-definable polyimides are easy to pattern using photo-lithography, which facilitates biosensor or bioelectronics fabrication [25][26][27][28]. Therefore, in this study, photo-definable polyimide (HD-8820, HD MicroSystems, Parlin, NJ, USA) served as both structural substrates and insulation layers that resulted in simplified fabrication and cost savings.…”

Section: Sensor Materials and Designmentioning

confidence: 99%

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

Kim

Stafford

Beauchamp

et al. 2020

Sensors

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Implantable sensors capable of real-time measurements are powerful tools to diagnose disease and maintain health by providing continuous or regular biometric monitoring. In this paper, we present a dental implantable temperature sensor that can send early warning signals in real time before the implant fails. Using a microfabrication process on a flexible polyimide film, we successfully fabricated a multi-channel temperature sensor that can be wrapped around a dental implant abutment wing. In addition, the feasibility, durability, and implantability of the sensor were investigated. First, high linearity and repeatability between electrical resistance and temperature confirmed the feasibility of the sensor with a temperature coefficient of resistance (TCR) value of 3.33 × 10–3/°C between 20 and 100 °C. Second, constant TCR values and robust optical images without damage validated sufficient thermal, chemical, and mechanical durability in the sensor’s performance and structures. Lastly, the elastic response of the sensor’s flexible substrate film to thermal and humidity variations, simulating in the oral environment, suggested its successful long-term implantability. Based on these findings, we have successfully developed a polymer-based flexible temperature sensor for dental implant systems.

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Biocompatibility of a quad-shank neural probe

Cited by 6 publications

References 15 publications

Electrochemical Detection of Neurotransmitters

Electrochemical Detection of Neurotransmitters

Multifunctional Periodontal Probes and Their Handheld Electronic System for Simultaneous Temperature, pH, and Depth Measurements

Development of a Dental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious Disease

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