Biocompatibility of cardiopulmonary bypass circuit with new polymer Senko E-Ternal Coating^TM

Abstract

The SEC-coated circuit demonstrated equivalent biocompatibility to the PMEA-coated circuit. SEC-coated circuits are, therefore, favorably comparable to PMEA-coated circuits for clinical use in CPB.

Clinical application of a new ternary polymer, SEC-1 coat™, for pediatric cardiopulmonary bypass circuits: a prospective randomized pilot study

“…The three polymers comprising SEC are (1) a long-chain alkyl group that enhances the affinity between the coating and the base materials and improves durability; (2) a water-repellent silicone polymer based on dimethylpolysiloxane that regulates complement activation; and (3) a highly hydrophilic polyethylene glycol chain that regulates the activation and cascade reaction of the coagulation system by suppressing the adhesion or adsorption of platelets and plasma proteins. Fukui et al 2 compared the biocompatibility of SEC-coated and poly-2-methoxyethyl acrylate (PMEA)-coated circuits, the latter being a material used commonly for CPB circuits. They demonstrated that the SEC-coated circuit has biocompatibility equivalent to that of the PMEA-coated circuit, with no significant differences in coagulation or inflamma-tion during CPB.…”

“…However, drawbacks include heparin-related bleeding, heparin-induced thrombocytopenia, and contamination of heparin from the porcine intestine from which it is usually extracted. 2,3 SEC-1 coat™ (SEC; TOYOBO Co., Ltd, Osaka, Japan) is a commercially available coating material designed to improve the biocompatibility of CPB circuit surfaces in contact with blood. Fukui et al 2 demonstrated in adults that SEC-coated CPB circuits have excellent biocompatibility with regard to minimizing coagulation and inflammation during aortic valve replacement surgery.…”

“…2,3 SEC-1 coat™ (SEC; TOYOBO Co., Ltd, Osaka, Japan) is a commercially available coating material designed to improve the biocompatibility of CPB circuit surfaces in contact with blood. Fukui et al 2 demonstrated in adults that SEC-coated CPB circuits have excellent biocompatibility with regard to minimizing coagulation and inflammation during aortic valve replacement surgery. However, to the best of our knowledge, no study has reported the use of SEC-coated circuits for pediatric CPB.…”

Strategies for blood conservation in pediatric cardiac surgery

“…Heparin, trillium, poly-2-methoxyehylacrylate, phosphorylcholine, and senko e-ternal coating has been used till date. [ 63 64 65 66 67 68 69 70 ] The purpose of modifying the surface of extracorporeal circuit is to prevent the inflammatory response that occurs during CPB. Therefore, the majority of studies done on surface modified circuits have evaluated the rise and fall in the serum levels of inflammatory cytokines and molecules.…”

Hemodialysis Membrane Coated with a Polymer Having a Hydrophilic Blood-Contacting Layer can Enhance Diffusional Performance

“…This biocompatible polymer coating agent (BPA) is composed of a hydrophobic backbone adherent to the surface, and a hydrophilic blood-contacting layer. The hydrophilic layer swells when blood contacts it, creating a water-filled layer that maintains protein conformation and prevents surface activation ( 10 ), and many studies have reported a reduction in the circuit's thrombogenecity, or reduction in the heparin dose needed to achieve adequate anticoagulation by BPA coating ( 11 – 15 ). In our previous study, a hemoconcentrator, which has similar function as the hemodialyzer in cardiopulmonary bypass circuit, was probatively coated with BPA and investigated as regards hydrokinetics.…”