Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

Naahidi, Sheva; Jafari, Mousa; Logan, Megan; Wang, Yujie; Yuan, Yongfang; Bae, Hojae; Dixon, Brian; Chen, P.

doi:10.1016/j.biotechadv.2017.05.006

Cited by 696 publications

(436 citation statements)

References 297 publications

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“…Hydrogele eignen sich durch ihre Biokompatibilität sowie antiinflammatorischen und nichtimmunogenen Eigenschaften hervorragend als Biomaterial in biomedizinischen Anwendungen oder im Tissue Engineering [4,7,12,19]. Um ein HA-Gel zu erhalten, müssen die HA-Moleküle zunächst chemisch modifiziert werden (z.…”

Section: » Hyaluronsäure Ist Ein Körpereigenes Polysaccharidunclassified

Hyaluronsäuregele zur Druckregulierung in der Glaukomtherapie

et al. 2017

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Section: » Hyaluronsäure Ist Ein Körpereigenes Polysaccharidunclassified

Hyaluronsäuregele zur Druckregulierung in der Glaukomtherapie

et al. 2017

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“…Wearable or implantable devices are in direct contact with the human body and are expected not to cause damage to human health . Due to the unique hydrated environment and adjustable physicochemical properties, CPHs as a good candidate of biocompatible material have been widely used in a large number of biological devices such as biosensor, tissue engineering, controlled drug delivery, and cell culture …”

Section: Properties Of Cphsmentioning

confidence: 99%

Properties of conductive polymer hydrogels and their application in sensors

Guo

Pan

et al. 2019

J Polym Sci B Polym Phys

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Conductive polymer hydrogels (CPHs), which combine the unique advantages of hydrogels and organic conductors, have received wide attention due to their adjustable mechanical properties, biocompatibility, self‐healing, hydrophilicity, and ease of preparation. With doping engineering and incorporation with other functional nanomaterials, CPHs have exhibited excellent physical/chemical properties. CPHs have been widely used in various electronic devices, especially in the field of sensors due to its sensitivity to external stimuli. This review summarizes recent progress in CPHs from the aspect of the CPHs' properties and their application in advanced sensor technology. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1606–1621

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“…These can be engineered for specific composition, rigidity and pore size to try and mimic the architecture and properties for the target tissue, and combined and cross-linked with growth factors, ECM components, nanoparticles and many other molecules to enhance cellular responses: such complexes represent a major area of research for bioengineering. 48 One use is for cell sheet engineering, where temperature-responsive culture dishes allows harvesting of cells (without trypsin) on intact polymer sheets and progressive layering of sheets with different types of cells can build up various tissues, including the use of endothelial vascular cells to construct vascularised tissues. There is much interest in strategies to improve the blood supply in order to form thick implantable viable tissue constructs, with much research focussed on strategies to enhance vascularisation of muscle tissues.…”

Section: Scaffolds: New Materials Revascularisation Biomechanics mentioning

confidence: 99%

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Grounds

2018

Clin Exp Pharma Physio

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The clinical need and historical approaches to tissue engineering as applied to regenerative medicine are introduced, along with comments on activities in this field around Australia, and then the huge advances for tissue culture studies are discussed (Part A). Combinations of human stem cells and new approaches for generating bioscaffolds present great opportunities for in vitro studies of basic biology and physiology, drug testing and high throughput screening for the pharmaceutical industry, and the advanced tissue engineering of organs and devices. The future here is bright. The major obstacles arise with in vivo application of these bioengineering advances using animal models and humans (Part B), and the complexity of living tissues and the challenges of increased scale required for clinical translation to the large human situation are first discussed. While clinical success seen with implantation of acellular bioscaffolds (with population by host cells) is likely to expand for human use, the major challenge relates to (generally) low survival in vivo of (donor or autologous) cells that are expanded and grown in tissue culture before implantation into the living body. Another major challenge is revascularisation of implanted tissues/organs at the human scale. The innovative approaches and rapid advances in tissue bioengineering hold great promise for overcoming these major obstacles and extending the clinical applications of these technologies.

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Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

Cited by 696 publications

References 297 publications

Hyaluronsäuregele zur Druckregulierung in der Glaukomtherapie

Hyaluronsäuregele zur Druckregulierung in der Glaukomtherapie

Properties of conductive polymer hydrogels and their application in sensors

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

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