Biocompatibility of materials and its relevance to drug delivery and tissue engineering

Chandy, Thomas

doi:10.1016/b978-0-08-102680-9.00012-3

Cited by 14 publications

(15 citation statements)

References 141 publications

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“…Implantable biomaterials with the capability of providing both an appropriate scaffold for tissue engineering and controlled localized drug delivery have opened new horizons in tissue engineering and regenerative medicine. Such biomaterials are capable of direct cell differentiation through high-performance localized delivery of therapeutic agents and drugs, which have adverse effects or limited effects through systemic drug administration methods, such as oral and intravenous administration. − Drug delivery systems (DDSs) that deliver a therapeutic agent upon a specific stimulus are called triggered DDS. If designed properly, a triggered DDS can deliver a drug directly at the point of care at the desired point in time to achieve a localized high concentration of drug while minimizing overall injected dose and systemic concentrations.…”

Section: Introductionmentioning

confidence: 99%

On-Demand Reversible UV-Triggered Interpenetrating Polymer Network-Based Drug Delivery System Using the Spiropyran–Merocyanine Hydrophobicity Switch

Ghani¹,

Heiskanen²,

Kajtez³

et al. 2021

ACS Appl. Mater. Interfaces

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Section: Introductionmentioning

confidence: 99%

On-Demand Reversible UV-Triggered Interpenetrating Polymer Network-Based Drug Delivery System Using the Spiropyran–Merocyanine Hydrophobicity Switch

Ghani¹,

Heiskanen²,

Kajtez³

et al. 2021

ACS Appl. Mater. Interfaces

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“…The studies so far showed the potential of the designed cellulose peptide hybrid hydrogel as a suitable biomaterial for cell culture; however, for its biomedical application, it is essential to study if any immune response can be elicited by the hydrogels. 4 Earlier reports have shown that based on the physicochemical properties of the biomaterials, they can induce various foreign body responses in the host tissue. 85 However, the extremity of these immune responses can be controlled by tuning the surface chemistry and physical properties of the biomaterial.…”

Section: Hydrophobicity Analysis Of the Nfc−bioactive Peptide Composi...mentioning

confidence: 99%

“…3 Hence, it is desirable to design a hydrogel that not only mimics the structural and functional attributes of native ECM but also displays a nontoxic and nonimmunogenic response. 4 efforts were focused on utilizing biocompatible natural building blocks for fabricating supramolecular hydrogels. 3 In this direction, peptide-based hydrogels have gained a significant leap owing to their similarity with the native ECM in terms of continuous network formation, high water content, tissue-like 3D structure, tunable mechanical stiffness matching different tissues, diverse functionality, and compatibility to the biological framework.…”

Section: Introductionmentioning

confidence: 99%

Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold

Kaur¹,

Sharma²,

Pal³

et al. 2023

ACS Biomater. Sci. Eng.

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It has been increasingly evident over the last few years that bioactive peptide hydrogels in conjugation with polymer hydrogels are emerging as a new class of supramolecular materials suitable for various biomedical applications owing to their specificity, tunability, and nontoxicity toward the biological system. Despite their unique biocompatible features, both polymer- and peptide-based scaffolds suffer from certain limitations, which restrict their use toward developing efficient matrices for controlling cellular behavior. The peptide hydrogels usually form soft matrices with low mechanical strength, whereas most of the polymer hydrogels lack biofunctionality. In this direction, combining polymers with peptides to develop a conjugate hydrogel can be explored as an emergent approach to overcome the limitations of the individual components. The polymer will provide high mechanical strength, whereas the biofunctionality of the material can be induced by the bioactive peptide sequence. In this study, we utilized TEMPO-oxidized nanofibrillar cellulose as the polymer counterpart, which was co-assembled with a short N-cadherin mimetic bioactive peptide sequence, Nap-HAVDI, to fabricate an NFC–peptide conjugate hydrogel. Interestingly, the mechanical strength of the peptide hydrogel was found to be significantly improved by combining the peptide with the NFC in the conjugate hydrogel. The addition of the peptide into the NFC also reduced the pore size within NFC matrices, which further helped in improving cellular adhesion, survival, and proliferation. Furthermore, the cells grown on the NFC and NFC–peptide hybrid hydrogel demonstrated normal expression of cytoskeleton proteins, i.e., β-tubulin in C6 cells and actin in L929 cells, respectively. The selective response of neuronal cells toward the specific bioactive peptide was further observed through a protein expression study. Thus, our study demonstrated the collective role of the cellulose–peptide composite material that revealed superior physical properties and biological response of this composite scaffold, which may open up a new platform for biomedical applications.

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“…On foreign surfaces, on the other hand, platelet activation mainly takes place through platelet adhesion due to adsorbed plasma proteins. Foreign surface-induced platelet adhesion and activation is initiated by surface-adsorbed proteins, such as von Willebrand factor (vWf), and fibrinogen, but also fibronectin, and vitronectin [ 102 , 103 , 104 ]. A simplified scheme of platelet interactions in contact with biomaterials and subsequent thrombus formation is depicted in Figure 1 B.…”

Section: Coagulation Platelet and Complement Activation On Foreign Materialsmentioning

confidence: 99%

Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

et al. 2021

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Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side effects, such as an increased bleeding risk, make materials that have a better hemocompatibility highly desirable, particularly in long-term applications. This review provides a short overview on the basic mechanisms of blood coagulation including plasmatic coagulation and blood platelets, as well as the activation of the complement system. Furthermore, a survey on concepts for tailoring the blood response of biomaterials to improve the hemocompatibility of medical devices is given which covers different approaches that either inhibit interaction of material surfaces with blood components completely or control the response of the coagulation system, blood platelets and leukocytes.

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Biocompatibility of materials and its relevance to drug delivery and tissue engineering

Cited by 14 publications

References 141 publications

On-Demand Reversible UV-Triggered Interpenetrating Polymer Network-Based Drug Delivery System Using the Spiropyran–Merocyanine Hydrophobicity Switch

On-Demand Reversible UV-Triggered Interpenetrating Polymer Network-Based Drug Delivery System Using the Spiropyran–Merocyanine Hydrophobicity Switch

Exploring Supramolecular Interactions between the Extracellular-Matrix-Derived Minimalist Bioactive Peptide and Nanofibrillar Cellulose for the Development of an Advanced Biomolecular Scaffold

Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

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