2021
DOI: 10.3390/bioengineering8120215
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Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review

Abstract: Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for the short- and long-term applications of medical devices such as cardiovascular stents, artificial heart valves, ventricular assist devices, catheters, blood linings and extracorporeal devices such as artificial kidneys (hemodialysis), extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass. Although lower blood compatibility of materials and devices can be handled with systemic anticoagulation, its side… Show more

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Cited by 54 publications
(29 citation statements)
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References 221 publications
(275 reference statements)
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“…Another factor influencing protein adsorption on hydrophilic surfaces is the type of charge. Negatively charged surfaces typically lead to a lower extent of protein adsorption than positively charged surfaces because many proteins have a net negative charge at physiological pH values [51]. These reports correspond with the fact that the presence of sulfate groups in furcellaran and κ-carrageenan might be attributed to the change in the negative charge density and influence its interactions with the coagulation proteins.…”
Section: Anticoagulant Activity Assessmentmentioning
confidence: 81%
See 1 more Smart Citation
“…Another factor influencing protein adsorption on hydrophilic surfaces is the type of charge. Negatively charged surfaces typically lead to a lower extent of protein adsorption than positively charged surfaces because many proteins have a net negative charge at physiological pH values [51]. These reports correspond with the fact that the presence of sulfate groups in furcellaran and κ-carrageenan might be attributed to the change in the negative charge density and influence its interactions with the coagulation proteins.…”
Section: Anticoagulant Activity Assessmentmentioning
confidence: 81%
“…It is worth noting that none of the samples extended beyond anticoagulation action. In many cases, the prolongation of clotting time is dose-dependent [51,52]. With respect to the abovementioned, a slight anticoagulant effect was observed in the case of sample PET_DC_KAPA.…”
Section: Anticoagulant Activity Assessmentmentioning
confidence: 90%
“…Moreover, the favorable interaction between a material and the blood tissue is strongly contingent on composition, internal morphology, porosity, surface roughness and chemistry etc. [ 44 , 45 , 46 , 47 ].…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, implantation procedure would not change considerably. Additionally, use of bio- and hemocompatible materials such as titanium alloy, cobalt–chromium–molybdenum alloy and DLC ensures suitability for clinical use [ 54 ]. Furthermore, in the case of Sputnik 1, manufacturing of a diffuser is the most technologically difficult process due to complex geometry, which leads to high risk of defects, and hence, raises the overall cost of LVAD.…”
Section: Discussionmentioning
confidence: 99%