Biocompatibility of Mineral Trioxide Aggregate 
with TiO2 Nanoparticles on Human Gingival Fibroblasts

Samiei, Mohammad; Ghasemi, Negin; Aghazadeh, Mohammad; Divband, Baharak; Akbarzadeh, Farzaneh

doi:10.4317/jced.53126

Cited by 15 publications

(19 citation statements)

References 24 publications

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“…However, it should be pointed out that during vital pulp therapy, perforation repair and retrograde filling, the cytotoxicity of the material used might influence the viability of dental or periradicular cells, resulting in cell death by apoptosis or necrosis (Samiei et al . ). Therefore, it is important to avoid dental materials that are toxic to pulpal and periodontal cells (Rodriguez‐Lozano et al .…”

Section: Introductionmentioning

confidence: 97%

Comparative analysis of the biological effects of the endodontic bioactive cements MTA‐Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells

et al. 2017

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Section: Introductionmentioning

confidence: 97%

Comparative analysis of the biological effects of the endodontic bioactive cements MTA‐Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells

et al. 2017

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“…tiempo, respecto al control de células sin inocular. Sin embargo, una de las deficiencias que impiden la reproducibilidad de este estudio, es que no se especifica el tamaño de partícula ni el método de obtención de las nanopartículas (51). Al realizar los ensayos de viabilidad celular, una consideración importante es que el método del MTT o incluso el WST-1 pueden dar resultados erróneos.…”

Section: Citotoxicidad De Las Nps De Tio 2 En Cultivo De Células Oralesunclassified

Biocompatibilidad y toxicidad de nanopartículas de dióxido de titanio en la cavidad oral: Revisión sistemática

Argueta-Figueroa

Torres-Gómez²,

Scougall‐Vilchis

et al. 2018

Invest Clin

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The aim of the present review article was to analyze the biological impact and toxicology of titanium dioxide nanoparticles (TiO 2 NPs) to determine their cytotoxicity, reactive oxygen species production as well as induction of oxidative stress through a systematic review of the literature published so far about the biocompatibility of TiO 2 NPs in contact with oral cells. Available data on nanoparticles (NPs) were collected from the PubMed and Science Direct electronic databases, and other sources according to PRISMA recommendations for systematic reviews. In the qualitative analysis of published data on cytotoxicity in oral cells, a slight increase in the number of metabolically active cells has been observed when the TiO 2 NPs are in contact with oral cells; however, at certain doses cellular viability decreases significantly. One of the negative effects of NPs is the induction of prostaglandin E 2 production in a previous pro-inflammatory state, which could increase the existing inflammatory effect. Therefore, the biological application of these nanoparticles must be performed both in vivo and metabolomic studies, since it is possible that the results of the in vitro experiments cannot be extrapolated to an in vivo system, since it been observed that the particles tend to aggregated among them, in the culture medium, used for such as tests. Therefore, although it can be considered a material with light or even biocompatible cytotoxicity, it must not be considered completely harmless.

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“…The introduction of mineral trioxide aggregate (MTA) in endodontics has satisfied most of the ideal properties of root-end filling material. [1][2][3] However, its limitations, such as long setting time and limited antibacterial activity have urged attempts to introduce newer substitutes and formulations. 2 Metallic nanoparticles incorporated into dental materials have shown to improve the physicochemical, mechanical, and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cytotoxic Evaluation of Mineral Trioxide Aggregate with Silver and Titanium Dioxide Nanoparticles

Dsouza¹,

Dsouza²,

Radhakrishna³

et al. 2019

World Journal of Dentistry

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Aim:The aim of the study was to evaluate the cytotoxicity of mineral trioxide aggregate (MTA) when mixed with either silver or titanium dioxide (TiO 2 ) nanoparticles on human lymphocytes. Materials and methods: Human lymphocytes were exposed to white MTA or MTA in combination with silver or TiO 2 nanoparticles. The cytotoxicity was assessed using the MTT assay for freshly mixed pellets, at 24 hours, at 48 hours, and at 72 hours time periods. The results were statistically analyzed. Results: There was no significant difference in the experimental groups with regard to cell viability. The addition of nanoparticles to MTA showed similar cell viability compared with MTA alone. Conclusion: Mineral trioxide aggregate mixed with silver or TiO 2 nanoparticles showed similar biocompatibility to MTA alone. Clinical significance: The cytotoxicity exhibited by silver or TiO 2 nanoparticles when mixed with MTA showed no significant difference and therefore, they can be used as a suitable additive to improve the antimicrobial efficacy of MTA.

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Biocompatibility of Mineral Trioxide Aggregate with TiO2 Nanoparticles on Human Gingival Fibroblasts

Cited by 15 publications

References 24 publications

Comparative analysis of the biological effects of the endodontic bioactive cements MTA‐Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells

Comparative analysis of the biological effects of the endodontic bioactive cements MTA‐Angelus, MTA Repair HP and NeoMTA Plus on human dental pulp stem cells

Biocompatibilidad y toxicidad de nanopartículas de dióxido de titanio en la cavidad oral: Revisión sistemática

In Vitro Cytotoxic Evaluation of Mineral Trioxide Aggregate with Silver and Titanium Dioxide Nanoparticles

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