Biocompatibility of various root canal filling materials <i>ex vivo</i>

Scotti, Roberto; Tiozzo, Roberta; Parisi, Candida; Croce, Maria Antonietta; Baldissara, Paolo

doi:10.1111/j.1365-2591.2008.01403.x

Cited by 15 publications

(17 citation statements)

References 34 publications

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“…In addition, we compared RealSeal core material with gutta-percha because RealSeal core material has similar physical and chemical properties with gutta-percha, and their role and usage in the root canal filling are consistent. As far as we know, gutta-percha is considered to be mildly cytotoxic or even noncytotoxic (11,17). Our results also confirmed that gutta-percha had good biocompatibility.…”

Section: Discussionsupporting

confidence: 93%

“…After evaluating the cell viability by MTT assay, they found that RealSeal core material had better biocompatibility than gutta-percha (12). Although there were numerous experiments (8,10,14,17) showing an acceptable biocompatibility of RealSeal material, when it was compared with gutta-percha, the result was still controversial (19). The cytotoxicity of RealSeal core material could be due to the biodegradable nature of this material (18).…”

Section: Discussionmentioning

confidence: 92%

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Cytotoxicity of RealSeal on Human Osteoblast-like MG63 Cells

Liang

Dong

et al. 2010

Journal of Endodontics

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 92%

Cytotoxicity of RealSeal on Human Osteoblast-like MG63 Cells

Liang

Dong

et al. 2010

Journal of Endodontics

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“…A substitute for gutta-percha cones, RealSeal System (Sybronendo, Sybron Dental Specialties Inc., Orange, CA, USA), uses Resilon cones and RealSeal Sealer (which is basically Resilon). Previous studies showed lower cytotoxicity levels of Resilon-containing sealers when compared with commonly used sealers 13,15 . The fact that Resilon has low setting time in anaerobic environment 10 may account to a better tissue response.…”

Section: Introductionmentioning

confidence: 88%

Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats

et al. 2011

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ObjectiveThis study tested rat connective tissue response to RealSeal, RealSeal primer or AH Plus after 7, 15, 30, 60 and 90 days of implantation.Material and methodsThirty Wistar rats had subcutaneous sockets created on their back and received four implants each of polyethylene tubes containing one of the materials tested according to the groups: AH (AH Plus Sealer); RS (RealSeal Sealer); RP (RealSeal Primer); CG (control group – empty tube). After histological processing, sections were analyzed to identify the presence of neutrophils, lymphocytes and plasma cells, eosinophils, macrophages and giant cells, as well as fibrous capsule and abscesses, by an examiner using light microscope. Kruskal- Wallis and multiple-comparisons test were used for statistical analysis. Significance level was set at 5%.ResultsLymphoplasmacytic infiltrate scores significantly higher than those of the control group were observed at 14 and 60 days in AH group, and at 90 days in RS group (p<0.05). There were no differences in terms of presence of macrophages, giant cells, eosinophils, neutrophils or fibrosis. AH Plus group scored higher for abscesses at 7 days than after any other period (p=0.031). RP group scored higher for lymphoplasmacytic infiltrate at 14 days than at 90 days (p=0.04).ConclusionThe main contribution of this study was to demonstrate that issues involved with tissue tolerance of a Resilon-containing sealer, RealSeal Sealer, cannot be attributed to its primer content.

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“…Gutta-percha is the most common component used in root canal filling materials because it is well tolerated from host tissues [10] but other compounds such as zinc-oxide,eugenol are capable of inducing cytotoxic effects [11-13]. Recently, a new endodontic filling material based on a polyester thermoplastic-filled polymer (Resilon™; Resilon Research LLC, Madison, CT), which looks and performs like gutta-percha, has been developed and put on the market.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies [13] showed satisfactory in vitro biocompatibility of both the new self-etching sealer Real Seal 1™ and Real Seal TM filling materials. The first one showed a mild cytotoxic effect comparable with that of Pulp Canal Sealer (SybronEndo, Orange, CA, USA), a traditional zinc-oxide and eugenol based endodontic sealer currently used in endodontic practice [14].…”

Section: Introductionmentioning

confidence: 99%

In vitro Evaluation of the Cytotoxicity of Different Root Canal Filling

Gambarini

Testarelli²,

Al-Sudani

et al. 2011

TODENTJ

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Objective:Aim of the present study was to evaluate the cytotoxicity of Real Seal 1 compared to other commercially available endodontic filling materials: Real Seal (SybronEndo, Orange, CA, USA) and Thermafil (Tulsa Dental, Tulsa, OK, USA).Material and Methods:Periodontal ligament cells from healthy patients were cultured. The eluate of Real Seal 1TM (RS1), Real Seal (RS) and Thermafil (TF) samples was used for the cells viability tests, both diluted (50%) or undiluted (100%). Incubation of the specimens was performed in culture medium for 24 h, 48 h and 72 h at 37 °C under sterile conditions. The cellular mortality was evaluated by MTT test. Results were statistically analysed and the statistical significance was set at p< 0.05.Results:None of the studied materials showed toxic effects during the period of observation (0 -72 h) when compared to the control group. Only RS induced a very modest increase in cell mortality (about 3% at both concentrations used, during the first 24 hours), when increasing the incubation time, however, only the lower concentration continued to show modest toxicity.Conclusions:Results of the present study showed that all tested materials did not exhibit cytotoxic effects when compared to the control group.

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Biocompatibility of various root canal filling materials ex vivo

Abstract: RealSeal resin filler was nontoxic in this laboratory model. Further investigations are necessary to verify its usefulness in clinical applications.

Cited by 15 publications

References 34 publications

Cytotoxicity of RealSeal on Human Osteoblast-like MG63 Cells

Cytotoxicity of RealSeal on Human Osteoblast-like MG63 Cells

Biocompatibility of RealSeal, its primer and AH Plus implanted in subcutaneous connective tissue of rats

In vitro Evaluation of the Cytotoxicity of Different Root Canal Filling

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