Biocompatibility studies on TiO&lt;inf&gt;2&lt;/inf&gt; coated Ti surface

Sangeetha, S.; Kathyayini, S. Radhika; Raj, P.; Dhivya, P.; Sridharan, M.

doi:10.1109/icanmeet.2013.6609330

Cited by 10 publications

(16 citation statements)

References 14 publications

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“…The TiO 2 and MPA P samples showed a higher increase in cell growth when compared with the other groups. TiO 2 is known to increase the biocompatibility of pristine titanium [41, 42], which may be the reason for the hMSC-GFP behavior. In addition, sulfur-containing functional groups, such as the mercapto group in MPA, can affect the behavior of cells.…”

Section: Resultsmentioning

confidence: 99%

Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

Trino

Bronze‐Uhle

Ramachandran

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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Titanium (Ti) is widely used in biomedical devices due to its recognized biocompatibility. However, implant failures and subsequent clinical side effects are still recurrent. In this context, improvements can be achieved by designing biomaterials where the bulk and the surface of Ti are independently tailored. The conjugation of biomolecules onto the Ti surface can improve its bioactivity, thus accelerating the osteointegration process. Ti was modified with TiO, two different spacers, 3-(4-aminophenyl) propionic acid (APPA) or 3-mercaptopropionic acid (MPA) and dentin matrix protein 1 (DMP1) peptides. X-ray photoelectron spectroscopy analysis revealed the presence of carbon and nitrogen for all samples, indicating a success in the functionalization process. Furthermore, DMP1 peptides showed an improved coverage area for the samples with APPA and MPA spacers. Biological tests indicated that the peptides could modulate cell affinity, proliferation, and differentiation. Enhanced results were observed in the presence of MPA. Moreover, the immobilization of DMP1 peptides through the spacers led to the formation of calcium phosphate minerals with a Ca/P ratio near to that of hydroxyapatite. Corrosion and tribocorrosion results indicated an increased resistance to corrosion and lower mass loss in the functionalized materials, showing that this new type of functional material has attractive properties for biomaterials application.

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Section: Resultsmentioning

confidence: 99%

Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

Trino

Bronze‐Uhle

Ramachandran

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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“…Titanium dioxide is widely used in medical applications due to its excellent biocompatibility and good mechanical strength [ 6 ]. Crystalline TiO 2 occurs in three phases: anatase, rutile, and brookite.…”

Section: Discussionmentioning

confidence: 99%

“…Crystalline TiO 2 occurs in three phases: anatase, rutile, and brookite. Both anatase and rutile have the capability to form bioactive hydroxyl apatite layers in vitro and have good biocompatibility [ 6 ]. As a result of its compatibility, the rutile and anatase TiO 2 surfaces can serve as substrates for growing different cell types [ 2 , 33 , 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…These applications depend on the following characteristics of the TiO 2 films: specific surface area, crystal and grain size, phase, concentration and dopant. TiO 2 films can be synthesized through different methods which include sol-gel, hydrothermal, spray pyrolysis, and physical vapor deposition (PVD) [ 1 , 2 , 3 , 4 , 5 , 6 ]. In health sciences, TiO 2 is used as a matrix to produce biosensors because of its high conductivity, chemical stability, and good biocompatibility [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity Evaluation of Anatase and Rutile TiO2 Thin Films on CHO-K1 Cells in Vitro

et al. 2016

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Cytotoxicity of titanium dioxide (TiO2) thin films on Chinese hamster ovary (CHO-K1) cells was evaluated after 24, 48 and 72 h of culture. The TiO2 thin films were deposited using direct current magnetron sputtering. These films were post-deposition annealed at different temperatures (300, 500 and 800 °C) toward the anatase to rutile phase transformation. The root-mean-square (RMS) surface roughness of TiO2 films went from 2.8 to 8.08 nm when the annealing temperature was increased from 300 to 800 °C. Field emission scanning electron microscopy (FESEM) results showed that the TiO2 films’ thickness values fell within the nanometer range (290–310 nm). Based on the results of the tetrazolium dye and trypan blue assays, we found that TiO2 thin films showed no cytotoxicity after the aforementioned culture times at which cell viability was greater than 98%. Independently of the annealing temperature of the TiO2 thin films, the number of CHO-K1 cells on the control substrate and on all TiO2 thin films was greater after 48 or 72 h than it was after 24 h; the highest cell survival rate was observed in TiO2 films annealed at 800 °C. These results indicate that TiO2 thin films do not affect mitochondrial function and proliferation of CHO-K1 cells, and back up the use of TiO2 thin films in biomedical science.

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“…TiO 2 films are an option for use in solar cells, photocatalysis, sensors, photoelectrolysis, biomedical devices, and biomaterials [ 20 , 21 , 22 , 23 , 24 , 25 ]. TiO 2 has three main polymorphic phases: rutile, anatase and brookite.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Surface Properties of TiO2 Thin Films Deposited by DC Magnetron Sputtering

et al. 2014

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We present the study of the biocompatibility and surface properties of titanium dioxide (TiO2) thin films deposited by direct current magnetron sputtering. These films are deposited on a quartz substrate at room temperature and annealed with different temperatures (100, 300, 500, 800 and 1100 °C). The biocompatibility of the TiO2 thin films is analyzed using primary cultures of dorsal root ganglion (DRG) of Wistar rats, whose neurons are incubated on the TiO2 thin films and on a control substrate during 18 to 24 h. These neurons are activated by electrical stimuli and its ionic currents and action potential activity recorded. Through X-ray diffraction (XRD), the surface of TiO2 thin films showed a good quality, homogeneity and roughness. The XRD results showed the anatase to rutile phase transition in TiO2 thin films at temperatures between 500 and 1100 °C. This phase had a grain size from 15 to 38 nm, which allowed a suitable structural and crystal phase stability of the TiO2 thin films for low and high temperature. The biocompatibility experiments of these films indicated that they were appropriated for culture of living neurons which displayed normal electrical behavior.

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Biocompatibility studies on TiO<inf>2</inf> coated Ti surface

Cited by 10 publications

References 14 publications

Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

Titanium surface bio-functionalization using osteogenic peptides: Surface chemistry, biocompatibility, corrosion and tribocorrosion aspects

Cytotoxicity Evaluation of Anatase and Rutile TiO2 Thin Films on CHO-K1 Cells in Vitro

Biocompatibility and Surface Properties of TiO2 Thin Films Deposited by DC Magnetron Sputtering

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