Biocompatibility Tests on Spray Coated Carbon Nanotube and PEDOT:PSS Thin Films

Bhatt, Vijay Deep; Melzer, K.; Abdellah, Alaa; Lugli, Paolo; Teymouri, Shokoufeh; Guttenberg, Zeno

doi:10.1109/tnano.2016.2535780

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…MD-7 is a commercialized biocompatible PSA. Further, many studies have reported that polymer–CNT composites can be used as biocompatible components. − Furthermore, the fabricated sensor is encapsulated by biocompatible and heat shrinkable polyester tubes, and therefore, the biocompatibility of our needle-integrated sensor is assured.…”

Section: Resultsmentioning

confidence: 99%

Ultrathin, Biocompatible, and Flexible Pressure Sensor with a Wide Pressure Range and Its Biomedical Application

Jeong

Park

Lee³

et al. 2020

ACS Sens.

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In this research, an ultrathin, biocompatible, and flexible pressure sensor with a wide pressure range has been developed and applied in biomedical applications. The pressure sensing mechanism is based on the variation of contact resistance between an electrode and a three-dimensional microstructured polyimide/carbon nanotube composite film. The sensor has a thickness of about 31.3 μm, a maximum sensitivity of 41.0 MPa–1, and a sensing range of 10–500 kPa. Moreover, in situ temperature measurement by an integrated resistive temperature detector enables data correction for varying temperature conditions. In order to show the advantages of the fabricated sensor, it is attached to the human body and integrated with the surface of a radiofrequency ablation (RFA) needle with small radius of curvature. In the experiments, the proposed pressure sensor measured subtle pressure levels (pulse pressure) and high pressure levels (fingertip pressure) without losing conformal contact with the skin. In addition, when the pressure-sensor-integrated RFA needle was inserted into a bovine liver, successful detection of steam popping phenomenon was observed.

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Section: Resultsmentioning

confidence: 99%

Ultrathin, Biocompatible, and Flexible Pressure Sensor with a Wide Pressure Range and Its Biomedical Application

Jeong

Park

Lee³

et al. 2020

ACS Sens.

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“…In particular, we investigated cell behaviour on two prototypical PEDOT: PSS layouts, i.e., PEDOT thin films deposited from a commercial water dispersion or by electrochemical polymerisation. Whereas electrodeposited PEDOT: PSS is known to be generally not cytotoxic ( Asplund et al, 2009 ; Asplund et al, 2010 ; Castagnola et al, 2015 ; Yazdimamaghani et al, 2015 ; Bhatt et al, 2016 ), that is not always the case for the water dispersions. Indeed, highly conductive formulations usually come with the presence of additives with questionable toxicity and often are available at very low pH values ( Stříteský et al, 2018 ; Kim et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

PEDOT: PSS promotes neurogenic commitment of neural crest-derived stem cells

et al. 2022

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Poly (3,4-ethylendioxythiophene) polystyrene sulphonate (PEDOT:PSS) is the workhorse of organic bioelectronics and is steadily gaining interest also in tissue engineering due to the opportunity to endow traditional biomaterials for scaffolds with conductive properties. Biomaterials capable of promoting neural stem cell differentiation by application of suitable electrical stimulation protocols are highly desirable in neural tissue engineering. In this study, we evaluated the adhesion, proliferation, maintenance of neural crest stemness markers and neurogenic commitment of neural crest-derived human dental pulp stem cells (hDPSCs) cultured on PEDOT:PSS nanostructured thin films deposited either by spin coating (SC-PEDOT) or by electropolymerization (ED-PEDOT). In addition, we evaluated the immunomodulatory properties of hDPSCs on PEDOT:PSS by investigating the expression and maintenance of the Fas ligand (FasL). We found that both SC-PEDOT and ED-PEDOT thin films supported hDPSCs adhesion and proliferation; however, the number of cells on the ED-PEDOT after 1 week of culture was significantly higher than that on SC-PEDOT. To be noted, both PEDOT:PSS films did not affect the stemness phenotype of hDPSCs, as indicated by the maintenance of the neural crest markers Nestin and SOX10. Interestingly, neurogenic induction was clearly promoted on ED-PEDOT, as indicated by the strong expression of MAP-2 and β—Tubulin-III as well as evident cytoskeletal reorganisation and appreciable morphology shift towards a neuronal-like shape. In addition, strong FasL expression was detected on both undifferentiated or undergoing neurogenic commitment hDPSCs, suggesting that ED-PEDOT supports the expression and maintenance of FasL under both expansion and differentiation conditions.

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