Biocompatible 3D printing resins for medical applications: A review of marketed intended use, biocompatibility certification, and post-processing guidance

Guttridge, Callum; Shannon, Alice; O’Sullivan, Aidan; O’Sullivan, Kevin J.; O’Sullivan, Leonard

doi:10.1016/j.stlm.2021.100044

Cited by 58 publications

(34 citation statements)

References 18 publications

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“…At the same time, it is highly desirable to re‐use the plant holders to limit the waste produced. We therefore aimed to produce our plant holders by 3D‐printing of autoclavable material, namely M2S‐HT90 [ 26 , 27 ]. The material has a heat deflection temperature of 90°C and is capable of meeting USP Class VI standards for biocompatibility.…”

Section: Resultsmentioning

confidence: 99%

3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants

Chuang

Enders

Offermann

et al. 2022

Engineering in Life Sciences

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The Australian tobacco plant Nicotiana benthamiana is becoming increasingly popular as a platform for protein production and metabolic engineering. In this system, gene expression is achieved transiently by infiltrating N. benthamiana plants with suspensions of Agrobacterium tumefaciens carrying vectors with the target genes. To infiltrate larger numbers of plants, vacuum infiltration is the most efficient approach known, which is already used on industrial scale. Current laboratory-scale solutions for vacuum infiltration, however, either require expensive custom-tailored equipment or produce large amounts of biologically contaminated waste. To overcome these problems and lower the burden to establish vacuum infiltration in new laboratories, we present here 3D-printed plant holders for vacuum infiltration. We demonstrate that our plant holders are simple to use and enable a throughput of around 40 plants per hour. In addition, our 3D-printed plant holders are made from autoclavable material, which tolerate at least 12 autoclave cycles, helping to limit the production of contaminated waste and thus contributing to increased sustainability in research. In conclusion, our plant holders provide a simple, robust, safe and transparent platform for laboratory-scale vacuum infiltration that can be readily adopted by new laboratories interested in protein and metabolite production in Nicotiana benthamiana. Practical applicationTransient expression in Nicotiana benthamiana provides a popular and rapid system for producing proteins in a plant host. To infiltrate larger numbers of plants (typically >20), vacuum infiltration is the method of choice. However, no system has been described so far which is robust to use and can be used without expensive and complex equipment. Our autoclavable 3D-printed plant Abbreviations: CFU, colony forming units; GFP, green fluorescent protein; N. benthamiana, Nicotiana benthamiana; PLA, polylactic acid.

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Section: Resultsmentioning

confidence: 99%

3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants

Chuang

Enders

Offermann

et al. 2022

Engineering in Life Sciences

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“…In-house knowledge allows choosing the most appropriate technology, avoiding market dependency and defining the optimal processes [ 54 , 55 ]. Buying mature, validated and stable manufacturing technologies is mandatory [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Implementation of an In-House 3D Manufacturing Unit in a Public Hospital’s Radiology Department

et al. 2022

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Objective: Three-dimensional printing has become a leading manufacturing technique in healthcare in recent years. Doubts in published studies regarding the methodological rigor and cost-effectiveness and stricter regulations have stopped the transfer of this technology in many healthcare organizations. The aim of this study was the evaluation and implementation of a 3D printing technology service in a radiology department. Methods: This work describes a methodology to implement a 3D printing service in a radiology department of a Spanish public hospital, considering leadership, training, workflow, clinical integration, quality processes and usability. Results: The results correspond to a 6-year period, during which we performed up to 352 cases, requested by 85 different clinicians. The training, quality control and processes required for the scaled implementation of an in-house 3D printing service are also reported. Conclusions: Despite the maturity of the technology and its impact on the clinic, it is necessary to establish new workflows to correctly implement them into the strategy of the health organization, adjusting it to the needs of clinicians and to their specific resources. Significance: This work allows hospitals to bridge the gap between research and 3D printing, setting up its transfer to clinical practice and using implementation methodology for decision support.

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“…The chips were produced using stereolithography (SLA) 3D printing in biocompatible resin (BioMed Clear, FormLabsTM, France) with a printing resolution XYZ of 50 mm. According to the manufacturer's technical specications, the Biomed Clear was developed in compliance with international standards ISO 10993-1:2018, ISO 7405:2009/(R) 2015, and ISO 18562-1:2017, 16 and it has already been used in biomedical applications by other groups. 17,18 The used printer model was the Mars 2 Pro resin 3D printer with a 2K mono LCD (ELEGOO, China).…”

Section: Elaboration and Preparation Of Microuidic Chipsmentioning

confidence: 99%

A miniaturized genotoxicity evaluation system for fast biomaterial-related risk assessment

et al. 2023

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Biocompatible 3D printing resins for medical applications: A review of marketed intended use, biocompatibility certification, and post-processing guidance

Cited by 58 publications

References 18 publications

3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants

3D‐printed autoclavable plant holders to facilitate large‐scale protein production in plants

Implementation of an In-House 3D Manufacturing Unit in a Public Hospital’s Radiology Department

A miniaturized genotoxicity evaluation system for fast biomaterial-related risk assessment

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