Biocompatible and Biodegradable Neuromorphic Device Based on Hyaluronic Acid for Implantable Bioelectronics

Abstract

Neurodegenerative disorders are challenging issues for initial diagnosis and cure. False signals from neurons that make up the brain must be corrected. To treat neurodegenerative diseases, neuromorphic devices are inserted into the body and connected to nerves. However, there are major concerns regarding implanting these devices into living bodies, that is, toxicity caused by the materials and the need for an additional operation to remove the device after treatment. In this research, a neuromorphic device is fabricated based on hyaluronic acid (HA), which is biocompatible and biodegradable, that meets the requirements for implantable bioelectronics. The fabricated device have a paired-pulse facilitation index of ≈121.00% and short term-tolong term memory transition behavior that resembled human learning-experience behavior. It is confirmed that the synaptic behavior mechanism of the device is due to an Mg oxide layer formed at the Mg/HA interface. Biodegradability and cell cytotoxicity tests confirmed the suitability of HA-based neuromorphic devices as implantable bioelectronics. Based on the results, it is believed that such implantable devices will lead to better healthcare.

Study of Resistive Switching and Biodegradability in Ultralow Power Memory Device Based on All‐Inorganic Ag/AgBi2I7/ITO Structure

“…[53,54] In order to expand the application of the device in the biological field, the prepared device was put into a PBS solution similar to body fluid (PH = 7.4) to verify the biodegradability. [55] Figure 6 shows the dissolution process of the device in the PBS solution. The color of the film immediately changed from reddish brown to bright yellow when the Ag/AgBi 2 I 7 /ITO device was just immersed in PBS (PH = 7.4) solution, then the Ag electrode began to dissolve after 15 minutes.…”

Advances in Emerging Photonic Memristive and Memristive‐Like Devices

“…The biocompatibility of the cyclo-YY paves a new way to construct the artificial cogni-retina. In fact, biocompatible materials can achieve the interface between the electronic devices and the biological environment, while it can meet the new requirements of the development and broaden the corresponding biotechnology and semiconductor applications, such as implant chips, [242,243] artificial neurons [244,245] and electronic skin. [246][247][248] Ferroelectric materials have promising potential in traditional non-volatile memory as a result of the characteristics of ferroelectric phase transition under an electric field.…”

Recent Progress in Bio‐Integrated Intelligent Sensing System

“…Following, we choose several example materials to demonstrate their main features that suit biointegrated applications. [8,15] In the last a few decades-given the technological advances and the increasing thirst to find green materials to interface with different biological environments in the human body-various flexible natural materials have been used in the bio-integrated sensing fields. As shown in Figure 2 and Table 1, those materials have shown robust advances in several aspects, such as mechanical flexibility, biocompatibility, and nontoxic biodegradation, which are difficult to simultaneously find in other conventional synthetic materials.…”

“…Following, we choose several example materials to demonstrate their main features that suit bio‐integrated applications. [ 8,15 ]…”

“…[1][2][3][4][5][6][7] Based on the continuous exploration in the fields of personalized healthcare, human enhancement, virtual/ augmented/mixed reality, etc., the bio-integrated intelligent sensing system (BISS) is the centerpiece that links the human with supporting intelligent devices. [8][9][10][11][12][13][14][15][16][17] The purpose of BISS is to achieve human-centered sensing, reverse stimulation, and data collection; such information is subsequently transmitted to the backend equipment, so as to realize features extraction, data analysis, and following applications. To separate the concept of BISS from conventional human-machine interface (HMI), such as keyboard, touch screen, and voice controller, bio-integrity and intelligent recognition are the two key differences (Figure 1a).…”