Biocompatible and mechanically robust nanocomposite hydrogels for potential applications in tissue engineering

Kouser, Rabia; Vashist, Arti; Zafaryab, Md.; Rizvi, Moshahid Alam; Ahmad, Sharif

doi:10.1016/j.msec.2017.11.018

Cited by 56 publications

(29 citation statements)

References 70 publications

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“…The corresponding composites present better mechanical strength, water absorption capacity, biocompatibility, biodegradability, and so on. Moreover, extensive research studies have been done in using these nanofillers in tissue engineering, replacing, or restoring defective tissues . In order to improve their antibacterial properties, modifications with most effective antimicrobial agents such as silver nanoparticles have also been proposed .…”

Section: Nanofillersmentioning

confidence: 99%

“…Moreover, extensive research studies have been done in using these nanofillers in tissue engineering, replacing, or restoring defective tissues. [254] In order to improve their antibacterial properties, modifications with most effective antimicrobial agents such as silver nanoparticles have also been proposed. [255] Xylan chains have also been added to CS nanocomposites due to their antibacterial and antioxidant properties.…”

Section: Chitinmentioning

confidence: 99%

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An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

2019

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Polymeric nanocomposites are the materials incorporating nanosized inclusions into the polymer matrixes. The result of the addition of nanoparticles/fibers is a drastic improvement in properties that may include mechanical, electrical, thermal conductivity, or even the acoustical properties. Polymer nanocomposites have spawned huge interest for the development of high‐performance products such as lightweight sensors, thin‐film capacitors, batteries, flame retardant products, biodegradable and biocompatible materials, and so on. The field of polymer nanocomposites has been at the forefront of research in the polymer community for the past few decades and an extremely large number of scientific papers have been published. Nevertheless, application‐oriented guidelines for selecting the ecofriendly nanocomposites for advanced industrial applications are missing in the state of the art. This review article summarizes the current state‐of‐the‐art polymeric nanocomposites, highlighting prominent nanofillers categorized based on their applications, origins, dimensional characteristics, and so on. Each filler type contains a short description of its main feature together with the most relevant and potential applications. To address the global concern about nondegradable wastes, novel green alternatives of each nanofiller type are discussed. Special attention is also given to the biocompatibility properties of the composites. This study provides a state‐of‐the‐art road map to select multifunctional polymeric nanocomposites from huge varieties for advanced industrial applications.

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Section: Nanofillersmentioning

confidence: 99%

Section: Chitinmentioning

confidence: 99%

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

2019

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“…The additional absorption peaks at 2111 and 2100 cm –1 (C≡N group) were pragmatic in NaCHAP-3, CHAP-3, and CHAP-1, indicating superficial AN grafting on CHAP and NaCHAP nanocomposite hydrogel films. 27 …”

Section: Resultsmentioning

confidence: 99%

“…The CHAP and NaCHAP nanocomposite hydrogel films were primed via a simple solution blending technique. 27 CMC (2%) and HEC aqueous solutions (2%) (20 mL each) were charged in a 200 mL beaker, followed by the addition of 5 mL of acrylonitrile (AN), different concentrations of 1% linseed oil polyol ( Table S1 ) as cross-linking agent, and different amounts (3 and 6 mg) of NaMMT dispersed in CHAP aqueous solution under sonication for 1 h to confirm the complete dispersion of NaMMT, followed by 72 h stirring by a magnetic stirrer. The prepared nanocomposite hydrogels were discharged into a Petri dish kept at room temperature (25 °C) until the films were obtained.…”

Section: Experimental Sectionmentioning

confidence: 99%

Na-Montmorillonite-Dispersed Sustainable Polymer Nanocomposite Hydrogel Films for Anticancer Drug Delivery

et al. 2018

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Nanocomposite hydrogels have found a wide scope in regenerative medicine, tissue engineering, and smart drug delivery applications. The present study reports the formulations of biocompatible nanocomposite hydrogel films using carboxymethyl cellulose-hydroxyethyl cellulose-acrylonitrile-linseed oil polyol (CHAP) plain hydrogel and Na-montmorillonite (NaMMT) dispersed CHAP nanocomposite hydrogel films (NaCHAP) using solution blending technique. The structural, morphological, and mechanical properties of resultant nanocomposite hydrogel films were further investigated to analyze the effects of polyol and NaMMT on the characteristic properties. The synergistic effect of polyol and nanofillers on the mechanical strength and sustained drug-release behavior of the resultant hydrogel films was studied, which revealed that the increased cross-link density of hydrogels enhanced the elastic modulus (up to 99%) and improved the drug retention time (up to 72 h at both pHs 7.4 and 4.0). The release rate of cisplatin in nanocomposite hydrogel films was found to be higher in CHAP-1 (83 and 69%) and CHAP-3 (79 and 64%) than NaCHAP-3 (77 and 57%) and NaCHAP-4 (73 and 54%) at both pHs 4.0 and 7.4, respectively. These data confirmed that the release rate of cisplatin in nanocomposite hydrogel films was pH-responsive and increased with decrease of pH. All nanocomposite hydrogel films have exhibited excellent pH sensitivity under buffer solution of various pHs (1.0, 4.0, 7.4, and 9.0). The in vitro biocompatibility and cytotoxicity tests of these films were also conducted using 3-(4,5-dimethylthiazole-2-yl-2,5-diphenyl tetrazolium bromide) assay of human embryonic kidney (HEK-293) and human breast cancer (MCF-7) cell lines up to 48 h, which shows their biocompatible nature. However, cisplatin-loaded nanocomposite hydrogel films effectively inhibited the growth of human breast MCF-7 cancer cells. These studies suggested that the proposed nanocomposite hydrogel films have shown promising application in therapeutics, especially for anticancer-targeted drug delivery.

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“…Carbon nanotubes (CNTs) [1] are one of the great carbonaceous nanomaterial displaying interesting properties such as high aspect ratio (~ 1000), remarkable tensile strength, chemical stability, huge surface area, notable electrical and thermal properties. Such properties are linked to their functionalities, structure and morphology [2] which make CNTs potential candidates for different applications such as in tissue engineering [3], solar and fuel cells, hydrogen storage and generation [4], supercapacitors, lithium ion batteries, field emission sources and electrochemical sensors [5], to cite a few. CNTs are usually categorized into single-wall carbon nanotubes (SWCNTs) and multi-wall carbon nanotubes (MWCNTs) [6].…”

Section: Introductionmentioning

confidence: 99%

Differently substituted aniline functionalized MWCNTs to anchor oxides of Bi and Ni nanoparticles

et al. 2019

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We have studied the consequence of different functionalization types onto the decoration of multi-wall carbon nanotubes (MWCNTs) surface by nanoparticles of bismuth and nickel oxides. Three organic molecules were considered for the functionalization: 5-amino-1,2,3-benzenetricarboxylic acid, 4-aminobenzylphosphonic acid and sulfanilic acid. Nanotubes modification with in situ created diazonium salts followed by their impregnation with suitable salts [ammonium bismuth citrate and nickel (II) nitrate hexahydrate] utilizing infrared (IR) irradiation was found the crucial stage in the homogeneous impregnation of functionalized CNTs. Furthermore, calcination of these samples in argon environment gave rise to controlled decorated MWCNTs. The currently used technique is simple as well as effective. The synthesized materials were characterized by XPS, PXRD, FESEM, EDX, HRTEM and Raman spectroscopy. Bismuth oxide decorations were successfully performed using 5-amino-1,2,3-benzenetricarboxylic acid (particle size ranges from 1 to 10 nm with mean diameter ~ 2.4 nm) and 4-aminobenzylphosphonic acid (particle size ranges from 1 to 6 nm with mean diameter ~ 1.9 nm) functionalized MWCNTs. However, only 4-aminobenzylphosphonic acid functionalized MWCNTs showed strong affinity towards oxides of nickel nanoparticles (mainly in hydroxide form, particles size ranging from 1 to 6 nm with mean diameter ~ 2.3 nm). Thus, various functions arranged in the order of their increasing anchoring capacities are as follows: sulfonic < carboxylic < phosphonic. The method is valid for large-scale preparations. These advanced nanocomposites are potential candidates for various applications in nanotechnology.

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Biocompatible and mechanically robust nanocomposite hydrogels for potential applications in tissue engineering

Cited by 56 publications

References 70 publications

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

An application‐oriented roadmap to select polymeric nanocomposites for advanced applications: A review

Na-Montmorillonite-Dispersed Sustainable Polymer Nanocomposite Hydrogel Films for Anticancer Drug Delivery

Differently substituted aniline functionalized MWCNTs to anchor oxides of Bi and Ni nanoparticles

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