Biocompatible and pH-sensitive MnO-loaded carbonaceous nanospheres (MnO@CNSs): A theranostic agent for magnetic resonance imaging-guided photothermal therapy

Xiang, Ying; Li, Nianlu; Guo, Lijuan; Wang, Hong; Sun, Haofeng; Li, Ruohan; Ma, Longlong; Qi, Yafei; Zhan, Jinhua; Yu, Dexin

doi:10.1016/j.carbon.2018.04.058

Cited by 28 publications

(25 citation statements)

References 67 publications

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“…The surface temperature of lymph nodes increased rapidly from 25.28°C to 55.64°C within 5 mins under laser irradiation, while the surrounding typical tissues did not increase significantly 53. Similarly, Xiang et al encapsulated MnO with carbon nanospheres to obtain MnO@CNSs (CNSs) with MR imaging and photothermal therapy performance 14. In order to enhance the phototherapy effect, Zhou and colleagues synthesized a mitochondria-targeted multifunctional nano-photosensitizer (IR808@MnO NP), utilizing IR808 as a tumor-targeting ligand.…”

Section: Mno-based Nanoparticles In Tumor Diagnosis and Therapymentioning

confidence: 99%

“…Gd-based T1 CAs in the form of ionic complexes have been extensively used in clinical practice 11. However, usual small size complex-based agents tend to suffer from short blood circulation time and distinct toxicity in vivo, which has the potential to cause nephrogenic systemic fibrosis and cerebral deposition 12–14. Researchers have turned to superparamagnetic nanoparticles, especially Fe 3 O 4 NPs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

Cai¹,

Zhu²,

Zeng³

et al. 2019

IJN

188

118

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Contrast agents (CAs) play a crucial role in high-quality magnetic resonance imaging (MRI) applications. At present, as a result of the Gd-based CAs which are associated with renal fibrosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide nanoparticles, Mn-based CAs which have a good biocompatibility and bright images are considered ideal for MRI. In addition, manganese oxide nanoparticles (MONs, such as MnO, MnO2, Mn3O4, and MnOx) have attracted attention as T1-weighted magnetic resonance CAs due to the short circulation time of Mn(II) ion chelate and the size-controlled circulation time of colloidal nanoparticles. In this review, recent advances in the use of MONs as MRI contrast agents for tumor detection and diagnosis are reported, as are the advances in in vivo toxicity, distribution and tumor microenvironment-responsive enhanced tumor chemotherapy and radiotherapy as well as photothermal and photodynamic therapies.

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Section: Mno-based Nanoparticles In Tumor Diagnosis and Therapymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

Cai¹,

Zhu²,

Zeng³

et al. 2019

IJN

188

118

View full text Add to dashboard Cite

show abstract

“…Various T1or T2-MRI CAS based on NPS gadolinium, manganese, and iron oxide were developed to increase the contrast sensitivity of images. However, conventional drugs based on small-sized complexes usually suffer from short blood circulation times and severe in vivo toxicity, which can lead to nephrogenic systemic fibrosis and cerebral deposition (Xiang et al, 2018).…”

Section: Selective and Complex Effects On The Tumor: Recent Findings And Directions Of Developmentmentioning

confidence: 99%

Modern Nanomaterials and Nanotechnology in Diagnosis and Treatment of Malignant Tumors of Gastrointestinal Tract

2019

European Journal of Molecular Biotechnology

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This review aims to systematize current achievements in the use of nanotechnology for the detection, diagnosis, treatment and prognosis of gastrointestinal (GI) malignant tumors. Information about the use of nanovesicles isolated from the body (exosomes) and synthesized (liposomes) for targeted delivery of drugs and imaging agents to cancer cells for this purpose is presented. A separate section of the review deals with revealing the laws of transport and interaction of nanoparticles with tumor cells to diagnose and treat GI malignant tumors. Here we present modern research to determine the effectiveness of micelles, liposomes, solid lipid nanoparticles, mesoporous silica nanoparticles and particles containing perfluorocarbon. The problems and achievements in the use of nanoparticles for targeted delivery of chemotherapy drugs to cancer cells using ultrasound are considered. The authors conclude the review with a list of the most promising areas of development in this field of molecular medicine and biotechnology, including combinations of direct cytotoxic action, immunomodulation, impact on tumor vessels (1), and combination of diagnostic component with facilitating the detection of tumor cells well-known as teranostics.

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“…Upon near-infrared (NIR) irradiation, photothermal reagents can rapidly convert light into heat to kill cancer cells through hyperthermia. Carbon-based materials [6][7][8][9] exhibit great potential as photothermal agents because of their unique optical features, good biocompatibility, and low biotoxicity. However, the therapeutic effect of carbon-based materials is hindered due to the low photothermal conversion efficiency.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy

et al. 2020

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Inspired by the limitations of nanoparticles in cancer treatment caused by their low therapeutic effects and biotoxicity, biocompatible and photothermal enhanced copper oxide-decorated carbon nanospheres (CuO@CNSs) with doxorubicin hydrochloride (DOX) loading were constructed. CNSs as photothermal agents were synthesized by a hydrothermal reaction. CuO was adsorbed on the surface of CNSs, which improved the photothermal conversion efficiency due to the electron transitions between C-2p and Cu-3d. In addition, CuO would release Cu 2+ ions in the tumor microenvironment, which could produce hydroxyl radical (•OH) to induce cancer cells apoptosis via Haber-Weiss and Fenton-like reactions. DOX as a chemotherapeutic agent was located on the surface of CuO@CNSs by electrostatic adsorption and released quickly in the tumor microenvironment to kill cancer cells. The CuO@CNSs-DOX nanoplatforms realized the combination therapy of photothermal therapy (PTT), chemodynamic therapy (CDT), and chemotherapy (CT), which have strong potential for cancer treatment.

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Biocompatible and pH-sensitive MnO-loaded carbonaceous nanospheres (MnO@CNSs): A theranostic agent for magnetic resonance imaging-guided photothermal therapy

Cited by 28 publications

References 67 publications

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

<p>Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy</p>

Modern Nanomaterials and Nanotechnology in Diagnosis and Treatment of Malignant Tumors of Gastrointestinal Tract

Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy

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