Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine

Yang, Hong; Lin, Zening; Yang, Yun; Jiang, Tao; Shang, Jianzhong; Luo, Zirong

doi:10.3390/ijms23094578

Cited by 47 publications

(20 citation statements)

References 159 publications

(138 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to avoiding damage to the human body, biocompatible hydrogels can even promote tissue regeneration. When the hydrogel material is applied to the wound, the 3D porous structure inside the hydrogel can carry bioactive components (such as biomolecules, proteins, and growth factors) to control and promote tissue regeneration and development [ 136 ].…”

Section: Design Strategies Of Composite Hydrogelsmentioning

confidence: 99%

Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

et al. 2023

View full text Add to dashboard Cite

Growing health awareness triggers the public’s concern about health problems. People want a timely and comprehensive picture of their condition without frequent trips to the hospital for costly and cumbersome general check-ups. The wearable technique provides a continuous measurement method for health monitoring by tracking a person’s physiological data and analyzing it locally or remotely. During the health monitoring process, different kinds of sensors convert physiological signals into electrical or optical signals that can be recorded and transmitted, consequently playing a crucial role in wearable techniques. Wearable application scenarios usually require sensors to possess excellent flexibility and stretchability. Thus, designing flexible and stretchable sensors with reliable performance is the key to wearable technology. Smart composite hydrogels, which have tunable electrical properties, mechanical properties, biocompatibility, and multi-stimulus sensitivity, are one of the best sensitive materials for wearable health monitoring. This review summarizes the common synthetic and performance optimization strategies of smart composite hydrogels and focuses on the current application of smart composite hydrogels in the field of wearable health monitoring.

show abstract

Section: Design Strategies Of Composite Hydrogelsmentioning

confidence: 99%

Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Conductive hydrogels (CHs) bear resemblances to natural soft tissues and extracellular matrices (ECMs), , manifesting outstanding ductility and resilience. In addition to these characteristics, CHs possess highly desirable attributes such as biocompatibility, conductivity, and self-repair capabilities, rendering them particularly advantageous for applications in wearable strain sensors, notably in health monitoring and medical diagnosis, among other fields. − The preparation of CHs typically involves employing the Schiff base reaction, , metal coordination, or multiple hydrogen bonds. , Furthermore, to enhance their conductive capacity, additives like Mexene, CNTs, rGOs, and AgNPs can be incorporated into the CHs. However, the fabrication of these multifunctional CHs often requires multiple synthesis steps and the addition of high-value fillers, leading to challenges in obtaining them with ease.…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of a Self-Adhesive Conductive Hydrogel with Long-Term Usability

Bai,

Yan,

Wang

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Although conductive hydrogels (CHs) have been investigated as the wearable sensor in recent years, how to prepare the multifunctional CHs with long-term usability is still a big challenge. In this paper, we successfully prepared a kind of conductive and self-adhesive hydrogel with a simple method, and its excellent ductility makes it possible as a flexible strain sensor for intelligent monitoring. The CHs are constructed by poly(vinyl alcohol) (PVA), polydopamine (PDA), and phytic acid (PA) through the freeze–thaw cycle method. The introduction of PA enhanced the intermolecular force with PVA and provided much H+ for augmented conductivity, while the catechol group on PDA endows the hydrogel with self-adhesion ability. The PVA/PA/PDA hydrogel can directly contact with the skin and adhere to it stably, which makes the hydrogel potentially a wearable strain sensor. The PVA/PA/PDA hydrogel can monitor human motion signals (including fingers, elbows, knees, etc.) in real-time and can accurately monitor tiny electrical signals for smile and handwriting recognition. Notably, the composite CHs can be used in a normal environment even after 4 months. Because of its excellent ductility, self-adhesiveness, and conductivity, the PVA/PA/PDA hydrogel provides a new idea for wearable bioelectronic sensors.

show abstract

“…Studies have revealed that CH dressings possess similar conductivity and flexibility to skin, supporting wound repair and tissue regeneration. 13,14 Conductive hydrogels allow for the creation of a conductive pathway that guides cell adhesion and migration, promoting skin tissue regeneration. 9,15 CHs are commonly prepared by introducing conductive materials such as conductive polymers, graphene, or metal nanoparticles into the crosslinked hydrogel matrix.…”

Section: Introductionmentioning

confidence: 99%

“…Considering that the conductivity of skin is about 10 –4 mS/cm and is sensitive to electrical signals, conductive hydrogels (CHs) have received attention due to their unique mechanical properties and conductivity. Studies have revealed that CH dressings possess similar conductivity and flexibility to skin, supporting wound repair and tissue regeneration. , Conductive hydrogels allow for the creation of a conductive pathway that guides cell adhesion and migration, promoting skin tissue regeneration. , CHs are commonly prepared by introducing conductive materials such as conductive polymers, graphene, or metal nanoparticles into the crosslinked hydrogel matrix . Poly(3,4-ethylenedioxythiophene) (PEDOT), polyaniline (PANI), and polypyrrole (PPy) have been used to prepare CHs owing to their conductive properties. − Moreover, the conductive polymers demonstrated antioxidant activity, which could support wound healing, based upon their conjugated backbone that can donate electrons for scavenging ROS. , For example, Zhu et al developed a single-electrode triboelectric nanogenerator-based e-skin patch to promote wound healing and sense motion using a polypyrrole/Pluronic F127 hydrogel as electrolytes.…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired PEDOT-Incorporated Gelatin-Based Conductive Hydrogel with Flexibility and Electroactivity to Accelerate Wound Healing In Vitro

Wan

Dong

et al. 2023

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Chronic wounds are associated with a metabolically imbalanced physiological microenvironment. However, conventional wound dressings are inadequate for treating chronic wounds due to their weak bioactivity. Electroactive wound dressings are essential for modulating a myriad of biological processes, particularly antioxidant activity and cell migration. Herein, we designed a conductive hydrogel with flexible, biodegradable, and electroactive properties using a mussel-inspired method. This conductive hydrogel was prepared by inducing poly(3,4-ethylenedioxythiophene) (PEDOT) in situ polymerization in the Hofmeister effect-assisted polydopamine-functionalized gelatin hydrogel (Gel-PDA/PEDOT). The hydrogel demonstrated robust mechanical properties with compressive and tensile strengths of 3.8 and 0.13 MPa, respectively, and a conductivity of 68.7 S/m. The addition of PDA and PEDOT to the Gel hydrogel endowed the hydrogel with exceptional antioxidant properties to maintain an intracellular redox balance. Additionally, the Gel-PDA/PEDOT hydrogel, which had favorable biocompatibility, significantly increased the migration and proliferation of fibroblasts due to its electroactive properties. A cell migration experiment was performed to assess whether the flexible and electroactive Gel-PDA/PEDOT hydrogel may be a promising wound dressing in skin wound regeneration. These findings provide a strategy for fabricating a multifunctional hydrogel with potential application in bioelectronics and wound dressings.

show abstract

Biocompatible Conductive Hydrogels: Applications in the Field of Biomedicine

Cited by 47 publications

References 159 publications

Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

Engineering Smart Composite Hydrogels for Wearable Disease Monitoring

Facile Preparation of a Self-Adhesive Conductive Hydrogel with Long-Term Usability

Mussel-Inspired PEDOT-Incorporated Gelatin-Based Conductive Hydrogel with Flexibility and Electroactivity to Accelerate Wound Healing In Vitro

Contact Info

Product

Resources

About