Biocompatible Cup‐Shaped Nanocrystal with Ultrahigh Photothermal Efficiency as Tumor Therapeutic Agent

Gao, Fengli; Sun, Maozhong; Xu, Liguang; Liu, Liqiang; Kuang, Hua; Xu, Chuanlai

doi:10.1002/adfm.201700605

Cited by 64 publications

(45 citation statements)

References 60 publications

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“…[19] Nanomaterials have great potential for cancer diagnosis [20,21] and therapy. [22][23][24][25][26] As one of the most widely used nanomaterials, silver nanoparticles (Ag NPs) have been proved to be effective in tumor treatment. [27][28][29] We previously reported that Ag NPs-induced cytoprotective autophagy and inhibition of autophagy by chemical inhibitors or ATG5 siRNA enhanced the antitumor effect of Ag NPs.…”

Section: Introductionmentioning

confidence: 99%

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

Lin

Liu

et al. 2018

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Transcription factor EB (TFEB) is a master regulator of autophagy and lysosomal biogenesis. Here, silver nanoparticles (Ag NPs)-induced cytoprotective autophagy required TFEB is shown. Ag NPs-induced nucleus translocation of TFEB through a well-established mechanism involving dephosphorylation of TFEB at serine-142 and serine-211 but independent of both the mTORC1 and ERK1/2 pathways. TFEB nucleus translocation precedes autophagy induced by Ag NPs and leads to enhanced expression of autophagy-essential genes. Knocking down the expression of TFEB attenuates the autophagy induction is demonstrated, and in the meantime, enhanced cell killing in HeLa cells treats with Ag NPs, indicating that TFEB is the key mediator for Ag NPs-induced cytoprotective autophagy. The results pinpoint TFEB as a potential target for developing more effective Ag NPs-based cancer therapeutics.

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Section: Introductionmentioning

confidence: 99%

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

Lin

Liu

et al. 2018

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“…[4][5][6][7][8][9][10] Reduced graphene-based drug-delivery systems have attracted the most attention because of their unique physical, electrical and chemicalp roperties, andt hey have been widely used as biomedical treatments, particularly for use in photothermal therapy( PTT) and cell imaging. [11][12][13][14][15][16][17][18][19][20][21][22] PTT is one of the mostp rominentm ethods for the application of rGO-based nanodrug systems. [23] Compared with traditional chemotherapy,P TT takes advantages of direct heatingo ft he cancerc ellsa nd results in minimal damaget os urrounding tissue.…”

Section: Introductionmentioning

confidence: 99%

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Zhang

Meng

et al. 2018

Chemistry A European J

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The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO)-polymer self-assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO-polymer carriers were constructed by the alternating assembly of poly-l-lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO-polymer bilayers and concentration of the rGO-polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH-responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.

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“…In vivo photothermal therapy showed great tumor growth inhibition efficacy by one‐time irradiation of NIR laser after a single injection of these multidentate PEG‐modified AuNRs . Xu and co‐workers reported a multifunctional PEG‐modified Au nanocup, with unique photothermal conversion efficiency, which could efficiently eliminate tumor tissues both in vitro and in vivo . Furthermore, PEGylation on AuNPs could also be beneficial for photodynamic therapy (PDT).…”

Section: Applicationmentioning

confidence: 99%

Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications

Luo

et al. 2018

Macromol. Rapid Commun.

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Gold nanoparticles (AuNPs), with elegant thermal, optical, or chemical properties due to quantum size effects, may serve as unique species for therapeutic or diagnostic applications. It is worth mentioning that their small size also results in high surface activity, leading to significantly impaired stability, which greatly hinders their biomedical utilizations. To overcome this problem, various types of macromolecular materials are utilized to anchor AuNPs so as to achieve advanced synergistic effect by dispersing, protecting, and stabilizing the AuNPs in polymeric-Au hybrid self-assemblies. In this review, the most recent development of polymer-AuNP hybrid systems, including AuNPs@polymeric nanoparticles, AuNPs@polymeric micelle, AuNPs@polymeric film, and AuNPs@polymeric hydrogel are discussed with respect to their different synthetic strategies. These sophisticated materials with diverse functions, oriented toward biomedical applications, are further summarized into several active domains in the areas of drug delivery, gene delivery, photothermal therapy, antibacterials, bioimaging, etc. Finally, the possible approaches for future design of multifunctional polymer-AuNP hybrids by combining hybrid chemistry with biological interface science are proposed.

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Biocompatible Cup‐Shaped Nanocrystal with Ultrahigh Photothermal Efficiency as Tumor Therapeutic Agent

Cited by 64 publications

References 60 publications

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications

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Biocompatible Cup‐Shaped Nanocrystal with Ultrahigh Photothermal Efficiency as Tumor Therapeutic Agent

Cited by 64 publications

References 60 publications

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle‐Induced Cytoprotective Autophagy

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Recent Progress in Macromolecule‐Anchored Hybrid Gold Nanomaterials for Biomedical Applications

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The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy