Biocompatible, Hemocompatible and Antibacterial Acylated Dextran-g-polyisobutylene Graft Copolymers with Silver Nanoparticles

Zhao, Cong-Lei; Gao, Yu-Zhuang; Wu, Mengying; Zhang, Hangtian; Wu, Yixian

doi:10.1007/s10118-021-2621-0

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Silver nanoparticles (Ag NPs) are a highly commercialized antibacterial agent and have been widely used in the medical field . However, the common methods for preparing Ag NPs involve toxic chemical reducing agents, which hinders their application in the field of biomaterials.…”

Section: Resultsmentioning

confidence: 99%

“…Poly(tetrahydrofuran) (PTHF) is a hydrophobic aliphatic saturated polyether elastomer synthesized from THF cationic ring-opening polymerization, having biological inertness and biocompatibility, wet strength, flexibility, and hydrolytic stability. − A series of PTHF-grafted copolymers have been synthesized in our previous works. − …”

Section: Introductionmentioning

confidence: 99%

“…In addition, Ag NPs can cause cell membrane denaturation . Ag NPs can be prepared by chemical reduction, electrochemical reaction, irradiation-assisted chemical reaction, or pyrolysis. − It is a plain and economical way to synthesize Ag NPs in situ through the coinitiator (AgClO 4 ) used for the synthesis of PTHF + living polymers in our works. – …”

Section: Introductionmentioning

confidence: 99%

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Amphiphilic Graft Copolymer of Polylysine-g-polytetrahydrofuran and Its Biological Properties

Chen

Cui

Gao

et al. 2022

ACS Appl. Polym. Mater.

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The graft copolymer of poly-(N-ε-carbobenzyloxy-Llysine)-g-poly(tetrahydrofuran) (PZLL-g-PTHF) could be successfully synthesized via the nucleophilic substitution reaction of PTHF + living polymer chains with secondary amine side groups in the PZLL backbone. The amphiphilic graft copolymers of polylysine-g-poly(tetrahydrofuran) (PLL-g-PTHF) could be obtained by complete deprotection of the precursor of PZLL-g-PTHF. The obvious microphase separation was observed in both PLL-g-PTHF and PZLL-g-PTHF because of the incompatibility between the two kinds of segments. Their micromorphology is dependent on the chemical structure of backbones and the grafting number (G N ) of branches. PZLL-g-PTHF is a hydrophobic graft copolymer and the water contact angles (WCAs) of copolymer surfaces decreased from 103 to 91°with the increase of G N from 5 to 21. Interestingly, PLL-g-PTHF is an amphiphilic graft copolymer and their WCAs increased from 52 to 90°with the increase of G N from 5 to 21. Both PZLL-g-PTHF and PLL-g-PTHF copolymers show good biocompatibility and anti-protein adsorption. The resulting PZLL-g-PTHF copolymers carrying a small amount of Ag nanoparticles, in situ generated from coinitiator AgClO 4 for the synthesis of PTHF + living chains, exhibit high killing efficiency (>95%) for both Escherichia coli and Staphylococcus aureus. PLL-g-PTHF/Ag nanocomposites show extremely high killing efficiency (>99%) against both S. aureus and E. coli for binary contribution from Ag nanoparticles and PLL. The antifouling and antibacterial graft copolymers would potentially have biological and medical applications.

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Section: Resultsmentioning

confidence: 99%