Biocompatible nanostructured solid adhesives for biological soft tissues

Abstract

The present study indicates a new application of inorganic biomaterials (bioceramics) as a soft tissue adhesive. Organic adhesives such as fibrin glues or cyanoacrylate derivatives have been commonly used clinically. However, their limited biocompatibility and/or low adhesion strength are some drawbacks that impair their clinical application. In this study, we synthesized a novel solid adhesive with biocompatible and biodegradable HAp nanoparticles without the aid of organic molecules, and showed a rapid and strong adhesion of mouse soft tissues compared to conventional fibrin glues. Given the importance of wet adhesion in biomedicine and biotechnology applications, our results will help not only in developing an efficient approach to close incised soft tissues, but also in finding novel ways to integrate soft tissues with synthetic hydrogels (such as drug reservoirs).

A Microarray Screening Platform with an Experimental Conditions Gradient Generator for the High-Throughput Synthesis of Micro/Nanosized Calcium Phosphates

“…In order to validate the practicability of our platform, the morphologies of calcium phosphates were screened utilizing this platform due to their excellent biocompatibility with soft tissues, muscles, and skin [20][21][22], and due to the fact that their morphology and structure highly influence the properties and applications for micro/nano calcium phosphate (CaP) materials [23,24]. The synthesis of CaP was based on a simple wet chemical precipitation method [25] with minor modifications, as described in our previously published article [19].…”

Titanium as an Instant Adhesive for Biological Soft Tissue

“…The mechanical strength of the adhesive itself should be substantially larger than the target tissue, because the adhesive would otherwise break under a large stress. [ 18 ] The tensile strength of nontreated Ti used in this study (see Figure S4 in the Supporting Information) was much larger than the minimum strength of grade 1 CPTi (240 MPa) defined by an American Society for Testing and Materials (ASTM) Standard, [ 30 ] which would be due to the cold rolling process during its fabrication. The tensile strength of acid‐treated Ti tends to decrease as increasing the acid treatment time.…”

“…[ 10,14 ] More recently, researchers have developed unique biocompatible adhesives with higher adhesive strength by using polymers [ 1,14–16 ] and ceramics. [ 17,18 ] However, polymers have limitations of their mechanical strength and ceramics show a brittle property.…”

“…By removing the surface layer from the acid‐treated Ti, the adhesion strength decreased significantly (see Figure S6 in the Supporting Information), supporting the importance of the hydrophobic and nanostructured TiH 2 layer formed by the acid treatment. The ex vivo shear adhesion strength of the 20‐min‐treated Ti film (57 kPa) was significantly higher than that of commercially available fibrin glue (e.g., 18 kPa) measured under the same conditions, [ 18 ] and was comparable to gelatin‐resorcinol‐formaldehyde/glutaraldehyde glue (e.g., 48 kPa) at wet conditions. [ 1 ] Of note, a simple autoclaving at 121 °C, which usually causes denaturation of most organic polymer biomaterials, could be used to sterilize the Ti films with no effect on the adhesion properties (Figure S7 in the Supporting Information).…”

Bone Mineral Analogue Ceramic Block as an Instant Adhesive to Biological Soft Tissue

“…Some bone‐substitute materials, such as titanium (Ti) and hydroxyapatite with excellent osteoconductivity, also strongly adhere to soft tissues. [ 13,14 ] Although the adhesive properties of non‐bioresorbable bone‐substitute materials are sufficient to immobilize an implantable device, the clinical applicability of these materials is limited by their non‐bioresorbable property. In real applications, the device must be both attachable and detachable.…”