Biocompatible polymers for medical application

Lipatova, T.E.; Lipatov, Yu.S.

doi:10.1002/1521-3900(200003)152:1<139::aid-masy139>3.0.co;2-v

Cited by 12 publications

(8 citation statements)

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“…In comparison with other polysaccharides (chitin and cellulose), chitosan (CS) has many physicochemical (polycationic, reactive OH and NH 2 groups) and biological (biocompatibility, biodegradability, and low toxicity) properties 2, 3. Such inherent properties of CS make it a suitable polymer for use in a number of biomedical applications, including artificial skin, tissue regeneration, and drug delivery systems 4–6…”

Section: Introductionmentioning

confidence: 99%

Molecular modeling study on surface, thermal, mechanical and gas diffusion properties of chitosan

Prathab

Aminabhavi

2007

J Polym Sci B Polym Phys

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The motivation of this work is to provide reliable and accurate modeling studies of the physical (surface, thermal, mechanical and gas diffusion) properties of chitosan (CS) polymer. Our computational efforts have been devoted to make a comparison of the structural bulk properties of CS with similar type of polymers such as chitin and cellulose through cohesive energy density, solubility parameter, hydrogen bonding, and free volume distribution calculations. Atomistic modeling on CS polymer using molecular mechanics (MM) and molecular dynamics (MD) simulations has been carried out in three dimensionally periodic and effective two dimensionally periodic condensed phases. From the equilibrated structures, surface energies were computed. The equilibrium structure of the films shows an interior region of mass density close to the value in the bulk state. Various components of energetic interactions have been examined in detail to acquire a better insight into the interactions between bulk structure and the film surface. MD simulation (NPT ensemble) has also been used to obtain polymer specific volume as a function of temperature. It is demonstrated that these V-T curves can be used to locate the volumetric glass transition temperature (T g ) reliably. The mechanical properties of CS have been obtained using the strain deformation method. Diffusion coefficients of O 2 , N 2 , and CO 2 gas molecules at 300 K in CS have been estimated. The calculated properties of CS are comparable with the experimental values reported in the literature.

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Section: Introductionmentioning

confidence: 99%

Molecular modeling study on surface, thermal, mechanical and gas diffusion properties of chitosan

Prathab

Aminabhavi

2007

J Polym Sci B Polym Phys

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“…Chitosan, a natural biomaterial, has recently attracted much attention from scientists in different parts of the world. − It has been reexamined and found to be a useful resource as a functional material. , Because of the presence of amino groups, chitosan is soluble in aqueous acidic media and forms viscous solutions that can be used to produce gels in various forms, e.g., beads, membranes, coatings, fibers, and sponges. − The amino and hydroxyl groups of chitosan give rise to it being easily chemically modified. Chitosan, as a functional material, offers a special set of characteristics: biocompatibility, biodegradability, and anti-bacterial properties. , It is also biologically inert, safe for human use, and stable in the natural environment. ,, The above characteristics make chitosan suitable for use in a number of biomedical applications, including artificial skin, tissue regeneration, and drug delivery systems. ,− It is vital that in all of these applications the material must be demonstrably nontoxic. In other words, the polymer, its possible degradation products, any residual monomer, and all additives must be free of harmful effects.…”

Section: Introductionmentioning

confidence: 99%

“…5,9,10 The above characteristics make chitosan suitable for use in a number of biomedical applications, including artificial skin, tissue regeneration, and drug delivery systems. 2,[11][12][13] It is vital that in all of these applications the material must be demonstrably nontoxic. In other words, the polymer, its possible degradation products, any residual monomer, and all additives must be free of harmful effects.…”

Section: Introductionmentioning

confidence: 99%

Novel Chitosan-Based Films Cross-Linked by Genipin with Improved Physical Properties

2003

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Novel cross-linked chitosan-based films were prepared using the solution casting technique. A naturally occurring and nontoxic cross-linking agent, genipin, was used to form the chitosan and chitosan/poly(ethylene oxide) (PEO) blend networks, where two types of PEO were used, one with a molecular weight of 20 000 g/mol (HPEO) and the other of 600 g/mol (LPEO). Genipin is used in traditional Chinese medicine and extracted from gardenia fruit. Importantly, it overcomes the problem of physiological toxicity inherent in the use of some common synthetic chemicals as cross-linking agents. The mechanical properties and the stability in water of cross-linked and un-crosslinked chitosan and chitosan/PEO blend films were investigated. It was shown that, compared to the transparent yellow, un-cross-linked chitosan/PEO blend films, the genipin-cross-linked chitosan-based film, blue in color, was more elastic, was more stable, and had better mechanical properties. Genipin-cross-linking produced chitosan networks that were insoluble in acidic and alkaline solutions but were able to swell in these aqueous media. The swelling characteristics of the films exhibit sensitivity to the environmental pH and temperature. The surface properties of the films were also examined by contact angle measurements using water and mixtures of water/ethanol. The results showed that, with the one exception of cross-linked pure chitosan in 100% water, the cross-linked chitosan and chitosan/PEO blends were more hydrophobic than un-crosslinked ones.

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“…Chitosan as obtained by the deacetylation of chitin has a subunit of (1,4)-linked 2-amino-2-deoxyb- d -glucan . Compared to other polysaccharides, CS has several inherent advantages such as biocompatibility, biodegradability, and low toxicity, , which renders it to be useful in biomedical applications, including artificial skin, tissue regeneration, and drug delivery. − …”

Section: Surface Energy Of Blendsmentioning

confidence: 99%

Atomistic Simulations to Compute Surface Properties of Poly(N-vinyl-2-pyrrolidone) (PVP) and Blends of PVP/Chitosan

Prathab

Aminabhavi

2007

Langmuir

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Atomistic simulations were performed on poly(N-vinyl-2-pyrrolidone) (PVP) and its blends with chitosan (CS) in different ratios using molecular mechanics (MM) and molecular dynamics (MD) simulations in three-dimensionally periodic and effective two-dimensionally periodic condensed phases. Four independent microstructures were generated to analyze their surface properties. The calculated surface-energy values for PVP compared quite well with the experimental data reported in the literature. The density profile was analyzed, and the structure of the films showed an interior region of the bulk density. Various components of the energetic interactions (torsional, van der Waals, etc.) were examined to gain deeper insight into the nature of regular and anomalous interactions between the bulk and the surface films. Surface energies of PVP/CS blends were computed by MD simulations using the bulk pressure-volume-temperature (PVT) parameters. Bulk properties such as the cohesive energy density (CED) and solubility parameter (delta) were calculated using MM and MD simulations in the NVT ensemble under periodic boundary conditions. The Flory equation of state was used to compute the thermal expansion coefficient as well as PVT parameters. These surface-energy values agreed well with the surface-energy data calculated using the Zisman equation, which were also in accordance with the experimental observations. The results from this study suggest that computer simulations would provide valuable information on polymers and polymer-blend surfaces.

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Biocompatible polymers for medical application

Cited by 12 publications

References 0 publications

Molecular modeling study on surface, thermal, mechanical and gas diffusion properties of chitosan

Molecular modeling study on surface, thermal, mechanical and gas diffusion properties of chitosan

Novel Chitosan-Based Films Cross-Linked by Genipin with Improved Physical Properties

Atomistic Simulations to Compute Surface Properties of Poly(N-vinyl-2-pyrrolidone) (PVP) and Blends of PVP/Chitosan

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