Biocompatible Porous Tantalum Metal Plates in the Treatment of Tibial Fracture

Zhao, Dewei; Ma, Zhijie; Wang, Tienan; Liu, Bao-yi

doi:10.1111/os.12432

Cited by 20 publications

(17 citation statements)

References 14 publications

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“…4e): physicochemical studies, 33,37,40-42,44,45,47,48,51-54 biological research, 12,17,18,31,32,34,36,38,39,43,46,49 and clinical application. 35,50 The first group included three subgroups, namely basic physical properties, 40,44,48 material modification, 33,41,42,45,47,54 and processing parameter analysis. 37,[51][52][53] The second group contained two subgroups namely basic biological properties 12,17,32,36,46 and implant modification.…”

Section: Resultsmentioning

confidence: 99%

Additively Manufactured Tantalum Implants for Repairing Bone Defects: A Systematic Review

Lei

et al. 2021

Tissue Engineering Part B: Reviews

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Tantalum has unique advantages as a biomaterial for repairing bone defects due to its outstanding bioactivity, excellent corrosion resistance, and mechanical properties. Ideal implants for bone repair should be of good biocompatibility and bioactivity, as well as ability to simulate the microstructure and mechanical environment of human bone tissues. Additive manufacturing can facilitate freedom of design for the macrostructure/ microstructure of bone implants with controlled mechanical properties; thus, this method has great potential. Additively manufactured tantalum implants provide a novel alternative for bone repair and are gaining increasing attention. This systematic review aims to comprehensively summarize the subsistent evidence from physicochemical, cellular, animal, and clinical studies on additively manufactured tantalum implants in repairing bone defects, for the first time. This work may provide researchers an essential grasp on the advances of additively manufactured tantalum implants.

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Section: Resultsmentioning

confidence: 99%

Additively Manufactured Tantalum Implants for Repairing Bone Defects: A Systematic Review

Lei

et al. 2021

Tissue Engineering Part B: Reviews

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“…A printed porous Ta osteosynthesis plate has been used for the treatment of a 30-year old male patient with tibial nonunion [ 191 ]. The patient had undergone intramedullary nail fixation three times previously, but failed to attain healing even associated with the iliac crest autograft.…”

Section: New Development Of Porous Ta For Bone Tissue Engineeringmentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

2021

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta-based implants or prostheses is mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta-based implants or prostheses have shown their clinical value in the treatment of individual patients who need specially designed implants or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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“…A printed porous Ta osteosynthesis plate has been used for the treatment of 30-year old male patient with tibial nonunion [186]. The patient had undergone intramedullary nail fixation three times before, but failed to union even associated with iliac crest autograft.…”

Section: Immunochemistrymentioning

confidence: 99%

“…Owing to the biological and biomechanical advantages, this novel porous Ta plate (porosity of 80%, elastic modulus of 1.5-10GPa) reunited the tibial shaft fracture uneventfully 5-month post the fourth surgery, and the patient regained normal mobility (see Figure 3). Reproduced content is open access [186].…”

Section: Immunochemistrymentioning

confidence: 99%

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The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

show abstract

Biocompatible Porous Tantalum Metal Plates in the Treatment of Tibial Fracture

Cited by 20 publications

References 14 publications

Additively Manufactured Tantalum Implants for Repairing Bone Defects: A Systematic Review

Additively Manufactured Tantalum Implants for Repairing Bone Defects: A Systematic Review

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

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