Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers

Filippousi, Maria; Turner, Stuart; Leus, Karen; Sıafaka, Panoraia I.; Tseligka, Eirini D.; Vandichel, Matthias; Nanaki, Stavroula; Vizirianakis, Ioannis S.; Bikiaris, Dimitrios N.; Voort, Pascal Van Der; Tendeloo, Gustaaf Van

doi:10.1016/j.ijpharm.2016.05.048

Cited by 108 publications

(59 citation statements)

References 48 publications

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“…173 It is of interest to use MOFs as carriers for the delivery of chemotherapeutic drugs for the cancer therapy, such as 5-FU, DOX, CPT, platinum drugs and methotrexate (MTX). 165,166,[174][175][176][177][178] Thus, 5-FU-loaded MOFs exhibit excellent anticancer activity against human spinal cord tumor cells. 179 DOX-loaded nano-sized MOFs (UiO-68) were modied with folic acid (FA) as a targeting agent and were used to effectively treat hepatoma by intravenous injection.…”

Section: Metal-organic Frameworkmentioning

confidence: 98%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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Section: Metal-organic Frameworkmentioning

confidence: 98%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…Additionally, Tendeloo and co‐workers were able to fabricate poly(ε‐caprolactone) coated Zr‐based MOFs for anticancer drug carriers . In this work, poly(ε‐caprolactone)–tocopheryl poly(ethylene glycol)‐succinate (PCL–TPGS) copolymer was engineered on the surface of UiO‐66 and UiO‐67 MOFs due to its biocompatibility and non‐toxicity.…”

Section: Multifunctional Mofs For Cancer Theranosticsmentioning

confidence: 99%

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

2017

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Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

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“…To the best of our knowledge, this approach has not been used for the surface functionalisation of zirconium MOFs, possibly because their water stability is higher than for other MOF systems. Zr MOFs coated with poly(ξ-caprolactone) in the form of microparticles have recently been reported [103]. The authors investigated UiO-66 and UiO-67 microencapsulation with a copolymer of poly(ξ-caprolactone) and D-α-tocopherol polyethylene glycol 1000 succinate (PCL-TPGS), a derivate of vitamin E and PEG.…”

Section: Postsynthetic Noncovalent Modificationmentioning

confidence: 99%

“…Encapsulation of MOF nanoparticles in polymer microspheres can also control release. UiO-66 and UiO-67 were loaded with cisplatin (4.8% w/w and 1% w/w, respectively) and taxol (14% w/w and 10% w/w, respectively) before microencapsulation in modified poly(ξcaprolactone), and their release kinetics in PBS (pH 7.4) were investigated [103]. Burst release of cisplatin from uncoated UiO-66 and UiO-67 was observed (70% and 90% release, respectively, after 5 h of exposure) followed by slow release of the remainder, either as a consequence of the majority of the drug being bound to the surfaces of the MOFs rather than stored in their pores, or to carrier instability.…”

Section: Controlling Cargo Releasementioning

confidence: 99%

Application of zirconium MOFs in drug delivery and biomedicine

Lázaro

Forgan

2019

Coordination Chemistry Reviews

552

176

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Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

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Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers

Cited by 108 publications

References 48 publications

Recent advances in metallopolymer-based drug delivery systems

Recent advances in metallopolymer-based drug delivery systems

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

Application of zirconium MOFs in drug delivery and biomedicine

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