Biocompatible ι-carrageenan-γ-maghemite nanocomposite for biomedical applications – synthesis, characterization and in vitro anticancer efficacy

Raman, Maya; Devi, Viswambari; Doble, Mukesh

doi:10.1186/s12951-015-0079-3

Cited by 44 publications

(25 citation statements)

References 61 publications

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“…Carrageenan-based micro-and nano-scale delivery systems have been reported, often taking advantage of the sulfate content, which results in a negative surface charge that promotes an uptake of cationic target molecules or facilitates functionalization with positively charged components for complex drug carriers [43,45]. Examples of systems reported in the literature include pH-responsive hydrogels for intestinal drug delivery [46], hybrid calcium-biopolymer microparticles for DOX delivery [47,48] and k-carrageenan-coated γ-Fe 2 O 3 nanoparticles with chemotherapeutic potential [49]. While there has been research on the combination of magnetic particles with carrageenan for drug delivery [27], there are no reported works combining such systems with DOX.…”

Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

et al. 2020

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Doxorubicin is one of the most widely used anti-cancer drugs, but side effects and selectivity problems create a demand for alternative drug delivery systems. Herein we describe a hybrid magnetic nanomaterial as a pH-dependent doxorubicin release carrier. This nanocarrier comprises magnetic iron oxide cores with a diameter of 10 nm, enveloped in a hybrid material made of siliceous shells and ĸ-carrageenan. The hybrid shells possess high drug loading capacity and a favorable drug release profile, while the iron oxide cores allows easy manipulation via an external magnetic field. The pH responsiveness was assessed in phosphate buffers at pH levels equivalent to those of blood (pH 7.4) and tumor microenvironment (pH 4.2 and 5). The nanoparticles have a loading capacity of up to 12.3 wt.% and a release profile of 80% in 5 h at acidic pH versus 25% at blood pH. In vitro drug delivery tests on human breast cancer and non-cancer cellular cultures have shown that, compared to the free drug, the loaded nanocarriers have comparable antiproliferative effect but a less intense cytotoxic effect, especially in the non-cancer cell line. The results show a clear potential for these new hybrid nanomaterials as alternative drug carriers for doxorubicin.

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Section: Characterization Of the Magnetic Nanocarriersmentioning

confidence: 99%

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

et al. 2020

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“…According to data from literature, polysaccharides that contain sulfate residue demonstrate bacteriostatic properties against S. enteritidis [44]. The lack of inhibitory abilities of the films with magnetic nanoparticles against the growth of S. enteritidis may have resulted from the fact that furcellaran might have the ability to electrostatically entrap the maghemite nanoparticles in their sulfate groups [45]. According to Yamashita, Sugita-Konishi and Shimizu [44], the removal or blockage of sulfate residues eliminate the bacteriostatic effect of polysaccharides.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

“…The sulfate group in at C-4 and (1→4)-3,-anhydro-'α-D-galactopyranose caused the anionic nature of furcellaran [48]. The ζ-potential of furcellaran is −40 mV and ζ-potential γ-Fe 2 O 3 nanoparticles are 33 mV [45,49]. The occurrence of the positively charged γ-Fe 2 O 3 nanoparticles inclusion to the surface of anionic polysaccharides is known.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Nanocomposite Furcellaran Films—the Influence of Nanofillers on Functional Properties of Furcellaran Films and Effect on Linseed Oil Preservation

Jamróz

Kopel

Tkaczewska³

et al. 2019

Polymers

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Nanocomposite films that were based on furcellaran (FUR) and nanofillers (carbon quantum dots (CQDs), maghemite nanoparticles (MAN), and graphene oxide (GO)) were obtained by the casting method. The microstructure, as well as the structural, physical, mechanical, antimicrobial, and antioxidant properties of the films was investigated. The incorporation of MAN and GO remarkably increased the tensile strength of furcellaran films. However, the water content, solubility, and elongation at break were significantly reduced by the addition of the nanofillers. Moreover, furcellaran films containing the nanofillers exhibited potent free radical scavenging ability. FUR films with CQDs showed an inhibitory effect on the growth of Staphylococcus aureus and Escherichia coli. The nanocomposite films were used to cover transparent glass containers to study the potential UV-blocking properties in an oil oxidation test and compare with tinted glass. The samples were irradiated for 30 min. with UV-B and then analyzed for oxidation markers (peroxide value, free fatty acids, malondialdehyde content, and degradation of carotenoids). The test showed that covering the transparent glass with MAN films was as effective in inhibiting the oxidation as the use of tinted glass, while the GO and CQDs films did not inhibit oxidation. It can be concluded that the active nanocomposite films can be used as a desirable material for food packaging.

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“…Hydrogels composed of polysaccharides with magnetic properties have been shown promising materials for application in many sectors …”

Section: Introductionmentioning

confidence: 99%

“…Raman et al . prepared a nanocomposite material based on iota‐carrageenan and maghemite (γ‐Fe 2 O 3 ) for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a superparamagnetic nanocomposite hydrogel for adsorptive performance in the wastewater treatment

Maciel

Silva

Ferreira

2019

J of Applied Polymer Sci

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Magnetic nanocomposite hydrogels based on carrageenan (kappa:iota = 1:1) and maghemite (γ-Fe 2 O 3 ) are prepared. Scanning electron microscopyimages show that the γ-Fe 2 O 3 is dispersed on the surface of the hydrogels and transmission electron microscopy images show that maghemite particles are in nanometric size. The hydrogels present superparamagnetic behavior and respond to the stimulus of a magnet. The samples crosslinked with KCl are classified as superabsorbent materials (swelling degree >700%) and they show a higher saturation magnetization value than those crosslinked with CaCl 2 . Vibrating sample magnetometry curves show that the hydrogels do not present a hysteresis cycle and the remanent magnetization in all the samples is near zero. The performance of the hydrogels is evaluated for adsorption of heavy metals from aqueous solutions. The samples are immersed in aqueous solutions containing Cd(II) and Pb(II) ions. After 150 min of immersion, the hydrogels remove about 40% and 30% of each heavy metal contaminant, respectively.Raman et al. 8 prepared a nanocomposite material based on iotacarrageenan and maghemite (γ-Fe 2 O 3 ) for biomedical applications. According to the authors, the results indicated that iota-carrageenan Additional Supporting Information may be found in the online version of this article.

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Biocompatible ι-carrageenan-γ-maghemite nanocomposite for biomedical applications – synthesis, characterization and in vitro anticancer efficacy

Cited by 44 publications

References 61 publications

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

Magnetic Driven Nanocarriers for pH-Responsive Doxorubicin Release in Cancer Therapy

Nanocomposite Furcellaran Films—the Influence of Nanofillers on Functional Properties of Furcellaran Films and Effect on Linseed Oil Preservation

Preparation of a superparamagnetic nanocomposite hydrogel for adsorptive performance in the wastewater treatment

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